PMID- 25449681
OWN - NLM
STAT- MEDLINE
DCOM- 20150518
LR  - 20181202
IS  - 1873-0183 (Electronic)
IS  - 1568-9972 (Linking)
VI  - 14
IP  - 2
DP  - 2015 Feb
TI  - Role of dendritic cells in the initiation, progress and modulation of systemic 
      autoimmune diseases.
PG  - 127-39
LID - S1568-9972(14)00222-5 [pii]
LID - 10.1016/j.autrev.2014.10.010 [doi]
AB  - Dendritic cells (DCs) play a key role in the activation of the immune response 
      against pathogens, as well as in the modulation of peripheral tolerance to 
      self-antigens (Ags). Furthermore, an imbalance in the activating/inhibitory 
      receptors expressed on the surface of DCs has been linked to increased 
      susceptibility to develop autoimmune diseases underscoring their immunogenicity 
      potential. It has been described that modulation of activating or inhibitory 
      molecules expressed by DCs, such as CD86, TLRs, PDL-1 and FcgammaRs, can define the 
      immunogenic phenotype. On the other hand, T cell tolerance can be achieved by 
      tolerogenic DCs, which have the capacity of blocking undesired autoimmune 
      responses in several experimental models, mainly by inducing T cell anergy, 
      expansion of regulatory T cells and limiting B cell responses. Due to the lack of 
      specific therapies to treat autoimmune disorders and the tolerogenic capacity of 
      DCs shown in experimental autoimmune disease models, autologous tolDCs are a 
      potential therapeutic strategy for fine-tuning the immune system and 
      reestablishing tolerance in human autoimmune diseases. New advances in the role 
      of DCs in systemic lupus erythematosus (SLE) pathogenesis and the identification 
      of pathogenic self-Ags may favor the development of novel tolDC based therapies 
      with a major clinical impact. In this review, we discuss recent data relative to 
      the role of DCs in systemic autoimmune pathogenesis and their use as a therapy to 
      restore tolerance.
CI  - Copyright (c) 2014 Elsevier B.V. All rights reserved.
FAU - Mackern-Oberti, Juan Pablo
AU  - Mackern-Oberti JP
AD  - Millennium Institute on Immunology and Immunotherapy, Departamento de Genetica 
      Molecular y Microbiologia, Facultad de Ciencias Biologicas, Pontificia 
      Universidad Catolica de Chile, Chile.
FAU - Llanos, Carolina
AU  - Llanos C
AD  - Millennium Institute on Immunology and Immunotherapy, Departamento de Inmunologia 
      Clinica y Reumatologia, Escuela de Medicina, Pontificia Universidad Catolica de 
      Chile, Chile.
FAU - Vega, Fabian
AU  - Vega F
AD  - Millennium Institute on Immunology and Immunotherapy, Departamento de Inmunologia 
      Clinica y Reumatologia, Escuela de Medicina, Pontificia Universidad Catolica de 
      Chile, Chile.
FAU - Salazar-Onfray, Flavio
AU  - Salazar-Onfray F
AD  - Millennium Institute on Immunology and Immunotherapy, Instituto de Ciencias 
      Biomedicas, Facultad de Medicina, Universidad de Chile, Santiago 8380453, Chile.
FAU - Riedel, Claudia A
AU  - Riedel CA
AD  - Millennium Institute on Immunology and Immunotherapy, Departamento de Ciencias 
      Biologicas, Facultad de Ciencias Biologicas y Facultad de Medicina, Universidad 
      Andres Bello, Santiago, Chile; INSERM U1064, Nantes, France.
FAU - Bueno, Susan M
AU  - Bueno SM
AD  - Millennium Institute on Immunology and Immunotherapy, Departamento de Genetica 
      Molecular y Microbiologia, Facultad de Ciencias Biologicas, Pontificia 
      Universidad Catolica de Chile, Chile; INSERM U1064, Nantes, France.
FAU - Kalergis, Alexis M
AU  - Kalergis AM
AD  - Millennium Institute on Immunology and Immunotherapy, Departamento de Genetica 
      Molecular y Microbiologia, Facultad de Ciencias Biologicas, Pontificia 
      Universidad Catolica de Chile, Chile; Millennium Institute on Immunology and 
      Immunotherapy, Departamento de Inmunologia Clinica y Reumatologia, Escuela de 
      Medicina, Pontificia Universidad Catolica de Chile, Chile; INSERM U1064, Nantes, 
      France. Electronic address: akalergis@bio.puc.cl.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20141014
PL  - Netherlands
TA  - Autoimmun Rev
JT  - Autoimmunity reviews
JID - 101128967
RN  - 0 (Autoantigens)
RN  - 0 (Toll-Like Receptors)
SB  - IM
MH  - Animals
MH  - Autoantigens/immunology
MH  - Autoimmune Diseases/*immunology
MH  - B-Lymphocytes/immunology
MH  - Dendritic Cells/*immunology
MH  - Humans
MH  - Immune Tolerance/immunology
MH  - Toll-Like Receptors/immunology
OTO - NOTNLM
OT  - Dendritic cells
OT  - Immune tolerance
OT  - Immunotherapy
OT  - Lupus
OT  - Systemic autoimmunity
EDAT- 2014/12/03 06:00
MHDA- 2015/05/20 06:00
CRDT- 2014/12/03 06:00
PHST- 2014/09/19 00:00 [received]
PHST- 2014/09/30 00:00 [accepted]
PHST- 2014/12/03 06:00 [entrez]
PHST- 2014/12/03 06:00 [pubmed]
PHST- 2015/05/20 06:00 [medline]
AID - S1568-9972(14)00222-5 [pii]
AID - 10.1016/j.autrev.2014.10.010 [doi]
PST - ppublish
SO  - Autoimmun Rev. 2015 Feb;14(2):127-39. doi: 10.1016/j.autrev.2014.10.010. Epub 
      2014 Oct 14.