PMID- 25451398
OWN - NLM
STAT- MEDLINE
DCOM- 20160912
LR  - 20220318
IS  - 1573-2517 (Electronic)
IS  - 0165-0327 (Linking)
VI  - 172
DP  - 2015 Feb 1
TI  - Association of brain-derived neurotrophic factor DNA methylation and reduced 
      white matter integrity in the anterior corona radiata in major depression.
PG  - 74-80
LID - S0165-0327(14)00596-5 [pii]
LID - 10.1016/j.jad.2014.09.042 [doi]
AB  - Considerable evidence suggests a crucial role for the epigenetic regulation of 
      brain-derived neurotrophic factor (BDNF) in the pathophysiology of major 
      depressive disorder (MDD). However, the relationship between BDNF DNA methylation 
      and white matter (WM) integrity in MDD has not yet been investigated. In the 
      current study, we examined the association between the DNA methylation status of 
      the BDNF promoter region and WM integrity in MDD. Sixty patients with MDD and 53 
      healthy controls underwent T1-weighted structural magnetic resonance imaging 
      (MRI), including diffusion tensor imaging (DTI), to assess their WM integrity. 
      BDNF DNA methylation at 4 CpG sites of the promoter region was also measured. As 
      compared to healthy controls, the MDD group demonstrated reduced fractional 
      anisotropy (FA) in the bilateral anterior and posterior corona radiata (ACR and 
      PCR), genu of the corpus callosum, and the bilateral posterior thalamic 
      radiations. We observed a significant inverse correlation between the DNA 
      methylation of the BDNF promoter region and the FA of the right ACR in MDD 
      patients. Our findings demonstrate a relationship between methylation of the BDNF 
      promoter region and the integrity of the ACR, a key structural component of the 
      emotional and cognitive control network involved in the pathophysiology of MDD. 
      This correlation suggests that BDNF DNA methylation may contribute to structural 
      WM changes in MDD patients.
CI  - Copyright (c) 2014 Elsevier B.V. All rights reserved.
FAU - Choi, Sunyoung
AU  - Choi S
AD  - Department of Brain and Cognitive Engineering, Korea University, Seoul, Republic 
      of Korea.
FAU - Han, Kyu-Man
AU  - Han KM
AD  - Department of Psychiatry, Korea University College of Medicine, Seoul, Republic 
      of Korea.
FAU - Won, Eunsoo
AU  - Won E
AD  - Department of Brain and Cognitive Engineering, Korea University, Seoul, Republic 
      of Korea.
FAU - Yoon, Bong-June
AU  - Yoon BJ
AD  - Division of Life Sciences, College of Life Sciences and biotechnology, Korea 
      University, Seoul, Republic of Korea.
FAU - Lee, Min-Soo
AU  - Lee MS
AD  - Department of Psychiatry, Korea University College of Medicine, Seoul, Republic 
      of Korea.
FAU - Ham, Byung-Joo
AU  - Ham BJ
AD  - Department of Psychiatry, Korea University College of Medicine, Seoul, Republic 
      of Korea. Electronic address: hambj@chol.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141006
PL  - Netherlands
TA  - J Affect Disord
JT  - Journal of affective disorders
JID - 7906073
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Adult
MH  - Anisotropy
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Case-Control Studies
MH  - Cognition
MH  - Corpus Callosum/pathology
MH  - *DNA Methylation
MH  - Depressive Disorder, Major/*genetics/*pathology
MH  - Diffusion Tensor Imaging
MH  - Emotions
MH  - *Epigenesis, Genetic
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Republic of Korea
MH  - Thalamus/pathology
MH  - White Matter/*pathology
OTO - NOTNLM
OT  - Anterior corona radiata
OT  - Brain-derived neurotrophic factor (BDNF)
OT  - DNA methylation
OT  - Diffusion tensor imaging (DTI)
OT  - Major depressive disorder
EDAT- 2014/12/03 06:00
MHDA- 2016/09/13 06:00
CRDT- 2014/12/03 06:00
PHST- 2014/06/11 00:00 [received]
PHST- 2014/09/22 00:00 [revised]
PHST- 2014/09/23 00:00 [accepted]
PHST- 2014/12/03 06:00 [entrez]
PHST- 2014/12/03 06:00 [pubmed]
PHST- 2016/09/13 06:00 [medline]
AID - S0165-0327(14)00596-5 [pii]
AID - 10.1016/j.jad.2014.09.042 [doi]
PST - ppublish
SO  - J Affect Disord. 2015 Feb 1;172:74-80. doi: 10.1016/j.jad.2014.09.042. Epub 2014 
      Oct 6.