PMID- 25446251
OWN - NLM
STAT- MEDLINE
DCOM- 20151230
LR  - 20221109
IS  - 1089-8611 (Electronic)
IS  - 1089-8603 (Linking)
VI  - 46
DP  - 2015 Apr 30
TI  - Hydrogen sulphide and the kidney: important roles in renal physiology and 
      pathogenesis and treatment of kidney injury and disease.
PG  - 55-65
LID - S1089-8603(14)00462-5 [pii]
LID - 10.1016/j.niox.2014.10.004 [doi]
AB  - The kidney is an essential mammalian organ that serves to filter toxins and 
      metabolic by-products out of the blood, which are then excreted through urine. 
      Hydrogen sulphide (H2S) is a recently characterized, endogenous gaseous molecule 
      with important physiological roles. Many interesting roles continue to be 
      identified for H2S related specifically to the kidney. The current review 
      discusses how production and action of H2S influences normal physiology of the 
      kidney. We investigate as well the many roles H2S plays in the pathogenesis and 
      treatment of kidney injury and disease, such as chronic kidney disease (CKD), 
      ureteral obstruction (UO), hyperhomocysteinaemia (HHcy), drug-induced 
      nephrotoxicity (DIN) and renal ischaemia reperfusion injury (IRI). We suggest 
      that H2S plays a complex and essential role in the normal function of the kidney 
      and dysregulation of H2S production can directly or indirectly contribute to the 
      pathogenesis of renal disease and injury. Also, H2S could be a promising 
      potential therapeutic treatment to decrease the severity of several renal 
      diseases. Further research will identify increasingly important and complex roles 
      for H2S in renal physiology and how H2S can be effectively utilized to improve 
      clinical outcomes of renal disease.
CI  - Copyright (c) 2014 Elsevier Inc. All rights reserved.
FAU - Lobb, I
AU  - Lobb I
AD  - Department of Microbiology and Immunology, Western University, London, Ontario, 
      Canada; Matthew Mailing Center for Translational Transplant Studies, London 
      Health Sciences Center, Western University, London, Ontario, Canada.
FAU - Sonke, E
AU  - Sonke E
AD  - Matthew Mailing Center for Translational Transplant Studies, London Health 
      Sciences Center, Western University, London, Ontario, Canada; Department of 
      Anatomy and Cell Biology, Western University, London, Ontario, Canada.
FAU - Aboalsamh, G
AU  - Aboalsamh G
AD  - Matthew Mailing Center for Translational Transplant Studies, London Health 
      Sciences Center, Western University, London, Ontario, Canada; Department of 
      Surgery, Western University, London, Ontario, Canada; Multi-Organ Transplant 
      Program, London Health Sciences Center, Western University, London, Ontario, 
      Canada.
FAU - Sener, A
AU  - Sener A
AD  - Department of Microbiology and Immunology, Western University, London, Ontario, 
      Canada; Matthew Mailing Center for Translational Transplant Studies, London 
      Health Sciences Center, Western University, London, Ontario, Canada; Department 
      of Surgery, Western University, London, Ontario, Canada; Multi-Organ Transplant 
      Program, London Health Sciences Center, Western University, London, Ontario, 
      Canada. Electronic address: alp.Sener@lhsc.on.ca.
LA  - eng
GR  - 201310GSD-327849-210205/Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20141024
PL  - United States
TA  - Nitric Oxide
JT  - Nitric oxide : biology and chemistry
JID - 9709307
RN  - YY9FVM7NSN (Hydrogen Sulfide)
SB  - IM
MH  - Animals
MH  - Humans
MH  - Hydrogen Sulfide/*metabolism/*pharmacology
MH  - Kidney/*drug effects/metabolism/*physiology
MH  - Kidney Diseases/*drug therapy/metabolism/*physiopathology
OTO - NOTNLM
OT  - Hydrogen sulphide
OT  - Renal disease
OT  - Renal physiology
EDAT- 2014/12/03 06:00
MHDA- 2015/12/31 06:00
CRDT- 2014/12/03 06:00
PHST- 2014/09/02 00:00 [received]
PHST- 2014/10/10 00:00 [revised]
PHST- 2014/10/20 00:00 [accepted]
PHST- 2014/12/03 06:00 [entrez]
PHST- 2014/12/03 06:00 [pubmed]
PHST- 2015/12/31 06:00 [medline]
AID - S1089-8603(14)00462-5 [pii]
AID - 10.1016/j.niox.2014.10.004 [doi]
PST - ppublish
SO  - Nitric Oxide. 2015 Apr 30;46:55-65. doi: 10.1016/j.niox.2014.10.004. Epub 2014 
      Oct 24.