PMID- 25451089
OWN - NLM
STAT- MEDLINE
DCOM- 20160523
LR  - 20220408
IS  - 1872-6240 (Electronic)
IS  - 0006-8993 (Linking)
VI  - 1621
DP  - 2015 Sep 24
TI  - Regulation of hippocampal synaptic plasticity by BDNF.
PG  - 82-101
LID - S0006-8993(14)01421-8 [pii]
LID - 10.1016/j.brainres.2014.10.019 [doi]
AB  - The neurotrophin brain-derived neurotrophic factor (BDNF) has emerged as a major 
      regulator of activity-dependent plasticity at excitatory synapses in the 
      mammalian central nervous system. In particular, much attention has been given to 
      the role of the neurotrophin in the regulation of hippocampal long-term 
      potentiation (LTP), a sustained enhancement of excitatory synaptic strength 
      believed to underlie learning and memory processes. In this review we summarize 
      the evidence pointing to a role for BDNF in generating functional and structural 
      changes at synapses required for both early- and late phases of LTP in the 
      hippocampus. The available information regarding the pre- and/or postsynaptic 
      release of BDNF and action of the neurotrophin during LTP will be also reviewed. 
      Finally, we discuss the effects of BDNF on the synaptic proteome, either by 
      acting on the protein synthesis machinery and/or by regulating protein 
      degradation by calpains and possibly by the ubiquitin-proteasome system (UPS). 
      This fine-tuned control of the synaptic proteome rather than a simple 
      upregulation of the protein synthesis may play a key role in BDNF-mediated 
      synaptic potentiation. This article is part of a Special Issue entitled SI: Brain 
      and Memory.
CI  - Copyright (c) 2014 Elsevier B.V. All rights reserved.
FAU - Leal, Graciano
AU  - Leal G
AD  - CNC-Center for Neuroscience and Cell Biology, University of Coimbra, 3004-517 
      Coimbra, Portugal.
FAU - Afonso, Pedro M
AU  - Afonso PM
AD  - CNC-Center for Neuroscience and Cell Biology, University of Coimbra, 3004-517 
      Coimbra, Portugal; Faculty of Pharmacy, University of Coimbra, 3000-548 Coimbra, 
      Portugal.
FAU - Salazar, Ivan L
AU  - Salazar IL
AD  - CNC-Center for Neuroscience and Cell Biology, University of Coimbra, 3004-517 
      Coimbra, Portugal; PhD Programme in Experimental Biology and Biomedicine (PDBEB) 
      and Institute for Interdisciplinary Research, University of Coimbra (IIIUC), 
      3030-789 Coimbra, Portugal.
FAU - Duarte, Carlos B
AU  - Duarte CB
AD  - CNC-Center for Neuroscience and Cell Biology, University of Coimbra, 3004-517 
      Coimbra, Portugal; Department of Life Sciences, University of Coimbra, 3004-517 
      Coimbra, Portugal. Electronic address: cbduarte@ci.uc.pt.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20141023
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/metabolism/*physiology
MH  - Dendritic Spines/metabolism/*physiology
MH  - Hippocampus/metabolism/*physiology
MH  - Humans
MH  - *Long-Term Potentiation
MH  - Long-Term Synaptic Depression
MH  - Signal Transduction
MH  - Synapses/metabolism/*physiology
OTO - NOTNLM
OT  - BDNF
OT  - Long-term potentiation (LTP)
OT  - Neurotrophins
OT  - Synaptic plasticity
OT  - Translation
OT  - Ubiquitin-proteasome system (UPS)
EDAT- 2014/12/03 06:00
MHDA- 2016/05/24 06:00
CRDT- 2014/12/03 06:00
PHST- 2014/07/01 00:00 [received]
PHST- 2014/10/10 00:00 [revised]
PHST- 2014/10/13 00:00 [accepted]
PHST- 2014/12/03 06:00 [entrez]
PHST- 2014/12/03 06:00 [pubmed]
PHST- 2016/05/24 06:00 [medline]
AID - S0006-8993(14)01421-8 [pii]
AID - 10.1016/j.brainres.2014.10.019 [doi]
PST - ppublish
SO  - Brain Res. 2015 Sep 24;1621:82-101. doi: 10.1016/j.brainres.2014.10.019. Epub 
      2014 Oct 23.