PMID- 25445785
OWN - NLM
STAT- MEDLINE
DCOM- 20150819
LR  - 20151026
IS  - 1872-678X (Electronic)
IS  - 0165-0270 (Linking)
VI  - 239
DP  - 2015 Jan 15
TI  - Optimized protocol for high resolution functional magnetic resonance imaging at 
      3T using single-shot echo planar imaging.
PG  - 170-82
LID - S0165-0270(14)00381-1 [pii]
LID - 10.1016/j.jneumeth.2014.10.014 [doi]
AB  - BACKGROUND: To translate highly accelerated EPI-fMRI protocols as commonly used 
      at ultra-high field strengths to clinical 3T settings. NEW METHOD: EPI protocols 
      with increasing matrix sizes and parallel imaging (PI) factors were tested in two 
      separate fMRI studies, a simple motor-task and a complex motivation-task 
      experiment with focus on the sensorimotor cortex (SMC) and the nucleus accumbens 
      (NAcc), respectively. RESULTS: By increasing the matrix size and the PI-factor 
      simultaneously, BOLD-sensitivity in terms of maximal t-values and numbers of 
      activated clusters was uncompromised in single individuals in both fMRI 
      experiments. In the SMC, the multi-subject analysis revealed an increase of 66% 
      of the maximal t-value whereby the number of activated clusters was increased by 
      a factor of 3.3 when the matrix size (PI-factor) was increased from 96x96 (R=2) 
      to 192x192 (R=4). In the NAcc, the number of activated clusters increased from 5 
      to 7 whereby the maximal t-value remained unaffected when the matrix size 
      (PI-factor) was increased from 96x96 (R=2) to 160x160 (R=3). COMPARISON WITH 
      EXISTING METHOD: Using the proposed high-resolution EPI protocol, spatial 
      blurring was clearly reduced. Further, BOLD sensitivity was clearly improved in 
      multi-subject analyses and remained unaffected in single individuals compared to 
      using the standard protocols. CONCLUSIONS: Conventionally used matrix sizes 
      (PI-factors) might be non-optimal for some applications sacrificing BOLD spatial 
      specificity. We recommend using the proposed high-resolution protocols applicable 
      in detecting robust BOLD activation in fMRI.
CI  - Copyright (c) 2014 Elsevier B.V. All rights reserved.
FAU - Domsch, Sebastian
AU  - Domsch S
AD  - Department of Computer Assisted Clinical Medicine, Medical Faculty Mannheim, 
      Heidelberg University, Germany. Electronic address: 
      sebastian.domsch@medma.uni-heidelberg.de.
FAU - Zapp, Jascha
AU  - Zapp J
AD  - Department of Computer Assisted Clinical Medicine, Medical Faculty Mannheim, 
      Heidelberg University, Germany.
FAU - Schad, Lothar R
AU  - Schad LR
AD  - Department of Computer Assisted Clinical Medicine, Medical Faculty Mannheim, 
      Heidelberg University, Germany.
FAU - Nees, Frauke
AU  - Nees F
AD  - Department of Cognitive and Clinical Neuroscience, Central Institute of Mental 
      Health, Medical Faculty Mannheim, Heidelberg University, Germany.
FAU - Hill, Holger
AU  - Hill H
AD  - Department of Addictive Behavior and Addiction Medicine, Central Institute of 
      Mental Health, Medical Faculty Mannheim, Heidelberg University, Germany.
FAU - Hermann, Derik
AU  - Hermann D
AD  - Department of Addictive Behavior and Addiction Medicine, Central Institute of 
      Mental Health, Medical Faculty Mannheim, Heidelberg University, Germany.
FAU - Mann, Karl
AU  - Mann K
AD  - Department of Addictive Behavior and Addiction Medicine, Central Institute of 
      Mental Health, Medical Faculty Mannheim, Heidelberg University, Germany.
FAU - Vollstadt-Klein, Sabine
AU  - Vollstadt-Klein S
AD  - Department of Addictive Behavior and Addiction Medicine, Central Institute of 
      Mental Health, Medical Faculty Mannheim, Heidelberg University, Germany.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141029
PL  - Netherlands
TA  - J Neurosci Methods
JT  - Journal of neuroscience methods
JID - 7905558
SB  - IM
MH  - Adult
MH  - Brain/*anatomy & histology/*blood supply/physiology
MH  - *Brain Mapping
MH  - *Echo-Planar Imaging
MH  - Female
MH  - Humans
MH  - *Imaging, Three-Dimensional
MH  - Linear Models
MH  - *Magnetic Resonance Imaging
MH  - Male
MH  - Motivation
MH  - Psychomotor Performance
MH  - Young Adult
OTO - NOTNLM
OT  - Motivation
OT  - Nucleus accumbens
OT  - Parallel imaging
OT  - Somatosensori motor cortex
OT  - Spatial specificity
OT  - fMRI
EDAT- 2014/12/03 06:00
MHDA- 2015/08/20 06:00
CRDT- 2014/12/03 06:00
PHST- 2014/06/10 00:00 [received]
PHST- 2014/10/17 00:00 [revised]
PHST- 2014/10/18 00:00 [accepted]
PHST- 2014/12/03 06:00 [entrez]
PHST- 2014/12/03 06:00 [pubmed]
PHST- 2015/08/20 06:00 [medline]
AID - S0165-0270(14)00381-1 [pii]
AID - 10.1016/j.jneumeth.2014.10.014 [doi]
PST - ppublish
SO  - J Neurosci Methods. 2015 Jan 15;239:170-82. doi: 10.1016/j.jneumeth.2014.10.014. 
      Epub 2014 Oct 29.