PMID- 25452083
OWN - NLM
STAT- MEDLINE
DCOM- 20151028
LR  - 20150202
IS  - 1615-5947 (Electronic)
IS  - 0890-5096 (Linking)
VI  - 29
IP  - 2
DP  - 2015 Feb
TI  - Adverse events after treatment of patients with acute limb ischemia.
PG  - 293-302
LID - S0890-5096(14)00681-5 [pii]
LID - 10.1016/j.avsg.2014.10.022 [doi]
AB  - BACKGROUND: To assess the outcome and the occurrence and consequences of adverse 
      events (AEs) after treatment of acute limb ischemia (ALI). METHODS: Retrospective 
      analysis on intra-arterial thrombolysis (group I) and thromboembolectomy (group 
      II). Outcome measures were primary patency and limb salvage rates. AEs and 
      consequences were registered during admission and 30 days after discharge. 
      RESULTS: A total of 238 procedures were included (group I, 173 vs. group II, 65). 
      The primary patency (P = 0.144) and limb salvage rates (P = 0.166) were not 
      significantly different between both groups. A total of 195 AEs were registered. 
      Most AEs were procedure related and resulted in surgical reintervention (77% vs. 
      76%). Some AEs resulted in irreversible physical damage (15% vs. 25%) and death 
      (6% vs. 12%). CONCLUSIONS: Both, intra-arterial thrombolysis and 
      thromboembolectomies are adequate therapies; however, they result in a wide 
      variety of AEs resulting in serious morbidity and even death.
CI  - Copyright (c) 2015 Elsevier Inc. All rights reserved.
FAU - van der Slegt, Jasper
AU  - van der Slegt J
AD  - Department of Surgery, Amphia Hospital, Breda, The Netherlands. Electronic 
      address: JvanderSlegt@amphia.nl.
FAU - Flu, Hans C
AU  - Flu HC
AD  - Department of Surgery, Amphia Hospital, Breda, The Netherlands.
FAU - Veen, Eelco J
AU  - Veen EJ
AD  - Department of Surgery, Amphia Hospital, Breda, The Netherlands.
FAU - Ho, Gwan H
AU  - Ho GH
AD  - Department of Surgery, Amphia Hospital, Breda, The Netherlands.
FAU - de Groot, Hans G W
AU  - de Groot HG
AD  - Department of Surgery, Amphia Hospital, Breda, The Netherlands.
FAU - Vos, Louwerens D
AU  - Vos LD
AD  - Department of Radiology, Amphia Hospital, Breda, The Netherlands.
FAU - van der Laan, Lijckle
AU  - van der Laan L
AD  - Department of Surgery, Amphia Hospital, Breda, The Netherlands.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20141128
PL  - Netherlands
TA  - Ann Vasc Surg
JT  - Annals of vascular surgery
JID - 8703941
RN  - 0 (Fibrinolytic Agents)
SB  - IM
MH  - Acute Disease
MH  - Aged
MH  - Aged, 80 and over
MH  - Databases, Factual
MH  - Embolectomy/*adverse effects/mortality
MH  - Extremities/*blood supply
MH  - Female
MH  - Fibrinolytic Agents/administration & dosage/*adverse effects
MH  - Humans
MH  - Ischemia/diagnosis/mortality/physiopathology/*therapy
MH  - Kaplan-Meier Estimate
MH  - Limb Salvage
MH  - Male
MH  - Middle Aged
MH  - Postoperative Complications/*etiology/mortality
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Thrombectomy/*adverse effects/mortality
MH  - Thrombolytic Therapy/*adverse effects/mortality
MH  - Time Factors
MH  - Treatment Outcome
MH  - Vascular Patency/drug effects
EDAT- 2014/12/03 06:00
MHDA- 2015/10/29 06:00
CRDT- 2014/12/03 06:00
PHST- 2014/05/14 00:00 [received]
PHST- 2014/08/19 00:00 [revised]
PHST- 2014/10/05 00:00 [accepted]
PHST- 2014/12/03 06:00 [entrez]
PHST- 2014/12/03 06:00 [pubmed]
PHST- 2015/10/29 06:00 [medline]
AID - S0890-5096(14)00681-5 [pii]
AID - 10.1016/j.avsg.2014.10.022 [doi]
PST - ppublish
SO  - Ann Vasc Surg. 2015 Feb;29(2):293-302. doi: 10.1016/j.avsg.2014.10.022. Epub 2014 
      Nov 28.