PMID- 25451115
OWN - NLM
STAT- MEDLINE
DCOM- 20150824
LR  - 20141229
IS  - 1872-6240 (Electronic)
IS  - 0006-8993 (Linking)
VI  - 1596
DP  - 2015 Jan 30
TI  - Iron administration prevents BDNF decrease and depressive-like behavior following 
      chronic stress.
PG  - 79-87
LID - S0006-8993(14)01479-6 [pii]
LID - 10.1016/j.brainres.2014.10.057 [doi]
AB  - Pro-inflammatory cytokines play important roles in responses to stresses and 
      affect iron metabolism. Iron is essential for survival of hippocampus neurons and 
      plays a role in depression. Noting the close causal effect relation between 
      stress and depression, in this experimental study we investigated the influence 
      of iron on stress-induced depression. Rats were exposed to chronic mild stress 
      and were treated with three different iron doses (9, 12, and 20mg/kg) three times 
      a week for four weeks with an iron chelator in the first and third week. Serum 
      interleukin-6 (enzyme-linked immune sorbent assay), hippocampus iron content 
      (atomic absorption spectrometry), brain-derived neurotrophic factor (BDNF) gene 
      expression (real-time polymerase chain reaction), CA1 pyramidal cell count (Nissl 
      method) and a behavioral test (forced swimming test) were evaluated. In both the 
      stressed and stressed plus iron groups, hippocampus cell counts were lower than 
      in the control group (non-stressed). The use of deferiprone in the stressed 
      groups markedly prevented neuronal loss. In stressed rats, the iron content of 
      the hippocampus was higher than in the control group (P<0.001). Moreover, in the 
      stressed group with moderate iron administration (12 mg/kg), there was a 
      significant elevation of BDNF expression (P<0.05) and decreased immobility 
      behavior time (P<0.05). These results indicate that high doses of iron in 
      stressful situations augment neuronal degeneration and loss, possibly by iron 
      accumulation. Deferiprone as an iron chelator could reverse this effect. During 
      chronic mild stress, cerebrospinal fluid possibly reduces the iron content and 
      may result in reduction of monoamines being involved in mood regulation. Iron 
      administration in a moderate dose can increase these neurotransmitters and BDNF 
      expression.
CI  - Copyright (c) 2014 Elsevier B.V. All rights reserved.
FAU - Mehrpouya, Sara
AU  - Mehrpouya S
AD  - Physiology Research Center, School of Medicine, Iran University of Medical 
      Sciences, Tehran, Iran.
FAU - Nahavandi, Arezo
AU  - Nahavandi A
AD  - Physiology Research Center, School of Medicine, Iran University of Medical 
      Sciences, Tehran, Iran; Department of Physiology, School of Medicine, Iran 
      University of Medical Sciences, Tehran, Iran; Cellular and Molecular Research 
      Center, Iran University of Medical Sciences, Tehran, Iran. Electronic address: 
      arezoonahavandi1999@gmail.com.
FAU - Khojasteh, Fatemeh
AU  - Khojasteh F
AD  - Physiology Research Center, School of Medicine, Iran University of Medical 
      Sciences, Tehran, Iran.
FAU - Soleimani, Mansoureh
AU  - Soleimani M
AD  - Cellular and Molecular Research Center, Iran University of Medical Sciences, 
      Tehran, Iran.
FAU - Ahmadi, Mohammad
AU  - Ahmadi M
AD  - Physiology Research Center, School of Medicine, Iran University of Medical 
      Sciences, Tehran, Iran.
FAU - Barati, Mahmood
AU  - Barati M
AD  - Department of Biotechnology, Shahid Beheshti University of Medical Sciences, 
      Tehran, Iran.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141113
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Interleukin-6)
RN  - 0 (Trace Elements)
RN  - E1UOL152H7 (Iron)
SB  - IM
MH  - Analysis of Variance
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/genetics/*metabolism
MH  - Chronic Disease
MH  - Depression/*drug therapy/*etiology
MH  - Disease Models, Animal
MH  - Dose-Response Relationship, Drug
MH  - Hippocampus/drug effects/metabolism
MH  - Interleukin-6/metabolism
MH  - Iron/*administration & dosage/metabolism
MH  - Male
MH  - Rats
MH  - Rats, Wistar
MH  - Stress, Psychological/*complications
MH  - Swimming/psychology
MH  - Time Factors
MH  - Trace Elements/*administration & dosage
OTO - NOTNLM
OT  - Brain-derived neurotrophic factor
OT  - Hippocampus
OT  - Iron
OT  - Stress-induced depression
EDAT- 2014/12/03 06:00
MHDA- 2015/08/25 06:00
CRDT- 2014/12/03 06:00
PHST- 2014/09/02 00:00 [received]
PHST- 2014/10/26 00:00 [revised]
PHST- 2014/10/27 00:00 [accepted]
PHST- 2014/12/03 06:00 [entrez]
PHST- 2014/12/03 06:00 [pubmed]
PHST- 2015/08/25 06:00 [medline]
AID - S0006-8993(14)01479-6 [pii]
AID - 10.1016/j.brainres.2014.10.057 [doi]
PST - ppublish
SO  - Brain Res. 2015 Jan 30;1596:79-87. doi: 10.1016/j.brainres.2014.10.057. Epub 2014 
      Nov 13.