PMID- 25452859
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20141202
LR  - 20220408
IS  - 2052-4897 (Print)
IS  - 2052-4897 (Electronic)
IS  - 2052-4897 (Linking)
VI  - 2
IP  - 1
DP  - 2014
TI  - Retinopathy and clinical outcomes in patients with type 2 diabetes mellitus, 
      chronic kidney disease, and anemia.
PG  - e000011
LID - 10.1136/bmjdrc-2013-000011 [doi]
LID - e000011
AB  - OBJECTIVE: Retinopathy is an established microvascular complication of type 2 
      diabetes mellitus (T2DM), but its independent relationship with macrovascular and 
      other microvascular complications is less well defined across the spectrum of 
      kidney disease in T2DM. We examined the prognostic value of retinopathy in 
      assessing the risk of developing end-stage renal disease (ESRD), cardiovascular 
      morbidity or death among patients in the Trial to Reduce cardiovascular Events 
      with Aranesp Therapy (TREAT). DESIGN: TREAT enrolled 4038 patients with T2DM, 
      chronic kidney disease (CKD) and moderate anemia. Patients were grouped by 
      baseline history of retinopathy. Proportional hazards regression models were 
      utilized to assess the association between retinopathy and subsequent ESRD, 
      cardiovascular morbidity or death over an average of 2.4 years. RESULTS: Although 
      younger, the 1895 (47%) patients with retinopathy had longer duration of 
      diabetes, lower estimated glomerular filtration rate, more proteinuria, and more 
      microvascular complications. In univariate analysis, retinopathy was associated 
      with a higher rate of ESRD, but not with cardiovascular events or mortality. 
      After adjustment, retinopathy was no longer statistically significant for the 
      prediction of ESRD or any clinical endpoint. CONCLUSIONS: In a large cohort of 
      patients with T2DM, CKD, and anemia, retinopathy was common but not independently 
      associated with a higher risk of renal or cardiovascular morbidity or death. 
      TRIAL REGISTRATION NUMBER: NCT00093015.
FAU - Bello, Natalie A
AU  - Bello NA
AD  - Cardiovascular Division , Brigham and Women's Hospital , Boston, Massachusetts , 
      USA.
FAU - Pfeffer, Marc A
AU  - Pfeffer MA
AD  - Cardiovascular Division , Brigham and Women's Hospital , Boston, Massachusetts , 
      USA.
FAU - Skali, Hicham
AU  - Skali H
AD  - Cardiovascular Division , Brigham and Women's Hospital , Boston, Massachusetts , 
      USA.
FAU - McGill, Janet B
AU  - McGill JB
AD  - Division of Endocrinology, Metabolism, and Lipid Research , Washington University 
      School of Medicine , St. Louis, Missouri , USA.
FAU - Rossert, Jerome
AU  - Rossert J
AD  - Amgen , Thousand Oaks, California , USA.
FAU - Olson, Kurt A
AU  - Olson KA
AD  - Amgen , Thousand Oaks, California , USA.
FAU - Weinrauch, Larry
AU  - Weinrauch L
AD  - Cardiovascular Division , Brigham and Women's Hospital , Boston, Massachusetts , 
      USA.
FAU - Cooper, Mark E
AU  - Cooper ME
AD  - Baker IDI Heart & Diabetes Institute , Melbourne, Victoria , Australia.
FAU - de Zeeuw, Dick
AU  - de Zeeuw D
AD  - Department of Clinical Pharmacology , University of Groningen, University Medical 
      Center Groningen , The Netherlands.
FAU - Rossing, Peter
AU  - Rossing P
AD  - Steno Diabetes Center , Copenhagen , Denmark ; Health , University of Aarhus , 
      Denmark ; CBMR, University of Copenhagen , Denmark.
FAU - McMurray, John J V
AU  - McMurray JJ
AD  - BHF Glasgow Cardiovascular Research Centre , University of Glasgow , Glasgow , 
      UK.
FAU - Solomon, Scott D
AU  - Solomon SD
AD  - Cardiovascular Division , Brigham and Women's Hospital , Boston, Massachusetts , 
      USA.
LA  - eng
SI  - ClinicalTrials.gov/NCT00093015
GR  - T32 HL007374/HL/NHLBI NIH HHS/United States
PT  - Journal Article
DEP - 20140406
PL  - England
TA  - BMJ Open Diabetes Res Care
JT  - BMJ open diabetes research & care
JID - 101641391
PMC - PMC4212578
OTO - NOTNLM
OT  - Cardiovascular Outcomes
OT  - Chronic Kidney Disease
OT  - Retinopathy
OT  - Type 2 Diabetes
EDAT- 2014/12/03 06:00
MHDA- 2014/12/03 06:01
PMCR- 2014/04/06
CRDT- 2014/12/03 06:00
PHST- 2013/12/12 00:00 [received]
PHST- 2014/02/10 00:00 [revised]
PHST- 2014/02/13 00:00 [accepted]
PHST- 2014/12/03 06:00 [entrez]
PHST- 2014/12/03 06:00 [pubmed]
PHST- 2014/12/03 06:01 [medline]
PHST- 2014/04/06 00:00 [pmc-release]
AID - bmjdrc-2013-000011 [pii]
AID - 10.1136/bmjdrc-2013-000011 [doi]
PST - epublish
SO  - BMJ Open Diabetes Res Care. 2014 Apr 6;2(1):e000011. doi: 
      10.1136/bmjdrc-2013-000011. eCollection 2014.