PMID- 25451722
OWN - NLM
STAT- MEDLINE
DCOM- 20150623
LR  - 20220330
IS  - 1872-7972 (Electronic)
IS  - 0304-3940 (Linking)
VI  - 584
DP  - 2015 Jan 1
TI  - Retinal neurodegeneration on optical coherence tomography and cerebral atrophy.
PG  - 12-6
LID - S0304-3940(14)00814-3 [pii]
LID - 10.1016/j.neulet.2014.10.010 [doi]
AB  - Neurodegeneration in dementia is mainly evaluated by assessing cerebral atrophy, 
      while retinal neurodegeneration can be quantified in vivo using optical coherence 
      tomography (OCT). We examined the association of retinal nerve fibre layer (RNFL) 
      and ganglion cell-inner plexiform layer (GC-IPL) thinning with global and 
      regional cerebral atrophy on magnetic resonance imaging (MRI). Malay participants 
      aged 60-80 years from the Epidemiology of Dementia in Singapore Study underwent 
      comprehensive examinations, including 3-Tesla cranial MRI. RNFL and GC-IPL 
      thicknesses were obtained from spectral domain-OCT; and cerebral grey and white 
      matter volumes were obtained from MRI scans using a validated segmentation tool. 
      Linear regression models were constructed with adjustment for age and sex; and 
      additionally for vascular risk factors and MRI markers including intracranial 
      volume. 164 participants without glaucoma with gradable quality MRI and OCT scans 
      were included for analysis. GC-IPL thinning was associated with reduction in 
      total brain volume in the occipital (mean change in GC-IPL per standard deviation 
      (SD) decrease in occipital lobe volume: -1.77 mum, 95% confidence interval (CI) 
      -6.55 to 0.01 mum) and temporal lobes (mean change in GC-IPL per SD decrease in 
      temporal lobe volume: -3.45 mum, 95%CI -5.40 to -1.49 mum) in multivariate adjusted 
      models. In particular, GC-IPL thinning was primarily associated with grey matter 
      volume, whereas no association was found with white matter changes. Retinal 
      neuronal damage, as reflected by GC-IPL thinning, was independently associated 
      with grey matter loss in the occipital and temporal lobes, suggesting that 
      retinal OCT may provide insights for assessing neurodegeneration in the brain.
CI  - Copyright (c) 2014 Elsevier Ireland Ltd. All rights reserved.
FAU - Ong, Yi-Ting
AU  - Ong YT
AD  - Singapore Eye Research Institute, Singapore National Eye Center, Singapore, 
      Singapore; NUS Graduate School for Integrative Sciences and Engineering, National 
      University of Singapore, Singapore, Singapore; Department of Ophthalmology, Yong 
      Loo Lin School of Medicine, National University of Singapore, Singapore, 
      Singapore.
FAU - Hilal, Saima
AU  - Hilal S
AD  - Department of Ophthalmology, Yong Loo Lin School of Medicine, National University 
      of Singapore, Singapore, Singapore; Memory, Aging and Cognition Center, National 
      University Health System, Singapore, Singapore; Department of Pharmacology, 
      National University of Singapore, Singapore, Singapore.
FAU - Cheung, Carol Y
AU  - Cheung CY
AD  - Singapore Eye Research Institute, Singapore National Eye Center, Singapore, 
      Singapore; Department of Ophthalmology, Yong Loo Lin School of Medicine, National 
      University of Singapore, Singapore, Singapore; Ophthalmology and Visual Science 
      Academic Clinical Program, Duke-NUS Graduate Medical School, National University 
      of Singapore, Singapore, Singapore.
FAU - Venketasubramanian, Narayanaswamy
AU  - Venketasubramanian N
AD  - Rafffles Neuroscience Centre, Raffles Hospital, Singapore, Singapore.
FAU - Niessen, Wiro J
AU  - Niessen WJ
AD  - Departments of Radiology & Medical Informatics, Erasmus Medical Center, 
      Rotterdam, The Netherlands; Faculty of Applied Sciences, Delft University of 
      Technology, Delft, The Netherlands.
FAU - Vrooman, Henri
AU  - Vrooman H
AD  - Departments of Radiology & Medical Informatics, Erasmus Medical Center, 
      Rotterdam, The Netherlands; Faculty of Applied Sciences, Delft University of 
      Technology, Delft, The Netherlands.
FAU - Anuar, Ainur R
AU  - Anuar AR
AD  - Singapore Eye Research Institute, Singapore National Eye Center, Singapore, 
      Singapore.
FAU - Chew, Merwyn
AU  - Chew M
AD  - Singapore Eye Research Institute, Singapore National Eye Center, Singapore, 
      Singapore; Department of Ophthalmology, Yong Loo Lin School of Medicine, National 
      University of Singapore, Singapore, Singapore.
FAU - Chen, Christopher
AU  - Chen C
AD  - Memory, Aging and Cognition Center, National University Health System, Singapore, 
      Singapore; Department of Pharmacology, National University of Singapore, 
      Singapore, Singapore.
FAU - Wong, Tien Yin
AU  - Wong TY
AD  - Singapore Eye Research Institute, Singapore National Eye Center, Singapore, 
      Singapore; Department of Ophthalmology, Yong Loo Lin School of Medicine, National 
      University of Singapore, Singapore, Singapore; Ophthalmology and Visual Science 
      Academic Clinical Program, Duke-NUS Graduate Medical School, National University 
      of Singapore, Singapore, Singapore.
FAU - Ikram, Mohammad Kamran
AU  - Ikram MK
AD  - Singapore Eye Research Institute, Singapore National Eye Center, Singapore, 
      Singapore; Memory, Aging and Cognition Center, National University Health System, 
      Singapore, Singapore; Ophthalmology and Visual Science Academic Clinical Program, 
      Duke-NUS Graduate Medical School, National University of Singapore, Singapore, 
      Singapore; Academic Medicine Research Institute, Duke-NUS Graduate Medical 
      School, Singapore, Singapore. Electronic address: kamran_ikram@nuhs.edu.sg.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141019
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Atrophy
MH  - Brain/*pathology
MH  - Female
MH  - Gray Matter/pathology
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Nerve Degeneration/*pathology
MH  - Nerve Fibers/pathology
MH  - Retina/*pathology
MH  - Retinal Ganglion Cells/pathology
MH  - Tomography, Optical Coherence
MH  - White Matter/pathology
OTO - NOTNLM
OT  - Cerebral atrophy
OT  - Ganglion cell
OT  - Grey matter
OT  - Occipital lobe
OT  - Retina
OT  - Temporal lobe
EDAT- 2014/12/03 06:00
MHDA- 2015/06/24 06:00
CRDT- 2014/12/03 06:00
PHST- 2014/07/11 00:00 [received]
PHST- 2014/10/03 00:00 [revised]
PHST- 2014/10/08 00:00 [accepted]
PHST- 2014/12/03 06:00 [entrez]
PHST- 2014/12/03 06:00 [pubmed]
PHST- 2015/06/24 06:00 [medline]
AID - S0304-3940(14)00814-3 [pii]
AID - 10.1016/j.neulet.2014.10.010 [doi]
PST - ppublish
SO  - Neurosci Lett. 2015 Jan 1;584:12-6. doi: 10.1016/j.neulet.2014.10.010. Epub 2014 
      Oct 19.