PMID- 25450363
OWN - NLM
STAT- MEDLINE
DCOM- 20150501
LR  - 20161125
IS  - 1090-2104 (Electronic)
IS  - 0006-291X (Linking)
VI  - 454
IP  - 1
DP  - 2014 Nov 7
TI  - Naringenin suppresses macrophage infiltration into adipose tissue in an early 
      phase of high-fat diet-induced obesity.
PG  - 95-101
LID - S0006-291X(14)01836-1 [pii]
LID - 10.1016/j.bbrc.2014.10.038 [doi]
AB  - Obese adipose tissue is characterized by increased macrophage infiltration, which 
      results in chronic inflammation in adipose tissue and leads to obesity-related 
      diseases such as type 2 diabetes mellitus and atherosclerosis. The regulation of 
      macrophage infiltration into adipose tissue is an important strategy for 
      preventing and treating obesity-related diseases. In this study, we report that 
      naringenin, a citrus flavonoid, suppressed macrophage infiltration into adipose 
      tissue induced by short-term (14 days) feeding of a high-fat diet in mice; 
      although naringenin did not show any differences in high-fat diet-induced changes 
      of serum biochemical parameters in this short administration period. Naringenin 
      suppressed monocyte chemoattractant protein-1 (MCP-1) in adipose tissue, and this 
      effect was mediated in part through inhibition of c-Jun NH2-terminal kinase 
      pathway. Naringenin also inhibited MCP-1 expression in adipocytes, macrophages, 
      and a co-culture of adipocytes and macrophages. Our results suggest a mechanism 
      by which daily consumption of naringenin may exhibit preventive effects on 
      obesity-related diseases.
CI  - Copyright (c) 2014 Elsevier Inc. All rights reserved.
FAU - Yoshida, Hiroki
AU  - Yoshida H
AD  - Department of Biochemistry, Graduate School of Clinical Pharmacy, Kyushu 
      University of Health and Welfare, 1714-1 Yoshino, Nobeoka, Miyazaki 882-8508, 
      Japan. Electronic address: h-yoshida@phoenix.ac.jp.
FAU - Watanabe, Hideaki
AU  - Watanabe H
AD  - Department of Biochemistry, Graduate School of Clinical Pharmacy, Kyushu 
      University of Health and Welfare, 1714-1 Yoshino, Nobeoka, Miyazaki 882-8508, 
      Japan.
FAU - Ishida, Akiko
AU  - Ishida A
AD  - Department of Biochemistry, Graduate School of Clinical Pharmacy, Kyushu 
      University of Health and Welfare, 1714-1 Yoshino, Nobeoka, Miyazaki 882-8508, 
      Japan.
FAU - Watanabe, Wataru
AU  - Watanabe W
AD  - Department of Microbiology, Graduate School of Clinical Pharmacy, Kyushu 
      University of Health and Welfare, 1714-1 Yoshino, Nobeoka, Miyazaki 882-8508, 
      Japan.
FAU - Narumi, Keiko
AU  - Narumi K
AD  - Department of Clinical Pharmacy, Graduate School of Clinical Pharmacy, Kyushu 
      University of Health and Welfare, 1714-1 Yoshino, Nobeoka, Miyazaki 882-8508, 
      Japan.
FAU - Atsumi, Toshiyuki
AU  - Atsumi T
AD  - Department of Pharmacognosy, Graduate School of Clinical Pharmacy, Kyushu 
      University of Health and Welfare, 1714-1 Yoshino, Nobeoka, Miyazaki 882-8508, 
      Japan.
FAU - Sugita, Chihiro
AU  - Sugita C
AD  - Department of Biochemistry, Graduate School of Clinical Pharmacy, Kyushu 
      University of Health and Welfare, 1714-1 Yoshino, Nobeoka, Miyazaki 882-8508, 
      Japan.
FAU - Kurokawa, Masahiko
AU  - Kurokawa M
AD  - Department of Biochemistry, Graduate School of Clinical Pharmacy, Kyushu 
      University of Health and Welfare, 1714-1 Yoshino, Nobeoka, Miyazaki 882-8508, 
      Japan. Electronic address: b2mk@phoenix.ac.jp.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141018
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (Anthracenes)
RN  - 0 (Ccl2 protein, mouse)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Flavanones)
RN  - 0 (RNA, Messenger)
RN  - 1TW30Y2766 (pyrazolanthrone)
RN  - HN5425SBF2 (naringenin)
SB  - IM
MH  - 3T3-L1 Cells
MH  - Adipocytes/drug effects/metabolism
MH  - Adipose Tissue/*drug effects/metabolism/*pathology
MH  - Animals
MH  - Anthracenes/pharmacology
MH  - Cell Line
MH  - Chemokine CCL2/biosynthesis/genetics
MH  - Diabetes Mellitus, Type 2/prevention & control
MH  - Diet, High-Fat/*adverse effects
MH  - Flavanones/administration & dosage/*pharmacology
MH  - MAP Kinase Signaling System/drug effects
MH  - Macrophages/*drug effects/*pathology
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Obesity/*drug therapy/etiology/*pathology
MH  - RNA, Messenger/genetics/metabolism
MH  - Time Factors
OTO - NOTNLM
OT  - Adipose tissue
OT  - MCP-1
OT  - Macrophage
OT  - Naringenin
EDAT- 2014/12/03 06:00
MHDA- 2015/05/02 06:00
CRDT- 2014/12/03 06:00
PHST- 2014/10/04 00:00 [received]
PHST- 2014/10/09 00:00 [accepted]
PHST- 2014/12/03 06:00 [entrez]
PHST- 2014/12/03 06:00 [pubmed]
PHST- 2015/05/02 06:00 [medline]
AID - S0006-291X(14)01836-1 [pii]
AID - 10.1016/j.bbrc.2014.10.038 [doi]
PST - ppublish
SO  - Biochem Biophys Res Commun. 2014 Nov 7;454(1):95-101. doi: 
      10.1016/j.bbrc.2014.10.038. Epub 2014 Oct 18.