PMID- 25451444
OWN - NLM
STAT- MEDLINE
DCOM- 20161025
LR  - 20181202
IS  - 1573-2517 (Electronic)
IS  - 0165-0327 (Linking)
VI  - 172
DP  - 2015 Feb 1
TI  - Serum triglycerides, but not cholesterol or leptin, are decreased in suicide 
      attempters with mood disorders.
PG  - 403-9
LID - S0165-0327(14)00655-7 [pii]
LID - 10.1016/j.jad.2014.10.033 [doi]
AB  - BACKGROUND: Many peripheral biomarkers, including low cholesterol and its 
      fractions, have been examined to identify suicidal behavior. Herein, we assessed 
      serum lipid profile and some proteins putatively associated with suicidal 
      behavior in subjects with mood disorder (bipolar disorder or major depressive 
      disorder) with a recent suicide attempt and with no lifetime history of suicide 
      attempts. METHODS: Fifty subjects had presented an episode of attempted suicide 
      during the last 15 days, and 36 subjects had no history of any suicide attempt. 
      We measured total cholesterol, HDL, LDL and triglycerides as well as serum 
      leptin, brain-derived neurotrophic factor (BDNF), S100B and C-reactive protein 
      (CRP). RESULTS: Individuals that had attempted suicide presented decreased body 
      mass index (BMI) and waist circumference. After adjusting for these confounders, 
      we found that triglycerides were decreased in attempted suicide subjects. We 
      found no differences among total cholesterol, LDL, and HDL or leptin, S100B, CRP 
      and BDNF. LIMITATIONS: This is a cross-sectional study, and we cannot therefore 
      assess whether a decrease in triglycerides caused a mood episode with suicidal 
      ideation that led to a suicide attempt or if the presence of a mood episode 
      originated a loss of appetite and consequent loss of weight, therefore decreasing 
      triglyceride levels. CONCLUSIONS: These results do not support the hypothesis 
      that lower levels of cholesterol are associated with suicidal behavior in a mood 
      disorder sample. However, our data support the idea that adiposity is 
      differentiated in these patients (reduced BMI, waist circumference and serum 
      triglycerides), which could lead to an altered communication between the adipose 
      tissue and brain.
CI  - Copyright (c) 2014 The Authors. Published by Elsevier B.V. All rights reserved.
FAU - da Graca Cantarelli, Maria
AU  - da Graca Cantarelli M
AD  - Post Graduate Program in Neuroscience, Federal University of Rio Grande do 
      Sul,Porto Alegre, Brazil.
FAU - Nardin, Patricia
AU  - Nardin P
AD  - Laboratory of Calcium Binding Proteins in the Central Nervous System, Post 
      Graduate Program in Biochemistry, Federal University of Rio Grande do Sul, Porto 
      Alegre, Brazil.
FAU - Buffon, Andreia
AU  - Buffon A
AD  - Faculty of Pharmacy, Federal University of Rio Grande do Sul, Porto Alegre, 
      Brazil.
FAU - Eidt, Murilo Castilhos
AU  - Eidt MC
AD  - Study Center Jose de Barros Falcao, Porto Alegre, Brazil.
FAU - Antonio Godoy, Luiz
AU  - Antonio Godoy L
AD  - Sao Jose Psychiatric Clinic, Porto Alegre, Brazil.
FAU - Fernandes, Brisa S
AU  - Fernandes BS
AD  - Laboratory of Calcium Binding Proteins in the Central Nervous System, Post 
      Graduate Program in Biochemistry, Federal University of Rio Grande do Sul, Porto 
      Alegre, Brazil.
FAU - Goncalves, Carlos-Alberto
AU  - Goncalves CA
AD  - Post Graduate Program in Neuroscience, Federal University of Rio Grande do 
      Sul,Porto Alegre, Brazil; Laboratory of Calcium Binding Proteins in the Central 
      Nervous System, Post Graduate Program in Biochemistry, Federal University of Rio 
      Grande do Sul, Porto Alegre, Brazil. Electronic address: casg@ufrgs.br.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141022
PL  - Netherlands
TA  - J Affect Disord
JT  - Journal of affective disorders
JID - 7906073
RN  - 0 (Biomarkers)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Leptin)
RN  - 0 (Triglycerides)
RN  - 7171WSG8A2 (BDNF protein, human)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - 97C5T2UQ7J (Cholesterol)
SB  - IM
MH  - Adult
MH  - Biomarkers/blood
MH  - Bipolar Disorder/blood/complications
MH  - Brain-Derived Neurotrophic Factor/blood
MH  - C-Reactive Protein/metabolism
MH  - Cholesterol/blood
MH  - Cross-Sectional Studies
MH  - Depressive Disorder, Major/blood/complications
MH  - Female
MH  - Humans
MH  - Leptin/blood
MH  - Male
MH  - Middle Aged
MH  - Mood Disorders/*blood/*complications
MH  - Suicidal Ideation
MH  - *Suicide, Attempted
MH  - Triglycerides/*blood
OTO - NOTNLM
OT  - Cholesterol
OT  - Leptin
OT  - Mood affective disorders
OT  - Suicide
OT  - Triglycerides
EDAT- 2014/12/03 06:00
MHDA- 2016/10/26 06:00
CRDT- 2014/12/03 06:00
PHST- 2014/10/08 00:00 [received]
PHST- 2014/10/14 00:00 [accepted]
PHST- 2014/12/03 06:00 [entrez]
PHST- 2014/12/03 06:00 [pubmed]
PHST- 2016/10/26 06:00 [medline]
AID - S0165-0327(14)00655-7 [pii]
AID - 10.1016/j.jad.2014.10.033 [doi]
PST - ppublish
SO  - J Affect Disord. 2015 Feb 1;172:403-9. doi: 10.1016/j.jad.2014.10.033. Epub 2014 
      Oct 22.