PMID- 25448796
OWN - NLM
STAT- MEDLINE
DCOM- 20161215
LR  - 20161230
IS  - 2174-2030 (Electronic)
IS  - 0870-2551 (Linking)
VI  - 33
IP  - 11
DP  - 2014 Nov
TI  - High levels of high-sensitivity C-reactive protein and uric acid can predict 
      disease severity in patients with mitral regurgitation.
PG  - 699-706
LID - S0870-2551(14)00255-8 [pii]
LID - 10.1016/j.repc.2014.03.014 [doi]
AB  - INTRODUCTION: Both high-sensitivity CRP (hs-CRP) and uric acid (UA) levels are 
      known to be increased in heart failure patients and are associated with poorer 
      functional capacity and adverse outcome. The role of these markers in patients 
      with mitral regurgitation (MR) is less clear. The aim of this study was to assess 
      the relationship between hs-CRP, UA and organic MR. We also assessed whether 
      hs-CRP and UA levels are correlated with symptoms of MR, severity of MR, LV 
      remodeling and outcome during follow-up. METHODS: A total of 200 consecutive 
      patients (87 men [43.5%]; mean age 61.6+/-12.5 years) with moderate or severe 
      isolated and organic MR were included in the study. All the patients were 
      assessed clinically and were managed and treated with standard medical therapy 
      according to evidence-based practice guidelines. Patients were categorized 
      according to New York Heart Association (NYHA) functional class. We assessed and 
      graded the severity of MR using a multiparametric approach. hs-CRP was measured 
      with chemiluminescent immunometric assay using an IMMULITE(R) 1000 autoanalyzer 
      (Siemens, Germany). Serum UA levels were analyzed using a Cobas(R) 6000 
      autoanalyzer (Roche Diagnostics, Mannheim, Germany). RESULTS: Mean UA levels 
      increased significantly with NYHA class: 4.46+/-1.58 mg/dl for patients in NYHA 
      class I, 5.91+/-1.69 mg/dl for class II, 6.31+/-2.16 mg/dl for class III and 
      8.86+/-3.17 mg/dl for class IV (p<0.001). Mean UA levels also increased 
      significantly with increased severity of MR (moderate 5.62+/-1.9 mg/dl, moderate to 
      severe 5.56+/-1.2 mg/dl, severe 7.38+/-3.4 mg/dl, p<0.001). There was a significant 
      correlation between UA level and left ventricular end-diastolic diameter (r=0.40; 
      p<0.001), left ventricular end-systolic diameter (r=0.297; p=0.001) and left 
      ventricular ejection fraction (LVEF) (r=0.195, p=0.036), whereas hs-CRP was not 
      correlated with these parameters. In multivariate Cox proportional hazards 
      analysis LVEF, NYHA class and UA levels were the only independent predictors of 
      death. CONCLUSION: UA and hs-CRP levels can help identify patients with 
      asymptomatic moderate or severe mitral regurgitation. UA levels may be useful to 
      assess the extent of left ventricular remodeling and in the optimal timing of 
      mitral valve surgery in certain subsets of patients.
CI  - Copyright (c) 2013 Sociedade Portuguesa de Cardiologia. Published by Elsevier 
      Espana. All rights reserved.
FAU - Turker, Yasin
AU  - Turker Y
AD  - Department of Cardiology, Duzce University Faculty of Medicine, Duzce, Turkey. 
      Electronic address: dryasinturker@hotmail.com.
FAU - Ekinozu, Ismail
AU  - Ekinozu I
AD  - Department of Cardiology, Duzce University Faculty of Medicine, Duzce, Turkey.
FAU - Turker, Yasemin
AU  - Turker Y
AD  - Family Medicine Center, Duzce, Turkey.
FAU - Akkaya, Mehmet
AU  - Akkaya M
AD  - Department of Cardiology, BezmiAlem University Hospital, Istanbul, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20141111
PL  - Portugal
TA  - Rev Port Cardiol
JT  - Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de 
      Cardiologia = Portuguese journal of cardiology : an official journal of the 
      Portuguese Society of Cardiology
JID - 8710716
RN  - 268B43MJ25 (Uric Acid)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Aged
MH  - C-Reactive Protein/*analysis
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Mitral Valve Insufficiency/*blood/*diagnosis
MH  - Predictive Value of Tests
MH  - Prospective Studies
MH  - Uric Acid/*blood
OTO - NOTNLM
OT  - Classe da NYHA
OT  - High-sensitivity C-reactive protein
OT  - Mitral regurgitation
OT  - NYHA class
OT  - Proteina C-reativa de alta sensibilidade
OT  - Regurgitacao mitral
OT  - Uric acid
OT  - Acido urico
EDAT- 2014/12/03 06:00
MHDA- 2016/12/16 06:00
CRDT- 2014/12/03 06:00
PHST- 2013/07/29 00:00 [received]
PHST- 2014/02/10 00:00 [revised]
PHST- 2014/03/31 00:00 [accepted]
PHST- 2014/12/03 06:00 [entrez]
PHST- 2014/12/03 06:00 [pubmed]
PHST- 2016/12/16 06:00 [medline]
AID - S0870-2551(14)00255-8 [pii]
AID - 10.1016/j.repc.2014.03.014 [doi]
PST - ppublish
SO  - Rev Port Cardiol. 2014 Nov;33(11):699-706. doi: 10.1016/j.repc.2014.03.014. Epub 
      2014 Nov 11.