PMID- 25451116
OWN - NLM
STAT- MEDLINE
DCOM- 20160927
LR  - 20181113
IS  - 1872-6240 (Electronic)
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 1628
IP  - Pt A
DP  - 2015 Dec 2
TI  - Brain-derived neurotrophic factor and addiction: Pathological versus therapeutic 
      effects on drug seeking.
PG  - 68-81
LID - S0006-8993(14)01480-2 [pii]
LID - 10.1016/j.brainres.2014.10.058 [doi]
AB  - Many abused drugs lead to changes in endogenous brain-derived neurotrophic factor 
      (BDNF) expression in neural circuits responsible for addictive behaviors. BDNF is 
      a known molecular mediator of memory consolidation processes, evident at both 
      behavioral and neurophysiological levels. Specific neural circuits are 
      responsible for storing and executing drug-procuring motor programs, whereas 
      other neural circuits are responsible for the active suppression of these 
      "seeking" systems. These seeking-circuits are established as associations are 
      formed between drug-associated cues and the conditioned responses they elicit. 
      Such conditioned responses (e.g. drug seeking) can be diminished either through a 
      passive weakening of seeking- circuits or an active suppression of those circuits 
      through extinction. Extinction learning occurs when the association between cues 
      and drug are violated, for example, by cue exposure without the drug present. Cue 
      exposure therapy has been proposed as a therapeutic avenue for the treatment of 
      addictions. Here we explore the role of BDNF in extinction circuits, compared to 
      seeking-circuits that "incubate" over prolonged withdrawal periods. We begin by 
      discussing the role of BDNF in extinction memory for fear and cocaine-seeking 
      behaviors, where extinction circuits overlap in infralimbic prefrontal cortex 
      (PFC). We highlight the ability of estrogen to promote BDNF-like effects in 
      hippocampal-prefrontal circuits and consider the role of sex differences in 
      extinction and incubation of drug-seeking behaviors. Finally, we examine how 
      opiates and alcohol "break the mold" in terms of BDNF function in extinction 
      circuits.
CI  - Copyright (c) 2014. Published by Elsevier B.V.
FAU - Barker, Jacqueline M
AU  - Barker JM
AD  - Department of Neurosciences, Medical University of South Carolina, Charleston, SC 
      29425, USA.
FAU - Taylor, Jane R
AU  - Taylor JR
AD  - Department of Psychiatry, Yale University School of Medicine, New Haven, CT 
      06519, USA.
FAU - De Vries, Taco J
AU  - De Vries TJ
AD  - Department of Anatomy and Neurosciences, Neuroscience Campus Amsterdam, VU 
      University Medical Center, 1081 BT Amsterdam, The Netherlands; Department of 
      Molecular and Cellular Neurobiology, Neuroscience Campus Amsterdam, Center for 
      Neurogenomics and Cognitive Research, Faculty of Earth and Life Sciences, VU 
      University, 1081 HV Amsterdam, The Netherlands.
FAU - Peters, Jamie
AU  - Peters J
AD  - Department of Neurosciences, Medical University of South Carolina, Charleston, SC 
      29425, USA. Electronic address: petersjl.upr@gmail.com.
LA  - eng
GR  - P50AA012870/AA/NIAAA NIH HHS/United States
GR  - F32 AA023141/AA/NIAAA NIH HHS/United States
GR  - AA020135/AA/NIAAA NIH HHS/United States
GR  - AA023141/AA/NIAAA NIH HHS/United States
GR  - F31 AA020135/AA/NIAAA NIH HHS/United States
GR  - DA038235/DA/NIDA NIH HHS/United States
GR  - P50 AA012870/AA/NIAAA NIH HHS/United States
GR  - K01 DA038235/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20141104
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Drug-Seeking Behavior/*physiology
MH  - Humans
MH  - Substance-Related Disorders/*metabolism/therapy
PMC - PMC4425618
MID - NIHMS680567
OTO - NOTNLM
OT  - Alcohol
OT  - Brain-derived neurotrophic factor
OT  - Cocaine
OT  - Extinction memory
OT  - Hippocampal-prefrontal systems
OT  - Opiates
EDAT- 2014/12/03 06:00
MHDA- 2016/09/28 06:00
PMCR- 2016/12/02
CRDT- 2014/12/03 06:00
PHST- 2014/09/08 00:00 [received]
PHST- 2014/10/20 00:00 [revised]
PHST- 2014/10/27 00:00 [accepted]
PHST- 2014/12/03 06:00 [entrez]
PHST- 2014/12/03 06:00 [pubmed]
PHST- 2016/09/28 06:00 [medline]
PHST- 2016/12/02 00:00 [pmc-release]
AID - S0006-8993(14)01480-2 [pii]
AID - 10.1016/j.brainres.2014.10.058 [doi]
PST - ppublish
SO  - Brain Res. 2015 Dec 2;1628(Pt A):68-81. doi: 10.1016/j.brainres.2014.10.058. Epub 
      2014 Nov 4.