PMID- 25444596
OWN - NLM
STAT- MEDLINE
DCOM- 20151124
LR  - 20220316
IS  - 1558-1497 (Electronic)
IS  - 0197-4580 (Linking)
VI  - 36
IP  - 3
DP  - 2015 Mar
TI  - BDNF polymorphism associates with decline in set shifting in Parkinson's disease.
PG  - 1605.e1-6
LID - S0197-4580(14)00536-3 [pii]
LID - 10.1016/j.neurobiolaging.2014.08.023 [doi]
AB  - Parkinson's disease (PD) is a neurodegenerative disorder caused by nigrostriatal 
      dopaminergic degeneration. Brain-derived neurotrophic factor (BDNF) is a key 
      protein in brain plasticity and is particularly important for survival of 
      dopaminergic neurons. The Val66Met polymorphism of BDNF (rs6265) has been 
      associated with functional differences (mainly cognitive) between healthy adults 
      and also with differences in the clinical expression of several other 
      neuropsychiatric illnesses including PD. However, these studies used different 
      outcome measures, have not been replicated, and were cross sectional, making it 
      difficult to establish the role of BDNF in the clinical variability of PD. Here, 
      a large cohort of 384 PD patients were followed up for 2 years, and associations 
      between BDNF genotype and various clinical characteristics were examined. The 
      BDNF Met-allele carriers showed a significantly smaller decline in set shifting 
      during follow-up compared with the homozygous BDNF Val-allele carriers. Contrary 
      to previous assumptions, these results indicate that mental flexibility is one of 
      the cognitive processes that may benefit from the BDNF Met allele in PD patients.
CI  - Copyright (c) 2015 Elsevier Inc. All rights reserved.
FAU - van der Kolk, Nicolien M
AU  - van der Kolk NM
AD  - Department of Neurology, Donders Institute for Brain, Cognition, and Behavior, 
      Radboud University Medical Center, Nijmegen, the Netherlands.
FAU - Speelman, Arlene D
AU  - Speelman AD
AD  - Department of Neurology, Donders Institute for Brain, Cognition, and Behavior, 
      Radboud University Medical Center, Nijmegen, the Netherlands.
FAU - van Nimwegen, Marlies
AU  - van Nimwegen M
AD  - Department of Neurology, Donders Institute for Brain, Cognition, and Behavior, 
      Radboud University Medical Center, Nijmegen, the Netherlands.
FAU - Kessels, Roy P C
AU  - Kessels RP
AD  - Department of Medical Psychology, Radboud University Medical Center, Nijmegen, 
      the Netherlands.
FAU - IntHout, Joanna
AU  - IntHout J
AD  - Department for Health Evidence, Radboud University Medical Center, Nijmegen, the 
      Netherlands.
FAU - Hakobjan, Marina
AU  - Hakobjan M
AD  - Department of Human Genetics, Research Lab for Multifactorial Diseases, Radboud 
      University Medical Center, Nijmegen, the Netherlands.
FAU - Munneke, Marten
AU  - Munneke M
AD  - Department of Neurology, Donders Institute for Brain, Cognition, and Behavior, 
      Radboud University Medical Center, Nijmegen, the Netherlands.
FAU - Bloem, Bastiaan R
AU  - Bloem BR
AD  - Department of Neurology, Donders Institute for Brain, Cognition, and Behavior, 
      Radboud University Medical Center, Nijmegen, the Netherlands.
FAU - van de Warrenburg, Bart P
AU  - van de Warrenburg BP
AD  - Department of Neurology, Donders Institute for Brain, Cognition, and Behavior, 
      Radboud University Medical Center, Nijmegen, the Netherlands. Electronic address: 
      Bart.vandewarrenburg@radboudumc.nl.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140827
PL  - United States
TA  - Neurobiol Aging
JT  - Neurobiology of aging
JID - 8100437
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - AE28F7PNPL (Methionine)
SB  - IM
MH  - Aged
MH  - Alleles
MH  - Brain-Derived Neurotrophic Factor/chemistry/*genetics
MH  - Cohort Studies
MH  - Dopaminergic Neurons/pathology
MH  - Executive Function
MH  - Female
MH  - *Genetic Association Studies
MH  - Genetic Predisposition to Disease/*genetics
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Methionine/genetics
MH  - Middle Aged
MH  - Neuronal Plasticity/genetics
MH  - Parkinson Disease/*genetics/pathology/psychology
MH  - Polymorphism, Genetic/*genetics
OTO - NOTNLM
OT  - BDNF
OT  - Executive function
OT  - Parkinson's disease
EDAT- 2014/12/03 06:00
MHDA- 2015/12/15 06:00
CRDT- 2014/12/03 06:00
PHST- 2014/03/10 00:00 [received]
PHST- 2014/08/14 00:00 [revised]
PHST- 2014/08/22 00:00 [accepted]
PHST- 2014/12/03 06:00 [entrez]
PHST- 2014/12/03 06:00 [pubmed]
PHST- 2015/12/15 06:00 [medline]
AID - S0197-4580(14)00536-3 [pii]
AID - 10.1016/j.neurobiolaging.2014.08.023 [doi]
PST - ppublish
SO  - Neurobiol Aging. 2015 Mar;36(3):1605.e1-6. doi: 
      10.1016/j.neurobiolaging.2014.08.023. Epub 2014 Aug 27.