PMID- 25449400
OWN - NLM
STAT- MEDLINE
DCOM- 20150831
LR  - 20141222
IS  - 1873-507X (Electronic)
IS  - 0031-9384 (Linking)
VI  - 139
DP  - 2015 Feb
TI  - Antidepressant-like effect of n-3 PUFAs in CUMS rats: role of tPA/PAI-1 system.
PG  - 210-5
LID - S0031-9384(14)00572-1 [pii]
LID - 10.1016/j.physbeh.2014.11.054 [doi]
AB  - BDNF is strongly implicated in the development of depression. Recent evidence has 
      indicated that tissue plasminogen activator (tPA) and plasminogen activator 
      inhibitor-1 (PAI-1) are related to the cleavage of pro-brain-derived neurotrophic 
      factor (BDNF) into its mature form. Chronic unpredicted mild stress (CUMS) is 
      widely used to induce depressive behaviors in rodents. Therefore, we investigated 
      the effects of PUFAs and sertraline on tPA/PAI-1 system in CUMS rats. After 5 
      weeks of CUMS procedures, the rats were induced to a depressive-like state. The 
      expressions of PAI-1 and proBDNF were increased in the prefrontal cortex and 
      hippocampus of CUMS rats. N-3 polyunsaturated fatty acids (PUFAs) or sertraline 
      administration reversed the changes in behavioral test and induced the expression 
      of tPA in certain brain areas, but failed to restore the CUMS-induced PAI-1 
      expression. Meanwhile, the antidepressant treatment also accelerated the 
      extracellular conversion of proBDNF into mature BDNF in CUMS rats. Our results 
      firstly showed the synchronously altered balance of tPA/PAI-1 system in the 
      prefrontal cortex and hippocampus of CUMS rats, which was partly ameliorated by 
      PUFAs and sertraline medication, providing new evidence for the involvement of 
      tPA/PAI-1 system in the progression and treatment of depression.
CI  - Copyright (c) 2014 Elsevier Inc. All rights reserved.
FAU - Tang, Mimi
AU  - Tang M
AD  - Institute of Clinical Pharmacy & Pharmacology, Second Xiangya Hospital, Central 
      South University, Changsha, Hunan, China; School of Pharmaceutical Sciences, 
      Central South University, Changsha, China.
FAU - Jiang, Pei
AU  - Jiang P
AD  - Institute of Clinical Pharmacy & Pharmacology, Second Xiangya Hospital, Central 
      South University, Changsha, Hunan, China; School of Pharmaceutical Sciences, 
      Central South University, Changsha, China.
FAU - Li, Huande
AU  - Li H
AD  - Institute of Clinical Pharmacy & Pharmacology, Second Xiangya Hospital, Central 
      South University, Changsha, Hunan, China. Electronic address: 
      lihuande1953@126.com.
FAU - Cai, Hualin
AU  - Cai H
AD  - Institute of Clinical Pharmacy & Pharmacology, Second Xiangya Hospital, Central 
      South University, Changsha, Hunan, China.
FAU - Liu, Yiping
AU  - Liu Y
AD  - Institute of Clinical Pharmacy & Pharmacology, Second Xiangya Hospital, Central 
      South University, Changsha, Hunan, China.
FAU - Gong, Hui
AU  - Gong H
AD  - Institute of Clinical Pharmacy & Pharmacology, Second Xiangya Hospital, Central 
      South University, Changsha, Hunan, China.
FAU - Zhang, Lihong
AU  - Zhang L
AD  - Institute of Clinical Pharmacy & Pharmacology, Second Xiangya Hospital, Central 
      South University, Changsha, Hunan, China; School of Pharmaceutical Sciences, 
      Central South University, Changsha, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141121
PL  - United States
TA  - Physiol Behav
JT  - Physiology & behavior
JID - 0151504
RN  - 0 (Antidepressive Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Fatty Acids, Omega-3)
RN  - 0 (Plasminogen Activator Inhibitor 1)
RN  - EC 3.4.21.68 (Tissue Plasminogen Activator)
RN  - QUC7NX6WMB (Sertraline)
SB  - IM
MH  - Animals
MH  - Antidepressive Agents/*pharmacology
MH  - Body Weight
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Chronic Disease
MH  - Depressive Disorder/*drug therapy/physiopathology
MH  - Disease Models, Animal
MH  - Fatty Acids, Omega-3/*pharmacology
MH  - Hippocampus/drug effects/physiopathology
MH  - Plasminogen Activator Inhibitor 1/*metabolism
MH  - Prefrontal Cortex/drug effects/physiopathology
MH  - Random Allocation
MH  - Rats, Sprague-Dawley
MH  - Sertraline/*pharmacology
MH  - Stress, Psychological/physiopathology
MH  - Tissue Plasminogen Activator/*metabolism
OTO - NOTNLM
OT  - Brain-derived neurotrophic factor
OT  - Chronic unpredicted mild stress
OT  - Plasminogen activator inhibitor-1
OT  - Polyunsaturated fatty acids
OT  - Sertraline
OT  - Tissue plasminogen activator
EDAT- 2014/12/03 06:00
MHDA- 2015/09/01 06:00
CRDT- 2014/12/03 06:00
PHST- 2014/09/24 00:00 [received]
PHST- 2014/11/14 00:00 [revised]
PHST- 2014/11/15 00:00 [accepted]
PHST- 2014/12/03 06:00 [entrez]
PHST- 2014/12/03 06:00 [pubmed]
PHST- 2015/09/01 06:00 [medline]
AID - S0031-9384(14)00572-1 [pii]
AID - 10.1016/j.physbeh.2014.11.054 [doi]
PST - ppublish
SO  - Physiol Behav. 2015 Feb;139:210-5. doi: 10.1016/j.physbeh.2014.11.054. Epub 2014 
      Nov 21.