PMID- 2544678 OWN - NLM STAT- MEDLINE DCOM- 19890810 LR - 20190828 IS - 0146-6615 (Print) IS - 0146-6615 (Linking) VI - 28 IP - 2 DP - 1989 Jun TI - Brief report: primary human herpesvirus 6 infection in a patient following liver transplantation from a seropositive donor. PG - 69-72 AB - A virus, isolated from peripheral blood lymphocytes of a patient 23 days after liver transplantation, was identified by negative contrast and thin-section electron microscopy, DNA hybridisation, and immunofluorescence as human herpesvirus 6 (HHV-6). The patient was seronegative for antibodies to HHV-6 before receiving the liver from a seropositive donor. Seroconversion for IgM and IgG antibodies occurred at the same time as the viraemia, indicating a primary response to HHV-6 infection that was probably acquired from the donor liver. The relationship of the infection to the patient's subsequent disease episodes is discussed. FAU - Ward, K N AU - Ward KN AD - Department of Pathology, University of Cambridge, England. FAU - Gray, J J AU - Gray JJ FAU - Efstathiou, S AU - Efstathiou S LA - eng PT - Case Reports PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - United States TA - J Med Virol JT - Journal of medical virology JID - 7705876 RN - 0 (Antibodies, Viral) RN - 0 (DNA Probes) SB - IM MH - Adult MH - Antibodies, Viral/biosynthesis MH - DNA Probes MH - Female MH - Fluorescent Antibody Technique MH - Herpesviridae/immunology/isolation & purification/ultrastructure MH - Herpesviridae Infections/*etiology/immunology/microbiology MH - Humans MH - Liver/immunology/microbiology MH - *Liver Transplantation MH - Postoperative Complications/*etiology/microbiology MH - Serologic Tests EDAT- 1989/06/01 00:00 MHDA- 1989/06/01 00:01 CRDT- 1989/06/01 00:00 PHST- 1989/06/01 00:00 [pubmed] PHST- 1989/06/01 00:01 [medline] PHST- 1989/06/01 00:00 [entrez] AID - 10.1002/jmv.1890280203 [doi] PST - ppublish SO - J Med Virol. 1989 Jun;28(2):69-72. doi: 10.1002/jmv.1890280203.