PMID- 25445220
OWN - NLM
STAT- MEDLINE
DCOM- 20150220
LR  - 20141216
IS  - 1879-0631 (Electronic)
IS  - 0024-3205 (Linking)
VI  - 120
DP  - 2015 Jan 1
TI  - Prenatal zinc reduces stress response in adult rat offspring exposed to 
      lipopolysaccharide during gestation.
PG  - 54-60
LID - S0024-3205(14)00893-5 [pii]
LID - 10.1016/j.lfs.2014.10.019 [doi]
AB  - AIMS: Previous investigations by our group have shown that prenatal treatment 
      with lipopolysaccharide (LPS; 100 mug/kg, intraperitoneally) on gestation day (GD) 
      9.5 in rats, which mimics infections by Gram-negative bacteria, induces short- 
      and long-term behavioral and neuroimmune changes in the offspring. Because LPS 
      induces hypozincemia, dams were treated with zinc after LPS in an attempt to 
      prevent or ameliorate the impairments induced by prenatal LPS exposure. LPS can 
      also interfere with hypothalamic-pituitary-adrenal (HPA) axis development; thus, 
      behavioral and neuroendocrine parameters linked to HPA axis were evaluated in 
      adult offspring after a restraint stress session. MAIN METHODS: We prenatally 
      exposed Wistar rats to LPS (100 mug/kg, intraperitoneally, on GD 9.5). One hour 
      later they received zinc (ZnSO4, 2 mg/kg, subcutaneously). Adult female offspring 
      that were in metestrus/diestrus were submitted to a 2 h restraint stress session. 
      Immediately after the stressor, 22 kHz ultrasonic vocalizations, open field 
      behavior, serum corticosterone and brain-derived neurotrophic factor (BDNF) 
      levels, and striatal and hypothalamic neurotransmitter and metabolite levels were 
      assessed. KEY FINDINGS: Offspring that received prenatal zinc after LPS presented 
      longer periods in silence, increased locomotion, and reduced serum corticosterone 
      and striatal norepinephrine turnover compared with rats treated with LPS and 
      saline. Prenatal zinc reduced acute restraint stress response in adult rats 
      prenatally exposed to LPS. SIGNIFICANCE: Our findings suggest a potential 
      beneficial effect of prenatal zinc, in which the stress response was reduced in 
      offspring that were stricken with infectious/inflammatory processes during 
      gestation.
CI  - Copyright (c) 2014 Elsevier Inc. All rights reserved.
FAU - Galvao, Marcella C
AU  - Galvao MC
AD  - Department of Pathology, School of Veterinary Medicine, University of Sao Paulo, 
      Av. Prof. Dr. Orlando Marques de Paiva, 87, Sao Paulo, SP 05508-270, Brazil.
FAU - Chaves-Kirsten, Gabriela P
AU  - Chaves-Kirsten GP
AD  - Department of Pathology, School of Veterinary Medicine, University of Sao Paulo, 
      Av. Prof. Dr. Orlando Marques de Paiva, 87, Sao Paulo, SP 05508-270, Brazil.
FAU - Queiroz-Hazarbassanov, Nicolle
AU  - Queiroz-Hazarbassanov N
AD  - Department of Pathology, School of Veterinary Medicine, University of Sao Paulo, 
      Av. Prof. Dr. Orlando Marques de Paiva, 87, Sao Paulo, SP 05508-270, Brazil.
FAU - Carvalho, Virginia M
AU  - Carvalho VM
AD  - Department of Pathology, School of Veterinary Medicine, University of Sao Paulo, 
      Av. Prof. Dr. Orlando Marques de Paiva, 87, Sao Paulo, SP 05508-270, Brazil.
FAU - Bernardi, Maria M
AU  - Bernardi MM
AD  - Environmental and Experimental Pathology, Paulista University, Rua Dr. Bacelar, 
      1212, Sao Paulo, 04026-002, Brazil.
FAU - Kirsten, Thiago B
AU  - Kirsten TB
AD  - Department of Pathology, School of Veterinary Medicine, University of Sao Paulo, 
      Av. Prof. Dr. Orlando Marques de Paiva, 87, Sao Paulo, SP 05508-270, Brazil; 
      Environmental and Experimental Pathology, Paulista University, Rua Dr. Bacelar, 
      1212, Sao Paulo, 04026-002, Brazil. Electronic address: thik@hotmail.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141105
PL  - Netherlands
TA  - Life Sci
JT  - Life sciences
JID - 0375521
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Lipopolysaccharides)
RN  - J41CSQ7QDS (Zinc)
RN  - W980KJ009P (Corticosterone)
SB  - IM
MH  - Animals
MH  - Behavior, Animal
MH  - Brain-Derived Neurotrophic Factor/blood
MH  - Corpus Striatum/metabolism
MH  - Corticosterone/blood
MH  - Female
MH  - Hypothalamo-Hypophyseal System/metabolism
MH  - Hypothalamus/metabolism
MH  - Inflammation
MH  - Lipopolysaccharides/*chemistry
MH  - *Maternal Exposure
MH  - Pituitary-Adrenal System/metabolism
MH  - Pregnancy
MH  - Pregnancy, Animal
MH  - Prenatal Exposure Delayed Effects
MH  - Rats
MH  - Rats, Wistar
MH  - Stress, Psychological/*physiopathology
MH  - Zinc/chemistry/*therapeutic use
OTO - NOTNLM
OT  - Hypothalamic-pituitary-adrenal axis
OT  - Maternal immune activation
OT  - Norepinephrine
OT  - Open field behavior
OT  - Prenatal infection
OT  - Ultrasonic vocalizations
EDAT- 2014/12/03 06:00
MHDA- 2015/02/24 06:00
CRDT- 2014/12/03 06:00
PHST- 2014/09/16 00:00 [received]
PHST- 2014/10/14 00:00 [revised]
PHST- 2014/10/21 00:00 [accepted]
PHST- 2014/12/03 06:00 [entrez]
PHST- 2014/12/03 06:00 [pubmed]
PHST- 2015/02/24 06:00 [medline]
AID - S0024-3205(14)00893-5 [pii]
AID - 10.1016/j.lfs.2014.10.019 [doi]
PST - ppublish
SO  - Life Sci. 2015 Jan 1;120:54-60. doi: 10.1016/j.lfs.2014.10.019. Epub 2014 Nov 5.