PMID- 25444646
OWN - NLM
STAT- MEDLINE
DCOM- 20160321
LR  - 20220409
IS  - 1989-1342 (Electronic)
IS  - 1888-4296 (Print)
IS  - 1989-1342 (Linking)
VI  - 8
IP  - 3
DP  - 2015 Jul-Sep
TI  - Corneal Regeneration After Photorefractive Keratectomy: A Review.
PG  - 149-69
LID - S1888-4296(14)00086-7 [pii]
LID - 10.1016/j.optom.2014.09.001 [doi]
AB  - Photorefractive keratectomy (PRK) remodels corneal stroma to compensate 
      refractive errors. The removal of epithelium and the ablation of stroma provoke 
      the disruption of corneal nerves and a release of several peptides from tears, 
      epithelium, stroma and nerves. A myriad of cytokines, growth factors, and matrix 
      metalloproteases participate in the process of corneal wound healing. Their 
      balance will determine if reepithelization and stromal remodeling are 
      appropriate. The final aim is to achieve corneal transparency for restoring 
      corneal function, and a proper visual quality. Therefore, wound-healing response 
      is critical for a successful refractive surgery. Our goal is to provide an 
      overview into how corneal wounding develops following PRK. We will also review 
      the influence of intraoperative application of mitomycin C, bandage contact 
      lenses, anti-inflammatory and other drugs in preventing corneal haze and post-PRK 
      pain.
CI  - Copyright (c) 2014 Spanish General Council of Optometry. Published by Elsevier 
      Espana. All rights reserved.
FAU - Tomas-Juan, Javier
AU  - Tomas-Juan J
AD  - Department of Visual Science, VallmedicVision International Eye Clinic, Andorra. 
      Electronic address: javier.tomas@vallmedicvision.com.
FAU - Murueta-Goyena Larranaga, Ane
AU  - Murueta-Goyena Larranaga A
AD  - Collaborator Researcher at Department of Neuroscience, University of Basque 
      Country, Leioa, Spain.
FAU - Hanneken, Ludger
AU  - Hanneken L
AD  - Department of Visual Science, VallmedicVision International Eye Clinic, Andorra.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20141023
PL  - Spain
TA  - J Optom
JT  - Journal of optometry
JID - 101482903
RN  - 0 (Alkylating Agents)
RN  - 0 (Anti-Inflammatory Agents)
RN  - 50SG953SK6 (Mitomycin)
SB  - IM
MH  - Alkylating Agents/administration & dosage
MH  - Anti-Inflammatory Agents/therapeutic use
MH  - Contact Lenses
MH  - Cornea/innervation/physiology
MH  - Corneal Opacity/etiology/prevention & control
MH  - Humans
MH  - Lasers, Excimer/therapeutic use
MH  - Mitomycin/administration & dosage
MH  - Photorefractive Keratectomy/*methods
MH  - Postoperative Complications/prevention & control
MH  - Regeneration/physiology
MH  - Wound Healing/*physiology
PMC - PMC4502084
OTO - NOTNLM
OT  - Contact lenses
OT  - Cornea
OT  - Curacion de heridas
OT  - Cornea
OT  - Lentes de contacto
OT  - Photorefractive keratectomy
OT  - Queratectomia fotorrefractiva
OT  - Wound healing
EDAT- 2014/12/03 06:00
MHDA- 2016/03/22 06:00
PMCR- 2014/10/23
CRDT- 2014/12/03 06:00
PHST- 2014/06/28 00:00 [received]
PHST- 2014/08/01 00:00 [revised]
PHST- 2014/12/03 06:00 [entrez]
PHST- 2014/12/03 06:00 [pubmed]
PHST- 2016/03/22 06:00 [medline]
PHST- 2014/10/23 00:00 [pmc-release]
AID - S1888-4296(14)00086-7 [pii]
AID - 10.1016/j.optom.2014.09.001 [doi]
PST - ppublish
SO  - J Optom. 2015 Jul-Sep;8(3):149-69. doi: 10.1016/j.optom.2014.09.001. Epub 2014 
      Oct 23.