PMID- 25451721
OWN - NLM
STAT- MEDLINE
DCOM- 20150623
LR  - 20141216
IS  - 1872-7972 (Electronic)
IS  - 0304-3940 (Linking)
VI  - 584
DP  - 2015 Jan 1
TI  - The effects of lobeline on depression-like behavior and hippocampal cell 
      proliferation following chronic stress in mice.
PG  - 7-11
LID - S0304-3940(14)00813-1 [pii]
LID - 10.1016/j.neulet.2014.10.009 [doi]
AB  - We have reported that brain nicotinic acetylcholine receptor (nAChR) ligand 
      lobeline has antidepressant-like effects in mice. The present study examined the 
      effects of lobeline on chronic unpredictable stress (CUS)-induced depression-like 
      behavior, deficits in brain-derived neurotrophic factor (BDNF) expression and 
      cell proliferation in the hippocampus. Adult C57BL/6J mice were exposed to CUS 
      for 6 weeks. Lobeline (1 or 4 mg/kg, s.c.) or saline was administered once daily 
      during the last 14 days of CUS. CUS-exposed mice showed increased immobility time 
      in the FST compared to control. Pretreatment with lobeline (1 mg/kg) 
      significantly reduced immobility time in the CUS-exposed mice. Twenty-four hour 
      following lobeline or saline treatment, BDNF expression or cell proliferation was 
      measured in the hippocampus using Western blotting and bromodeoxyuridine 
      immunohistochemistry, respectively. Lobeline (1 mg/kg) treatment prevented 
      CUS-induced reduction in BDNF expression and cell proliferation in the 
      hippocampus. Overall, our findings suggest that antidepressant-like effects of 
      lobeline could involve nAChR mediated signaling, BDNF expression, and/or 
      hippocampal cell proliferation.
CI  - Copyright (c) 2014 Elsevier Ireland Ltd. All rights reserved.
FAU - Roni, Monzurul Amin
AU  - Roni MA
AD  - Department of Pharmaceutical Sciences, College of Pharmacy, South Dakota State 
      University, Brookings, SD 57007, USA.
FAU - Rahman, Shafiqur
AU  - Rahman S
AD  - Department of Pharmaceutical Sciences, College of Pharmacy, South Dakota State 
      University, Brookings, SD 57007, USA. Electronic address: 
      Shafiqur.Rahman@sdstate.edu.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141019
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Antidepressive Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - D0P25S3P81 (Lobeline)
SB  - IM
MH  - Animals
MH  - Antidepressive Agents/*pharmacology
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Cell Proliferation
MH  - Chronic Disease
MH  - Depression/etiology/pathology/*psychology
MH  - Hippocampus/*drug effects/metabolism/pathology
MH  - Lobeline/*pharmacology
MH  - Male
MH  - Mice, Inbred C57BL
MH  - Stress, Psychological/complications/pathology/*psychology
OTO - NOTNLM
OT  - BDNF
OT  - Chronic stress
OT  - Hippocampus
OT  - Lobeline
OT  - Major depression
OT  - Nicotinic receptor
EDAT- 2014/12/03 06:00
MHDA- 2015/06/24 06:00
CRDT- 2014/12/03 06:00
PHST- 2014/06/09 00:00 [received]
PHST- 2014/10/06 00:00 [revised]
PHST- 2014/10/08 00:00 [accepted]
PHST- 2014/12/03 06:00 [entrez]
PHST- 2014/12/03 06:00 [pubmed]
PHST- 2015/06/24 06:00 [medline]
AID - S0304-3940(14)00813-1 [pii]
AID - 10.1016/j.neulet.2014.10.009 [doi]
PST - ppublish
SO  - Neurosci Lett. 2015 Jan 1;584:7-11. doi: 10.1016/j.neulet.2014.10.009. Epub 2014 
      Oct 19.