PMID- 25447108
OWN - NLM
STAT- MEDLINE
DCOM- 20150227
LR  - 20141227
IS  - 1879-1891 (Electronic)
IS  - 0002-9394 (Linking)
VI  - 159
IP  - 2
DP  - 2015 Feb
TI  - Circadian macular volume changes in the healthy human choroid.
PG  - 365-71.e2
LID - S0002-9394(14)00702-8 [pii]
LID - 10.1016/j.ajo.2014.11.002 [doi]
AB  - PURPOSE: To investigate a potential circadian fluctuation of the choroidal volume 
      in healthy adults by enhanced depth imaging (EDI) via spectral-domain optical 
      coherence tomography (SD OCT). DESIGN: Prospective observational case series. 
      METHODS: Thirty healthy eyes of 15 healthy subjects with a median age of 26 years 
      (range 22-55) underwent EDI SD OCT scans for macular choroidal volume measurement 
      every 3 hours within a 24-hour period at a single tertiary center. The mean 
      ocular perfusion pressure was calculated for each eye at each of the 8 time 
      points as 2/3(mean arterial pressure-intraocular pressure [IOP]). The circadian 
      fluctuation of the macular choroidal volume as well as the association with axial 
      length, mean ocular perfusion pressure, or IOP was assessed using a linear mixed 
      model. RESULTS: Macular choroidal volume showed a significant circadian 
      fluctuation (P < .05) and was lowest at midday (mean +/- SD, 10.14 +/- 2.62 mm(3)) 
      and highest at 3 AM (mean +/- SD, 10.66 +/- 2.70 mm(3)). Of all factors tested, only 
      mean ocular perfusion pressure showed a significant association with macular 
      choroidal volume fluctuation (P = .016). CONCLUSIONS: Macular choroidal volume 
      shows a significant circadian pattern with higher values at night and lower 
      values during the day in young adults. Besides time, mean ocular perfusion 
      pressure is significantly associated with this fluctuation.
CI  - Copyright (c) 2015 Elsevier Inc. All rights reserved.
FAU - Seidel, Gerald
AU  - Seidel G
AD  - Department of Ophthalmology, Medical University of Graz/Austria, Graz, Austria. 
      Electronic address: gerald.seidel@medunigraz.at.
FAU - Hausberger, Silke
AU  - Hausberger S
AD  - Department of Ophthalmology, Medical University of Graz/Austria, Graz, Austria.
FAU - Herzog, Sereina Annik
AU  - Herzog SA
AD  - Institute for Medical Informatics, Statistics and Documentation, Medical 
      University of Graz/Austria, Graz, Austria.
FAU - Palkovits, Stefan
AU  - Palkovits S
AD  - Department of Ophthalmology, Medical University of Graz/Austria, Graz, Austria.
FAU - Poschl, Eva Maria
AU  - Poschl EM
AD  - Department of Ophthalmology, Medical University of Graz/Austria, Graz, Austria.
FAU - Wackernagel, Werner
AU  - Wackernagel W
AD  - Department of Ophthalmology, Medical University of Graz/Austria, Graz, Austria.
FAU - Weger, Martin
AU  - Weger M
AD  - Department of Ophthalmology, Medical University of Graz/Austria, Graz, Austria.
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20141106
PL  - United States
TA  - Am J Ophthalmol
JT  - American journal of ophthalmology
JID - 0370500
SB  - IM
MH  - Adult
MH  - Arterial Pressure/physiology
MH  - Axial Length, Eye/anatomy & histology
MH  - Choroid/*anatomy & histology
MH  - Circadian Rhythm/*physiology
MH  - Female
MH  - Healthy Volunteers
MH  - Humans
MH  - Intraocular Pressure/physiology
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Tomography, Optical Coherence
MH  - Visual Acuity/physiology
MH  - Young Adult
EDAT- 2014/12/03 06:00
MHDA- 2015/02/28 06:00
CRDT- 2014/12/03 06:00
PHST- 2014/06/29 00:00 [received]
PHST- 2014/10/31 00:00 [revised]
PHST- 2014/11/04 00:00 [accepted]
PHST- 2014/12/03 06:00 [entrez]
PHST- 2014/12/03 06:00 [pubmed]
PHST- 2015/02/28 06:00 [medline]
AID - S0002-9394(14)00702-8 [pii]
AID - 10.1016/j.ajo.2014.11.002 [doi]
PST - ppublish
SO  - Am J Ophthalmol. 2015 Feb;159(2):365-71.e2. doi: 10.1016/j.ajo.2014.11.002. Epub 
      2014 Nov 6.