PMID- 25449839
OWN - NLM
STAT- MEDLINE
DCOM- 20150820
LR  - 20220408
IS  - 1872-7549 (Electronic)
IS  - 0166-4328 (Print)
IS  - 0166-4328 (Linking)
VI  - 279
DP  - 2015 Feb 15
TI  - Multiple faces of BDNF in cocaine addiction.
PG  - 240-54
LID - S0166-4328(14)00747-5 [pii]
LID - 10.1016/j.bbr.2014.11.018 [doi]
AB  - Brain-derived neurotrophic factor (BDNF) has been found to play roles in many 
      types of plasticity including drug addiction. Here, we focus on rodent studies 
      over the past two decades that have demonstrated diverse roles of BDNF in models 
      of cocaine addiction. First, we will provide an overview of studies showing that 
      cocaine exposure alters (and generally increases) BDNF levels in reward-related 
      regions including the ventral tegmental area, nucleus accumbens, prefrontal 
      cortex, and amygdala. Then we will review evidence that BDNF contributes to 
      behavioral changes in animal models of cocaine addiction, focusing on conditioned 
      place preference, behavioral sensitization, maintenance and reinstatement of 
      self-administration, and incubation of cocaine craving. Last, we will review the 
      role of BDNF in synaptic plasticity, particularly as it relates to plasticity of 
      AMPA receptor transmission after cocaine exposure. We conclude that BDNF 
      regulates cocaine-induced behaviors in a highly complex manner that varies 
      depending on the brain region (and even among different cell types within the 
      same brain region), the nature of cocaine exposure, and the "addiction phase" 
      examined (e.g., acquisition vs maintenance; early vs late withdrawal). These 
      complexities make BDNF a daunting therapeutic target for treating cocaine 
      addiction. However, recent clinical evidence suggests that the serum BDNF level 
      may serve as a biomarker in cocaine addicts to predict future relapse, providing 
      an alternative direction for exploring BDNF's potential relevance to treating 
      cocaine addiction.
CI  - Copyright (c) 2014 Elsevier B.V. All rights reserved.
FAU - Li, Xuan
AU  - Li X
AD  - Behavioral Neuroscience Research Branch, Intramural Research Program, 
      NIDA/NIH/DHHS, Baltimore, MD, USA. Electronic address: anna.li@nih.gov.
FAU - Wolf, Marina E
AU  - Wolf ME
AD  - Department of Neuroscience, Rosalind Franklin University of Medicine and Science, 
      North Chicago, IL, USA.
LA  - eng
GR  - R01 DA009621/DA/NIDA NIH HHS/United States
GR  - K05 DA029099/DA/NIDA NIH HHS/United States
GR  - R01 DA015835/DA/NIDA NIH HHS/United States
GR  - DA009621/DA/NIDA NIH HHS/United States
GR  - DA015835/DA/NIDA NIH HHS/United States
GR  - R37 DA015835/DA/NIDA NIH HHS/United States
GR  - DA029099/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
DEP - 20141115
PL  - Netherlands
TA  - Behav Brain Res
JT  - Behavioural brain research
JID - 8004872
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Receptors, AMPA)
RN  - I5Y540LHVR (Cocaine)
SB  - IM
MH  - Animals
MH  - Brain/drug effects/*metabolism
MH  - Brain-Derived Neurotrophic Factor/*metabolism/*physiology
MH  - Cocaine/administration & dosage
MH  - Cocaine-Related Disorders/*metabolism
MH  - Conditioning, Psychological/drug effects/physiology
MH  - Corpus Striatum/drug effects/metabolism
MH  - Craving/drug effects/physiology
MH  - Disease Models, Animal
MH  - Mice
MH  - Neuronal Plasticity/drug effects
MH  - Rats
MH  - Receptors, AMPA/metabolism
MH  - Reward
MH  - Self Administration
PMC - PMC4277902
MID - NIHMS642907
OTO - NOTNLM
OT  - AMPA receptor.
OT  - BDNF
OT  - Cocaine addiction
OT  - TrkB
COIS- Conflict of interest: The authors report no biomedical financial interests or 
      potential conflicts of interest.
EDAT- 2014/12/03 06:00
MHDA- 2015/08/21 06:00
PMCR- 2016/02/15
CRDT- 2014/12/03 06:00
PHST- 2014/09/04 00:00 [received]
PHST- 2014/11/04 00:00 [revised]
PHST- 2014/11/08 00:00 [accepted]
PHST- 2014/12/03 06:00 [entrez]
PHST- 2014/12/03 06:00 [pubmed]
PHST- 2015/08/21 06:00 [medline]
PHST- 2016/02/15 00:00 [pmc-release]
AID - S0166-4328(14)00747-5 [pii]
AID - 10.1016/j.bbr.2014.11.018 [doi]
PST - ppublish
SO  - Behav Brain Res. 2015 Feb 15;279:240-54. doi: 10.1016/j.bbr.2014.11.018. Epub 
      2014 Nov 15.