PMID- 25449634
OWN - NLM
STAT- MEDLINE
DCOM- 20150224
LR  - 20190110
IS  - 1879-3185 (Electronic)
IS  - 0300-483X (Linking)
VI  - 327
DP  - 2015 Jan 2
TI  - Developmental exposure to purity-controlled polychlorinated biphenyl congeners 
      (PCB74 and PCB95) in rats: effects on brainstem auditory evoked potentials and 
      catalepsy.
PG  - 22-31
LID - S0300-483X(14)00216-9 [pii]
LID - 10.1016/j.tox.2014.11.004 [doi]
AB  - Whereas the effects of dioxin-like polychlorinated biphenyls (DL-PCBs) are well 
      described, less is known about non-dioxin-like PCBs (NDL-PCBs), including 
      influences on the nervous system and related behavioral effects after 
      developmental exposure. Following the examination of the highly purified NDL 
      congeners PCB52 and PCB180, we report here the results of experiments with PCB74 
      and PCB95. Rat dams were orally exposed to equimolar doses of either congener 
      (40mumol/kg bw - 11.68mg PCB74/kg bw or 13.06mg PCB95/kg bw) from gestational day 
      (GD) 10 to postnatal day (PND) 7. Control dams were given the vehicle. Adult 
      offspring were tested for cataleptic behavior after induction with haloperidol, a 
      classical neuroleptic drug, and brainstem auditory evoked potentials (BAEPs), 
      using clicks and tone pips of different frequencies for stimulation. Results 
      revealed slight effects on latencies to movement onset in female offspring 
      exposed to PCB74, whereas PCB74 males and offspring exposed to PCB95 were not 
      affected. Pronounced changes were observed in BAEPs at low frequencies in PCB74 
      offspring, with elevated thresholds in both sexes. PCB95 increased thresholds in 
      males, but not females. Small effects were detected on latency of the late wave 
      IV in both sexes after developmental exposure to PCB74 or PCB95. Compared with 
      the other NDL-PCB congeners tested, PCB74 caused the most pronounced effects on 
      BAEPs.
CI  - Copyright (c) 2014 Elsevier Ireland Ltd. All rights reserved.
FAU - Lilienthal, Hellmuth
AU  - Lilienthal H
AD  - Center of Toxicology, IPA - Institute for Prevention and Occupational Medicine, 
      German Social Accident Insurance, Ruhr University of Bochum, Buerkle de la Camp 
      Platz 1, 44789 Bochum, Germany. Electronic address: lilienthal@ipa.rub.de.
FAU - Korkalainen, Merja
AU  - Korkalainen M
AD  - Department of Environmental Health, THL - National Institute for Health and 
      Welfare, 70701 Kuopio, Finland; Department of Environmental Science, University 
      of Eastern Finland, 70211 Kuopio, Finland. Electronic address: 
      merja.korkalainen@thl.fi.
FAU - Andersson, Patrik L
AU  - Andersson PL
AD  - Department of Chemistry, Umea University, 901 87 Umea, Sweden. Electronic 
      address: patrik.andersson@chem.umu.se.
FAU - Viluksela, Matti
AU  - Viluksela M
AD  - Department of Environmental Health, THL - National Institute for Health and 
      Welfare, 70701 Kuopio, Finland; Department of Environmental Science, University 
      of Eastern Finland, 70211 Kuopio, Finland. Electronic address: 
      matti.viluksela@thl.fi.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141113
PL  - Ireland
TA  - Toxicology
JT  - Toxicology
JID - 0361055
RN  - 0YO8J06WCR (2,2',3,5',6-pentachlorobiphenyl)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
RN  - J6292F8L3D (Haloperidol)
RN  - W0250484DW (2,4,4',5-tetrachlorobiphenyl)
SB  - IM
MH  - Animals
MH  - Brain Stem/*drug effects/physiology
MH  - Catalepsy/*chemically induced
MH  - Evoked Potentials, Auditory/*drug effects
MH  - Female
MH  - Haloperidol/administration & dosage
MH  - Male
MH  - Polychlorinated Biphenyls/*toxicity
MH  - Pregnancy
MH  - *Prenatal Exposure Delayed Effects
MH  - Rats
MH  - Rats, Long-Evans
OTO - NOTNLM
OT  - Auditory development
OT  - Behavior
OT  - Catalepsy
OT  - Dopamine
OT  - Polychlorinated biphenyls
OT  - Rats
EDAT- 2014/12/03 06:00
MHDA- 2015/02/25 06:00
CRDT- 2014/12/03 06:00
PHST- 2014/08/29 00:00 [received]
PHST- 2014/11/11 00:00 [revised]
PHST- 2014/11/11 00:00 [accepted]
PHST- 2014/12/03 06:00 [entrez]
PHST- 2014/12/03 06:00 [pubmed]
PHST- 2015/02/25 06:00 [medline]
AID - S0300-483X(14)00216-9 [pii]
AID - 10.1016/j.tox.2014.11.004 [doi]
PST - ppublish
SO  - Toxicology. 2015 Jan 2;327:22-31. doi: 10.1016/j.tox.2014.11.004. Epub 2014 Nov 
      13.