PMID- 25439749
OWN - NLM
STAT- MEDLINE
DCOM- 20160506
LR  - 20181202
IS  - 1532-2653 (Electronic)
IS  - 0967-5868 (Linking)
VI  - 22
IP  - 1
DP  - 2015 Jan
TI  - A novel treatment strategy for glioblastoma multiforme and glioma associated 
      seizures: increasing glutamate uptake with PPARgamma agonists.
PG  - 21-8
LID - S0967-5868(14)00556-6 [pii]
LID - 10.1016/j.jocn.2014.09.001 [doi]
AB  - The established role of glutamate in the pathogenesis of glioma-associated 
      seizures (GAS) led us to investigate a novel treatment method using an 
      established drug class, peroxisome proliferator activated receptor (PPAR) gamma 
      agonists. Previously, sulfasalazine has been shown to prevent release of 
      glutamate from glioma cells and prevent GAS in rodent models. However, raising 
      protein mediated glutamate transport via excitatory amino acid transporter 2 
      (EAAT2) has not been investigated previously to our knowledge. PPAR gamma 
      agonists are known to upregulate functional EAAT2 expression in astrocytes and 
      prevent excitotoxicity caused by glutamate excess. These agents are also known to 
      have anti-neoplastic mechanisms. Herein we discuss and review the potential 
      mechanisms of these drugs and highlight a novel potential treatment for GAS.
CI  - Crown Copyright (c) 2014. Published by Elsevier Ltd. All rights reserved.
FAU - Ching, Jared
AU  - Ching J
AD  - Department of Surgery, The University of Melbourne, Royal Melbourne Hospital, 
      VIC, Australia; Department of Medicine, The University of Melbourne, Royal 
      Melbourne Hospital, VIC, Australia; Institute of Medical Sciences, Foresterhill, 
      University of Aberdeen, Aberdeen AB25 2ZD, UK. Electronic address: 
      jared.ching@nhs.net.
FAU - Amiridis, Stephanie
AU  - Amiridis S
AD  - Department of Surgery, The University of Melbourne, Royal Melbourne Hospital, 
      VIC, Australia; Department of Medicine, The University of Melbourne, Royal 
      Melbourne Hospital, VIC, Australia.
FAU - Stylli, Stanley S
AU  - Stylli SS
AD  - Department of Surgery, The University of Melbourne, Royal Melbourne Hospital, 
      VIC, Australia; Department of Neurosurgery, The Royal Melbourne Hospital, 
      Parkville, VIC, Australia.
FAU - Morokoff, Andrew P
AU  - Morokoff AP
AD  - Department of Surgery, The University of Melbourne, Royal Melbourne Hospital, 
      VIC, Australia; Department of Neurosurgery, The Royal Melbourne Hospital, 
      Parkville, VIC, Australia.
FAU - O'Brien, Terence J
AU  - O'Brien TJ
AD  - Department of Medicine, The University of Melbourne, Royal Melbourne Hospital, 
      VIC, Australia.
FAU - Kaye, Andrew H
AU  - Kaye AH
AD  - Department of Surgery, The University of Melbourne, Royal Melbourne Hospital, 
      VIC, Australia; Department of Neurosurgery, The Royal Melbourne Hospital, 
      Parkville, VIC, Australia.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20141122
PL  - Scotland
TA  - J Clin Neurosci
JT  - Journal of clinical neuroscience : official journal of the Neurosurgical Society 
      of Australasia
JID - 9433352
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Excitatory Amino Acid Transporter 2)
RN  - 0 (PPAR gamma)
RN  - 3KX376GY7L (Glutamic Acid)
SB  - IM
MH  - Animals
MH  - Antineoplastic Agents/*pharmacology
MH  - Brain Neoplasms/complications/*drug therapy
MH  - Excitatory Amino Acid Transporter 2/*metabolism
MH  - Glioblastoma/complications/*drug therapy
MH  - Glutamic Acid/*metabolism
MH  - Humans
MH  - PPAR gamma/*agonists/metabolism
MH  - Seizures/*drug therapy/etiology
OTO - NOTNLM
OT  - Glioma
OT  - Glutamate
OT  - PPAR gamma
OT  - Seizures
EDAT- 2014/12/03 06:00
MHDA- 2016/05/07 06:00
CRDT- 2014/12/03 06:00
PHST- 2014/05/26 00:00 [received]
PHST- 2014/08/30 00:00 [revised]
PHST- 2014/09/02 00:00 [accepted]
PHST- 2014/12/03 06:00 [entrez]
PHST- 2014/12/03 06:00 [pubmed]
PHST- 2016/05/07 06:00 [medline]
AID - S0967-5868(14)00556-6 [pii]
AID - 10.1016/j.jocn.2014.09.001 [doi]
PST - ppublish
SO  - J Clin Neurosci. 2015 Jan;22(1):21-8. doi: 10.1016/j.jocn.2014.09.001. Epub 2014 
      Nov 22.