PMID- 25441980
OWN - NLM
STAT- MEDLINE
DCOM- 20150629
LR  - 20221207
IS  - 1743-6109 (Electronic)
IS  - 1743-6095 (Linking)
VI  - 12
IP  - 2
DP  - 2015 Feb
TI  - The prevalence and the risk factors of testosterone deficiency in newly diagnosed 
      and previously known type 2 diabetic men.
PG  - 389-97
LID - 10.1111/jsm.12777 [doi]
AB  - INTRODUCTION: While the epidemiology of testosterone deficiency has been well 
      described in men with previously known type 2 diabetes mellitus (T2DM), it was 
      less reported in those with untreated, newly diagnosed T2DM. AIM: The aim of this 
      study was to investigate the prevalence and the risk factors of testosterone 
      deficiency of men with newly diagnosed T2DM. METHODS: The cross-sectional study 
      included 105 men (mean age: 61.2 +/- 6.8 years) with previously known T2DM and 
      another 81 (57.8 +/- 8.8 years) with newly diagnosed T2DM. All received health 
      checkup and sex hormone measurement at our institute in 2009. MAIN OUTCOME 
      MEASURES: We calculated the prevalence and explored the risk factors of low total 
      (<300 ng/dL) and free (<6 ng/dL) testosterone in men with newly diagnosed and 
      previously known T2DM. RESULTS: Men with previously known T2DM were older and had 
      higher diastolic pressure and greater fasting glucose. There was no significant 
      difference in total (358.0 [155.0] ng/dL vs. 363.0 [154.0] ng/dL, P=0.68) and 
      free (7.2 [2.5] ng/dL vs. 7.4 [2.4]ng/dL, P=0.84) testosterone and sex-hormone 
      binding globulin (SHBG) (27.3 [22.3]nmol/L vs. 28.7 [14.9]nmol/L, P=0.46). The 
      prevalence of low total and free testosterone was 28.4% and 21.0%, respectively, 
      in men with newly diagnosed T2DM, and was 26.7% and 19.0% in those with 
      previously known T2DM. In men with previously known T2DM, better glycemic control 
      (HbA1c <7%) was associated with a higher level of total testosterone and a lower 
      risk of low total testosterone. Men with newly diagnosed and previously known 
      T2DM shared similar risk factors of low total testosterone, including high HbA1c 
      (>/= 7%), low SHBG (<20 nmol/L), obesity, hyperuricemia, hypertriglycemia, and 
      metabolic syndrome. Elevated prostate-specific antigen was a protective factor of 
      low total testosterone. However, none of these factors was associated with low 
      free testosterone. CONCLUSIONS: The prevalence and the risk factors of 
      testosterone deficiency are similar between newly diagnosed and previously known 
      type 2 diabetic men.
CI  - (c) 2014 International Society for Sexual Medicine.
FAU - Ho, Chen-Hsun
AU  - Ho CH
AD  - Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan 
      University, Taipei, Taiwan; Department of Urology, Taipei Medical 
      University-Shuang Ho Hospital, Taipei, Taiwan.
FAU - Jaw, Fu-Shan
AU  - Jaw FS
FAU - Wu, Chia-Chang
AU  - Wu CC
FAU - Chen, Kuan-Chou
AU  - Chen KC
FAU - Wang, Chih-Yuan
AU  - Wang CY
FAU - Hsieh, Ju-Ton
AU  - Hsieh JT
FAU - Yu, Hong-Jeng
AU  - Yu HJ
FAU - Liu, Shih-Ping
AU  - Liu SP
LA  - eng
PT  - Journal Article
DEP - 20141202
PL  - Netherlands
TA  - J Sex Med
JT  - The journal of sexual medicine
JID - 101230693
RN  - 0 (Blood Glucose)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Sex Hormone-Binding Globulin)
RN  - 0 (hemoglobin A1c protein, human)
RN  - 3XMK78S47O (Testosterone)
RN  - EC 3.4.21.77 (Prostate-Specific Antigen)
SB  - IM
MH  - Age of Onset
MH  - Aged
MH  - Blood Glucose/*metabolism
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/complications/*metabolism/physiopathology
MH  - Glycated Hemoglobin/*metabolism
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Obesity/complications/*metabolism
MH  - Prevalence
MH  - Prostate-Specific Antigen/*metabolism
MH  - Risk Factors
MH  - Sex Hormone-Binding Globulin/metabolism
MH  - Testosterone/*deficiency/metabolism
OTO - NOTNLM
OT  - Hyperuricemia
OT  - Metabolic Syndrome
OT  - Obesity
OT  - Prostate-Specific Antigen
OT  - Testosterone Deficiency
OT  - Type 2 Diabetes Mellitus
EDAT- 2014/12/03 06:00
MHDA- 2015/06/30 06:00
CRDT- 2014/12/03 06:00
PHST- 2014/12/03 06:00 [entrez]
PHST- 2014/12/03 06:00 [pubmed]
PHST- 2015/06/30 06:00 [medline]
AID - S1743-6095(15)30919-X [pii]
AID - 10.1111/jsm.12777 [doi]
PST - ppublish
SO  - J Sex Med. 2015 Feb;12(2):389-97. doi: 10.1111/jsm.12777. Epub 2014 Dec 2.