PMID- 25445818
OWN - NLM
STAT- MEDLINE
DCOM- 20150721
LR  - 20151119
IS  - 1878-5891 (Electronic)
IS  - 0378-5955 (Linking)
VI  - 318
DP  - 2014 Dec
TI  - Biological correlates of tinnitus-related distress: an exploratory study.
PG  - 23-30
LID - S0378-5955(14)00171-3 [pii]
LID - 10.1016/j.heares.2014.10.007 [doi]
AB  - During the process of tinnitus diagnostics, various psychometric instruments are 
      used to measure tinnitus-related distress. The aim of present work was to explore 
      whether candidates for biological correlates of the tinnitus-related distress 
      could be found in peripheral blood of patients and if so, whether there was 
      association between them and psychometric scores that reflect tinnitus-related 
      distress. The concentrations of interleukin-1beta (IL1beta), interleukin-6 (IL6), tumor 
      necrosis factor-alpha (TNFalpha) and a brain-derived neutrotrophic factor (BDNF) were 
      measured in serum of 30 patients diagnosed with chronic tinnitus and tested for 
      correlation with psychometric scores collected on the same day. Spearman's 
      correlation analyses detected significant positive association between the 
      concentrations of tumor necrosis factor alpha and tinnitus loudness, total perceived 
      stress, tension and depression and a negative association between tumor necrosis 
      factor alpha and a psychometric score "joy". Concentrations of interleukin-1beta 
      correlated with the awareness grade of tinnitus. The correlation between visual 
      analogue scale (VAS) "loudness" and tumor necrosis factor alpha as well as between 
      "joy" and tumor necrosis factor alpha retained their significance (p < 0.00167) after 
      the application of Bonferroni correction for multiple testing. Partial 
      correlations removing the effects of age, hearing loss and the duration of 
      tinnitus verified the results obtained using Spearman correlation. We conclude 
      that measuring the concentrations of selected circulating cytokines could 
      possibly become an additional objective element of tinnitus diagnostics in the 
      future.
CI  - Copyright (c) 2014 Elsevier B.V. All rights reserved.
FAU - Szczepek, Agnieszka J
AU  - Szczepek AJ
AD  - Molecular Biology Research Laboratory, Department of Otorhinolaryngology, Charite 
      - Universitatsmedizin Berlin, Campus Charite Mitte, Berlin, Germany.
FAU - Haupt, Heidemarie
AU  - Haupt H
AD  - Molecular Biology Research Laboratory, Department of Otorhinolaryngology, Charite 
      - Universitatsmedizin Berlin, Campus Charite Mitte, Berlin, Germany; Tinnitus 
      Center, Charite - Universitatsmedizin Berlin, Campus Charite Mitte, Berlin, 
      Germany.
FAU - Klapp, Burghard F
AU  - Klapp BF
AD  - Department of Internal Medicine and Psychosomatics, Charite - Universitatsmedizin 
      Berlin, Campus Charite Mitte, Berlin, Germany.
FAU - Olze, Heidi
AU  - Olze H
AD  - Molecular Biology Research Laboratory, Department of Otorhinolaryngology, Charite 
      - Universitatsmedizin Berlin, Campus Charite Mitte, Berlin, Germany; Department 
      of Otorhinolaryngology, Charite - Universitatsmedizin Berlin, Campus Charite 
      Mitte and Campus Charite Virchow, Berlin, Germany.
FAU - Mazurek, Birgit
AU  - Mazurek B
AD  - Molecular Biology Research Laboratory, Department of Otorhinolaryngology, Charite 
      - Universitatsmedizin Berlin, Campus Charite Mitte, Berlin, Germany; Tinnitus 
      Center, Charite - Universitatsmedizin Berlin, Campus Charite Mitte, Berlin, 
      Germany. Electronic address: birgit.mazurek@charite.de.
LA  - eng
PT  - Journal Article
DEP - 20141028
PL  - Netherlands
TA  - Hear Res
JT  - Hearing research
JID - 7900445
RN  - 0 (Biomarkers)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Interleukin-1beta)
RN  - 0 (Interleukin-6)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Biomarkers/blood
MH  - Brain-Derived Neurotrophic Factor/blood
MH  - Case-Control Studies
MH  - Female
MH  - Humans
MH  - Interleukin-1beta/blood
MH  - Interleukin-6/blood
MH  - Male
MH  - Middle Aged
MH  - *Psychometrics
MH  - *Stress, Physiological
MH  - Tinnitus/*blood/diagnosis/*psychology
MH  - Tumor Necrosis Factor-alpha/blood
MH  - Young Adult
EDAT- 2014/12/03 06:00
MHDA- 2015/07/22 06:00
CRDT- 2014/12/03 06:00
PHST- 2014/06/30 00:00 [received]
PHST- 2014/10/10 00:00 [revised]
PHST- 2014/10/15 00:00 [accepted]
PHST- 2014/12/03 06:00 [entrez]
PHST- 2014/12/03 06:00 [pubmed]
PHST- 2015/07/22 06:00 [medline]
AID - S0378-5955(14)00171-3 [pii]
AID - 10.1016/j.heares.2014.10.007 [doi]
PST - ppublish
SO  - Hear Res. 2014 Dec;318:23-30. doi: 10.1016/j.heares.2014.10.007. Epub 2014 Oct 
      28.