PMID- 25446810
OWN - NLM
STAT- MEDLINE
DCOM- 20151215
LR  - 20220318
IS  - 1872-7549 (Electronic)
IS  - 0166-4328 (Linking)
VI  - 278
DP  - 2015 Feb 1
TI  - The effects of Ginkgo biloba extract on cognitive functions in aged female rats: 
      the role of oxidative stress and brain-derived neurotrophic factor.
PG  - 453-61
LID - S0166-4328(14)00697-4 [pii]
LID - 10.1016/j.bbr.2014.10.032 [doi]
AB  - The aim of this study was to investigate the effects of Ginkgo biloba extract 
      (GBE) on cognitive functions as well as oxidative stress and brain-derived 
      neurotrophic factor (BDNF) levels in aged female rats. Rats were divided into 4 
      groups according to age (young vs. aged) and treatment (GBE vs. vehicle). GBE or 
      vehicle was given for 30 d, and a series of behavioral tests were performed. 
      Following behavioral testing, blood samples and brain tissues were obtained for 
      analysis of BDNF, malondialdehyde (MDA), 8-hydroxy-2'-deoxyguanosine (8-OHdG), 
      and glutathione levels, and superoxide dismutase activity. Locomotor activity and 
      anxiety levels were lower in the aged rats. Based on Morris water maze probe 
      trial findings, GBE supplementation increased the number of platform crossings in 
      the aged rats. MDA and 8-OHdG levels were lower in the brain tissue, and BDNF 
      levels were higher in plasma in the rates treated with GBE. Based on these 
      findings, we concluded that GBE supplementation improved cognitive functions by 
      decreasing oxidative damage and increasing the BDNF level in aged female rats.
CI  - Copyright (c) 2014 Elsevier B.V. All rights reserved.
FAU - Belviranli, Muaz
AU  - Belviranli M
AD  - Selcuk University, School of Medicine, Department of Physiology, Konya, Turkey. 
      Electronic address: mbelviranli@yahoo.com.
FAU - Okudan, Nilsel
AU  - Okudan N
AD  - Selcuk University, School of Medicine, Department of Physiology, Konya, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20141030
PL  - Netherlands
TA  - Behav Brain Res
JT  - Behavioural brain research
JID - 8004872
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Plant Extracts)
RN  - 4Y8F71G49Q (Malondialdehyde)
RN  - 88847-89-6 (8-Hydroxy-2'-Deoxyguanosine)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
RN  - G9481N71RO (Deoxyguanosine)
RN  - GAN16C9B8O (Glutathione)
SB  - IM
MH  - 8-Hydroxy-2'-Deoxyguanosine
MH  - Aging/*drug effects
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Cognition/*drug effects
MH  - Deoxyguanosine/analogs & derivatives/blood
MH  - Exploratory Behavior/drug effects
MH  - Female
MH  - Ginkgo biloba/*chemistry
MH  - Glutathione/blood
MH  - Malondialdehyde/blood
MH  - Maze Learning/drug effects
MH  - Oxidative Stress/*physiology
MH  - Plant Extracts/*pharmacology
MH  - Rats
MH  - Rats, Wistar
MH  - Statistics, Nonparametric
MH  - Superoxide Dismutase/blood
MH  - Time Factors
OTO - NOTNLM
OT  - Aging
OT  - BDNF
OT  - Cognitive function
OT  - Ginkgo biloba
OT  - Memory
OT  - Oxidative stress
EDAT- 2014/12/03 06:00
MHDA- 2015/12/17 06:00
CRDT- 2014/12/03 06:00
PHST- 2014/08/13 00:00 [received]
PHST- 2014/10/20 00:00 [revised]
PHST- 2014/10/21 00:00 [accepted]
PHST- 2014/12/03 06:00 [entrez]
PHST- 2014/12/03 06:00 [pubmed]
PHST- 2015/12/17 06:00 [medline]
AID - S0166-4328(14)00697-4 [pii]
AID - 10.1016/j.bbr.2014.10.032 [doi]
PST - ppublish
SO  - Behav Brain Res. 2015 Feb 1;278:453-61. doi: 10.1016/j.bbr.2014.10.032. Epub 2014 
      Oct 30.