PMID- 25451308
OWN - NLM
STAT- MEDLINE
DCOM- 20150807
LR  - 20141209
IS  - 1095-9564 (Electronic)
IS  - 1074-7427 (Linking)
VI  - 116
DP  - 2014 Dec
TI  - Acute infusion of brain-derived neurotrophic factor in the insular cortex 
      promotes conditioned taste aversion extinction.
PG  - 139-44
LID - S1074-7427(14)00186-5 [pii]
LID - 10.1016/j.nlm.2014.10.007 [doi]
AB  - Brain-derived neurotrophic factor (BDNF) has emerged as one of the most potent 
      molecular mediators not only for synaptic plasticity, but also for the behavioral 
      organism-environment interactions. Our previous studies in the insular cortex 
      (IC), a neocortical region that has been related with acquisition and retention 
      of conditioned taste aversion (CTA), have demonstrated that intracortical 
      microinfusion of BDNF induces a lasting potentiation of synaptic efficacy in the 
      basolateral amygdaloid nucleus (Bla)-IC projection and enhances the retention of 
      CTA memory of adult rats in vivo. The aim of the present study was to analyze 
      whether acute BDNF-infusion in the IC modifies the extinction of CTA. 
      Accordingly, animals were trained in the CTA task and received bilateral IC 
      microinfusions of BDNF before extinction training. Our results showed that taste 
      aversion was significantly reduced in BDNF rats from the first extinction trial. 
      Additionally, we found that the effect of BDNF on taste aversion did not require 
      extinction training. Finally we showed that the BDNF effect does not degrade the 
      original taste aversion memory trace. These results emphasize that BDNF activity 
      underlies memory extinction in neocortical areas and support the idea that BDNF 
      is a key regulator and mediator of long-term synaptic modifications.
CI  - Copyright (c) 2014 Elsevier Inc. All rights reserved.
FAU - Rodriguez-Serrano, Luis M
AU  - Rodriguez-Serrano LM
AD  - Division de Investigacion y Estudios de Posgrado, Facultad de Psicologia, 
      Universidad Nacional Autonoma de Mexico, Mexico D.F., Mexico.
FAU - Ramirez-Leon, Betsabee
AU  - Ramirez-Leon B
AD  - Division de Investigacion y Estudios de Posgrado, Facultad de Psicologia, 
      Universidad Nacional Autonoma de Mexico, Mexico D.F., Mexico.
FAU - Rodriguez-Duran, Luis F
AU  - Rodriguez-Duran LF
AD  - Division de Investigacion y Estudios de Posgrado, Facultad de Psicologia, 
      Universidad Nacional Autonoma de Mexico, Mexico D.F., Mexico.
FAU - Escobar, Martha L
AU  - Escobar ML
AD  - Division de Investigacion y Estudios de Posgrado, Facultad de Psicologia, 
      Universidad Nacional Autonoma de Mexico, Mexico D.F., Mexico. Electronic address: 
      mescobar@unam.mx.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141025
PL  - United States
TA  - Neurobiol Learn Mem
JT  - Neurobiology of learning and memory
JID - 9508166
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Animals
MH  - Avoidance Learning/*drug effects
MH  - Brain-Derived Neurotrophic Factor/*pharmacology
MH  - Cerebral Cortex/*drug effects
MH  - Conditioning, Classical/*drug effects
MH  - Extinction, Psychological/*drug effects
MH  - Male
MH  - Rats
MH  - Rats, Wistar
MH  - Taste/*drug effects
OTO - NOTNLM
OT  - BDNF
OT  - CTA
OT  - Extinction
OT  - Insular cortex
OT  - Neocortical plasticity
EDAT- 2014/12/03 06:00
MHDA- 2015/08/08 06:00
CRDT- 2014/12/03 06:00
PHST- 2014/05/23 00:00 [received]
PHST- 2014/09/29 00:00 [revised]
PHST- 2014/10/13 00:00 [accepted]
PHST- 2014/12/03 06:00 [entrez]
PHST- 2014/12/03 06:00 [pubmed]
PHST- 2015/08/08 06:00 [medline]
AID - S1074-7427(14)00186-5 [pii]
AID - 10.1016/j.nlm.2014.10.007 [doi]
PST - ppublish
SO  - Neurobiol Learn Mem. 2014 Dec;116:139-44. doi: 10.1016/j.nlm.2014.10.007. Epub 
      2014 Oct 25.