PMID- 25446461
OWN - NLM
STAT- MEDLINE
DCOM- 20150629
LR  - 20181202
IS  - 1872-7123 (Electronic)
IS  - 0165-1781 (Linking)
VI  - 220
IP  - 3
DP  - 2014 Dec 30
TI  - Increase of circulating BDNF levels and its relation to improvement of physical 
      fitness following 12 weeks of combined exercise in chronic patients with 
      schizophrenia: a pilot study.
PG  - 792-6
AB  - Brain-derived neurotrophic factor (BDNF), the most abundant of neurotrophins in 
      the brain, is known to be responsible for maintenance of neurons has been 
      implicated in the pathology of schizophrenia. In the present pilot study, we 
      investigated the effect of a combined exercise program on circulating BDNF 
      expression and the relationship between BDNF and improvements in physical 
      fitness. Twenty-four patients with schizophrenia participated in the exercise 
      intervention, three nonconsecutive days per week for 12 weeks. The resistance 
      exercise program used the elastic band for eight different exercises for 25 min, 
      and the aerobic exercise consisted of moderate walking for 25 min. After the 
      training program, there were positive improvements in body composition and blood 
      pressure. Also, there was significant improvement in leg strength, cardiovascular 
      fitness, balance, and jump. Serum BDNF values had significantly increased 
      following the combined exercise program. The elevation in serum BDNF 
      concentrations correlated significantly with improvements in cardiovascular 
      fitness and leg strength. These results suggest that exercise induced modulation 
      of BDNF may play an important role in developing non-pharmacological treatment 
      for chronic schizophrenic patients. In addition, these preliminary results serve 
      to generate further hypothesis and facilitate the planning the exercise training 
      program and management of participants.
FAU - Kim, Hee-jae
AU  - Kim HJ
FAU - Song, Bong-kil
AU  - Song BK
FAU - So, Byunghun
AU  - So B
FAU - Lee, On
AU  - Lee O
FAU - Song, Wook
AU  - Song W
FAU - Kim, Yeonsoo
AU  - Kim Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - Psychiatry Res
JT  - Psychiatry research
JID - 7911385
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
CIN - Psychiatry Res. 2015 Aug 15;228(2):233. PMID: 26051419
MH  - Adult
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Chronic Disease
MH  - Cross-Sectional Studies
MH  - Exercise/*physiology/psychology
MH  - Exercise Therapy/*methods
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Physical Fitness/*physiology
MH  - Pilot Projects
MH  - Schizophrenia/*blood/*therapy
EDAT- 2014/12/03 06:00
MHDA- 2015/06/30 06:00
CRDT- 2014/12/03 06:00
PHST- 2014/05/28 00:00 [received]
PHST- 2014/09/01 00:00 [revised]
PHST- 2014/09/28 00:00 [accepted]
PHST- 2014/12/03 06:00 [entrez]
PHST- 2014/12/03 06:00 [pubmed]
PHST- 2015/06/30 06:00 [medline]
AID - S0165-1781(14)00818-X [pii]
AID - 10.1016/j.psychres.2014.09.020 [doi]
PST - ppublish
SO  - Psychiatry Res. 2014 Dec 30;220(3):792-6. doi: 10.1016/j.psychres.2014.09.020.