PMID- 25443177
OWN - NLM
STAT- MEDLINE
DCOM- 20150706
LR  - 20181202
IS  - 1872-7123 (Electronic)
IS  - 0165-1781 (Linking)
VI  - 224
IP  - 3
DP  - 2014 Dec 30
TI  - Neural structure and social dysfunction in individuals at clinical high risk for 
      psychosis.
PG  - 152-8
LID - S0925-4927(14)00208-X [pii]
LID - 10.1016/j.pscychresns.2014.08.008 [doi]
AB  - Individuals at a clinical high risk (CHR) for psychosis have gray matter volume 
      (GMV) abnormalities that are similar to, though less severe than, those in 
      individuals with schizophrenia. Less GMV in schizophrenia is related to worse 
      social cognition and social functioning, but the relationship between GMV and 
      social functioning in CHR individuals has yet to be investigated. The aim of this 
      study was to (1) investigate differences in GMV between healthy controls (HC) and 
      CHR individuals, and (2) evaluate the relationship between GMV and social 
      functioning in these two groups. Participants comprised 22 CHR and 21 HC 
      individuals who completed a structural magnetic resonance imaging (MRI) scan as 
      well as self-reported and interviewer-rated measures of social functioning. 
      Processing and analysis of structural images were completed using voxel based 
      morphometry (VBM). Results showed that the CHR group had less GMV in the left 
      postcentral gyrus, bilateral parahippocampual gyri, and left anterior cingulate 
      cortex. Reduced GMV in the postcentral gyrus and the anterior cingulate was 
      related to self-reported social impairment across the whole group. This study has 
      implications for the neurobiological basis of social dysfunction present before 
      the onset of psychosis.
CI  - Copyright (c) 2014 Elsevier Ireland Ltd. All rights reserved.
FAU - Lincoln, Sarah Hope
AU  - Lincoln SH
AD  - Department of Psychology, Harvard University, William James Hall 1008, Cambridge, 
      MA 02138, USA. Electronic address: sarahhope.lincoln@gmail.com.
FAU - Hooker, Christine I'Lee
AU  - Hooker CI
AD  - Department of Psychology, Harvard University, William James Hall 1008, Cambridge, 
      MA 02138, USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140819
PL  - Ireland
TA  - Psychiatry Res
JT  - Psychiatry research
JID - 7911385
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Cerebral Cortex/*pathology/physiopathology
MH  - Gray Matter/*pathology/physiopathology
MH  - Humans
MH  - Magnetic Resonance Imaging/methods
MH  - Psychotic Disorders/*pathology/physiopathology
MH  - Risk
MH  - *Social Skills
MH  - Young Adult
OTO - NOTNLM
OT  - Gray matter volume
OT  - Magnetic resonance imaging (MRI)
OT  - Neural structure
OT  - Prodromal
OT  - Psychosis
OT  - Social functioning
EDAT- 2014/12/03 06:00
MHDA- 2015/07/07 06:00
CRDT- 2014/12/03 06:00
PHST- 2013/11/03 00:00 [received]
PHST- 2014/05/24 00:00 [revised]
PHST- 2014/08/07 00:00 [accepted]
PHST- 2014/12/03 06:00 [entrez]
PHST- 2014/12/03 06:00 [pubmed]
PHST- 2015/07/07 06:00 [medline]
AID - S0925-4927(14)00208-X [pii]
AID - 10.1016/j.pscychresns.2014.08.008 [doi]
PST - ppublish
SO  - Psychiatry Res. 2014 Dec 30;224(3):152-8. doi: 10.1016/j.pscychresns.2014.08.008. 
      Epub 2014 Aug 19.