PMID- 25446001
OWN - NLM
STAT- MEDLINE
DCOM- 20150821
LR  - 20191210
IS  - 1872-6240 (Electronic)
IS  - 0006-8993 (Linking)
VI  - 1595
DP  - 2015 Jan 21
TI  - Ligustilide prevents cognitive impairment and attenuates neurotoxicity in 
      D-galactose induced aging mice brain.
PG  - 19-28
LID - S0006-8993(14)01387-0 [pii]
LID - 10.1016/j.brainres.2014.10.012 [doi]
AB  - Ligustilide (LIG) is a principal active ingredient of traditional Chinese 
      medicine, Radix Angelica sinensis, which has versatile pharmacological activities 
      including neuroprotection. Previous studies have demonstrated that LIG has 
      beneficial effects on cognition deficits associated with cerebral damage or 
      neurodegenerative disorders. In present study, we investigated the 
      neuroprotective effect of LIG on cognitive impairment and neurotoxicity in the 
      brain of aging mouse induced by d-galactose (d-gal). The aging model mice were 
      induced by subcutaneous (S.C.) injection of d-gal once daily for 8 weeks and LIG 
      (80 mg/kg) was simultaneously administered orally. The Morris water maze (MWM) 
      test was used to assess the spatial learning and memory abilities. The activity 
      of Na(+)-K(+)-ATPase and the content of lipid peroxidation product 
      malondialdehyde (MDA) in brain were examined. The levels of glial fibrillary 
      acidic protein (GFAP), growth-associated protein GAP-43, and cleaved caspase-3 in 
      brain were also determined by immunohistochemistry. The MWM test showed that LIG 
      administration markedly improved behavioral performance of d-gal treated mice. 
      This action could be partly explained by the results that LIG reduced the level 
      of MDA as well as increased the activity of Na(+)-K(+)-ATPase in the brain of 
      d-gal induced aging mice. Moreover, LIG significantly raised the expression of 
      GAP-43 and reduced cleaved caspase-3 and GFAP levels in the brain of d-gal 
      treated mice. These results demonstrated that LIG improves d-gal-induced 
      cognitive dysfunction and brain toxicity, which suggests that LIG may be 
      developed as a new medicine for the treatment of aged-related conditions.
CI  - Copyright (c) 2014 Elsevier B.V. All rights reserved.
FAU - Li, Jie-Jia
AU  - Li JJ
AD  - School of Medicine, Nantong University, Nantong 226001, China; Department of 
      Neurochemistry, Institute for Nautical Medicine, Nantong University, 19 Qixiu 
      Road, Nantong 226001, China.
FAU - Zhu, Qing
AU  - Zhu Q
AD  - School of Pharmacy, Nantong University, Nantong 226001, China.
FAU - Lu, Ya-Peng
AU  - Lu YP
AD  - Department of Neurochemistry, Institute for Nautical Medicine, Nantong 
      University, 19 Qixiu Road, Nantong 226001, China.
FAU - Zhao, Peng
AU  - Zhao P
AD  - Department of Neurochemistry, Institute for Nautical Medicine, Nantong 
      University, 19 Qixiu Road, Nantong 226001, China.
FAU - Feng, Zhan-Bo
AU  - Feng ZB
AD  - Department of Neurochemistry, Institute for Nautical Medicine, Nantong 
      University, 19 Qixiu Road, Nantong 226001, China.
FAU - Qian, Zhong-Ming
AU  - Qian ZM
AD  - Department of Neurochemistry, Institute for Nautical Medicine, Nantong 
      University, 19 Qixiu Road, Nantong 226001, China. Electronic address: 
      bczmqian@polyu.edu.hk.
FAU - Zhu, Li
AU  - Zhu L
AD  - Department of Neurochemistry, Institute for Nautical Medicine, Nantong 
      University, 19 Qixiu Road, Nantong 226001, China. Electronic address: 
      zhulili65@126.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141018
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (GAP-43 Protein)
RN  - 0 (Glial Fibrillary Acidic Protein)
RN  - 0 (Neuroprotective Agents)
RN  - 4431-01-0 (ligustilide)
RN  - 4Y8F71G49Q (Malondialdehyde)
RN  - EC 7.2.2.13 (Sodium-Potassium-Exchanging ATPase)
RN  - OL659KIY4X (4-Butyrolactone)
RN  - X2RN3Q8DNE (Galactose)
SB  - IM
MH  - 4-Butyrolactone/*analogs & derivatives/therapeutic use
MH  - Aging/drug effects
MH  - Animals
MH  - Brain/drug effects/metabolism
MH  - Cognition Disorders/*etiology/*prevention & control
MH  - GAP-43 Protein/metabolism
MH  - Galactose/toxicity
MH  - Gene Expression Regulation/drug effects
MH  - Glial Fibrillary Acidic Protein/metabolism
MH  - Male
MH  - Malondialdehyde/metabolism
MH  - Maze Learning/drug effects
MH  - Mice
MH  - Mice, Inbred ICR
MH  - Neuroprotective Agents/*therapeutic use
MH  - Neurotoxicity Syndromes/*complications/etiology
MH  - Sodium-Potassium-Exchanging ATPase/metabolism
MH  - Statistics, Nonparametric
OTO - NOTNLM
OT  - Aging
OT  - Ligustilide
OT  - Morris water maze
OT  - Neurotoxicity
OT  - d-Galactose
EDAT- 2014/12/03 06:00
MHDA- 2015/08/22 06:00
CRDT- 2014/12/03 06:00
PHST- 2014/08/26 00:00 [received]
PHST- 2014/10/07 00:00 [revised]
PHST- 2014/10/08 00:00 [accepted]
PHST- 2014/12/03 06:00 [entrez]
PHST- 2014/12/03 06:00 [pubmed]
PHST- 2015/08/22 06:00 [medline]
AID - S0006-8993(14)01387-0 [pii]
AID - 10.1016/j.brainres.2014.10.012 [doi]
PST - ppublish
SO  - Brain Res. 2015 Jan 21;1595:19-28. doi: 10.1016/j.brainres.2014.10.012. Epub 2014 
      Oct 18.