PMID- 25450575
OWN - NLM
STAT- MEDLINE
DCOM- 20151229
LR  - 20220408
IS  - 1873-1686 (Electronic)
IS  - 0167-0115 (Linking)
VI  - 194-195
DP  - 2014 Nov
TI  - Prior regular exercise reverses the decreased effects of sleep deprivation on 
      brain-derived neurotrophic factor levels in the hippocampus of ovariectomized 
      female rats.
PG  - 11-5
LID - S0167-0115(14)00087-1 [pii]
LID - 10.1016/j.regpep.2014.11.004 [doi]
AB  - Previous studies indicated that brain-derived neurotrophic factor (BDNF) is the 
      main candidate to mediate the beneficial effects of exercise on cognitive 
      function in sleep deprived male rats. In addition, our previous findings 
      demonstrate that female rats are more vulnerable to the deleterious effects of 
      sleep deprivation on cognitive performance and synaptic plasticity. Therefore, 
      the current study was designed to investigate the effects of treadmill exercise 
      and/or sleep deprivation (SD) on the levels of BDNF mRNA and protein in the 
      hippocampus of female rats. Intact and ovariectomized (OVX) female Wistar rats 
      were used in the present experiment. The exercise protocol was four weeks 
      treadmill running and sleep deprivation was accomplished using the multiple 
      platform method. Quantitative reverse transcriptase-polymerase chain reaction 
      (RT-PCR) and immunoblot analysis were used to evaluate the level of BDNF mRNA and 
      protein in the rat hippocampus respectively. Our results showed that protein and 
      mRNA expression of BDNF was significantly (p<0.05) decreased after 72 h SD in OVX 
      rats in compared with other groups. Furthermore, sleep deprived OVX rats under 
      exercise conditions had a significant (p<0.05) up-regulation of the BDNF protein 
      and mRNA in the hippocampus. These findings suggest that regular exercise can 
      exert a protective effect against hippocampus-related functions and impairments 
      induced by sleep deprivation probably by inducing BDNF expression.
CI  - Copyright (c) 2014 Elsevier B.V. All rights reserved.
FAU - Saadati, Hakimeh
AU  - Saadati H
AD  - Neuroscience Research Center, Institute of Neuropharmacology, Kerman University 
      of Medical Sciences, Kerman, Iran. Electronic address: hsadat54@yahoo.com.
FAU - Sheibani, Vahid
AU  - Sheibani V
AD  - Neuroscience Research Center, Institute of Neuropharmacology, Kerman University 
      of Medical Sciences, Kerman, Iran; Department of Physiology, School of Medicine, 
      Kerman University of Medical Sciences, Kerman, Iran. Electronic address: 
      vsheibani2@yahoo.com.
FAU - Esmaeili-Mahani, Saeed
AU  - Esmaeili-Mahani S
AD  - Department of Biology, Faculty of Science, Shahid Bahonar University of Kerman, 
      Kerman, Iran. Electronic address: Semahani@yahoo.com.
FAU - Darvishzadeh-Mahani, Fatemeh
AU  - Darvishzadeh-Mahani F
AD  - Neuroscience Research Center, Institute of Neuropharmacology, Kerman University 
      of Medical Sciences, Kerman, Iran. Electronic address: 
      darvishzadeh-fatemeh@yahoo.com.
FAU - Mazhari, Shahrzad
AU  - Mazhari S
AD  - Neuroscience Research Center, Institute of Neuropharmacology, Kerman University 
      of Medical Sciences, Kerman, Iran. Electronic address: Shahrzadmz@yahoo.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141120
PL  - Netherlands
TA  - Regul Pept
JT  - Regulatory peptides
JID - 8100479
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/genetics/*metabolism
MH  - Female
MH  - Hippocampus/*metabolism
MH  - *Ovariectomy
MH  - Physical Conditioning, Animal/*physiology
MH  - RNA, Messenger/genetics/metabolism
MH  - Rats
MH  - Rats, Wistar
MH  - Sleep Deprivation/*physiopathology
OTO - NOTNLM
OT  - Brain derived neurotrophic factors
OT  - Female rat
OT  - Physical exercise
OT  - Sleep deprivation
EDAT- 2014/12/03 06:00
MHDA- 2015/12/30 06:00
CRDT- 2014/12/03 06:00
PHST- 2014/09/15 00:00 [received]
PHST- 2014/10/19 00:00 [revised]
PHST- 2014/11/11 00:00 [accepted]
PHST- 2014/12/03 06:00 [entrez]
PHST- 2014/12/03 06:00 [pubmed]
PHST- 2015/12/30 06:00 [medline]
AID - S0167-0115(14)00087-1 [pii]
AID - 10.1016/j.regpep.2014.11.004 [doi]
PST - ppublish
SO  - Regul Pept. 2014 Nov;194-195:11-5. doi: 10.1016/j.regpep.2014.11.004. Epub 2014 
      Nov 20.