PMID- 25446594
OWN - NLM
STAT- MEDLINE
DCOM- 20150925
LR  - 20161125
IS  - 1872-7573 (Electronic)
IS  - 0378-8741 (Linking)
VI  - 158 Pt A
DP  - 2014 Dec 2
TI  - Hepatoprotective activity of ginsenosides from Panax ginseng adventitious roots 
      against carbon tetrachloride treated hepatic injury in rats.
PG  - 442-6
LID - S0378-8741(14)00757-0 [pii]
LID - 10.1016/j.jep.2014.10.047 [doi]
AB  - ETHNOPHARMACOLOGICAL RELEVANCE: Ginseng (Panax ginseng C. A. Meyer) has a 
      beneficial role in the treatment of various diseases including liver disorders 
      like acute/chronic hepatotoxicity, hepatitis, hepatic fibrosis/cirrhosis and 
      hepatocellular carcinoma. MATERIALS AND METHODS: Tissue culture raised mountain 
      ginseng adventitious root (TCMGARs) extract with ginsenosides in abundance was 
      used as an experimental material. 'Sprague-Dawley' male rats were used as 
      experimental systems and were fed with TCMGARs extracts at doses of 30, 100, 
      300mg/kg body weight for two weeks to test the effect on carbon tetrachloride 
      (CCl4) induced acute liver damage. Field cultivated Korean ginseng root extract 
      fed rats (100mg/kg) were used as positive control. Plasma enzyme levels, alanine 
      aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase 
      (ALP) were assessed. Glutathione (GSH) and malondialdehyde (MDA) concentrations 
      were also evaluated. RESULTS: TCMGARs extracts remarkably prevented the elevation 
      of ALT, AST, ALP and liver peroxides in CCl4-treated rats. Hepatic glutathione 
      levels were significantly increased by the treatment with the extracts in 
      experimental groups. CONCLUSION: The TCMGARs rich in varied ginsenosides can 
      afford protection against CCl4-induced hepatocellular injury.
CI  - Copyright (c) 2014 Elsevier Ireland Ltd. All rights reserved.
FAU - Niranjana Murthy, Hosakatte
AU  - Niranjana Murthy H
AD  - Research Center for the Development of Advanced Horticultural Technology, 
      Chungbuk National University, Cheongju 361-763, Republic of Korea; Department of 
      Botany, Karnatak University, Dharwad 580003, India. Electronic address: 
      nmurthy60@yahoo.co.in.
FAU - Dandin, Vijayalaxmi S
AU  - Dandin VS
AD  - Department of Botany, Karnatak University, Dharwad 580003, India.
FAU - Yoeup Paek, Kee
AU  - Yoeup Paek K
AD  - Research Center for the Development of Advanced Horticultural Technology, 
      Chungbuk National University, Cheongju 361-763, Republic of Korea. Electronic 
      address: paekky@chungbuk.ac.kr.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141031
PL  - Ireland
TA  - J Ethnopharmacol
JT  - Journal of ethnopharmacology
JID - 7903310
RN  - 0 (Ginsenosides)
SB  - IM
MH  - Animals
MH  - Carbon Tetrachloride Poisoning/*prevention & control
MH  - Chemical and Drug Induced Liver Injury/etiology/*prevention & control
MH  - Ginsenosides/*pharmacology
MH  - Male
MH  - Panax/*chemistry
MH  - Plant Roots/*chemistry
MH  - Rats
MH  - Rats, Sprague-Dawley
OTO - NOTNLM
OT  - Ginsenosides
OT  - Glutathione
OT  - Hepatoprotective activity
OT  - Lipid peroxidation
OT  - Mountain ginseng
EDAT- 2014/12/03 06:00
MHDA- 2015/09/26 06:00
CRDT- 2014/12/03 06:00
PHST- 2014/07/08 00:00 [received]
PHST- 2014/09/21 00:00 [revised]
PHST- 2014/10/17 00:00 [accepted]
PHST- 2014/12/03 06:00 [entrez]
PHST- 2014/12/03 06:00 [pubmed]
PHST- 2015/09/26 06:00 [medline]
AID - S0378-8741(14)00757-0 [pii]
AID - 10.1016/j.jep.2014.10.047 [doi]
PST - ppublish
SO  - J Ethnopharmacol. 2014 Dec 2;158 Pt A:442-6. doi: 10.1016/j.jep.2014.10.047. Epub 
      2014 Oct 31.