PMID- 25452912
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20141202
LR  - 20240509
IS  - 2225-319X (Print)
IS  - 2304-1021 (Electronic)
IS  - 2225-319X (Linking)
VI  - 3
IP  - 5
DP  - 2014 Sep
TI  - Mechanical circulatory support in pediatrics.
PG  - 507-12
LID - 10.3978/j.issn.2225-319X.2014.08.25 [doi]
AB  - There is no reliable published data on the overall prevalence or incidence of 
      heart failure (HF) in children. However, the success of mechanical circulatory 
      support (MCS) in management of HF has raised the prospect of a previously 
      unavailable treatment modality. Orthotopic heart transplant (OHTx) remains the 
      gold standard treatment, but the number of patients requiring this treatment far 
      outweighs the donor availability. It is therefore not surprising to see the 
      popularity of various MCS modalities, with different devices ranging from 
      veno-arterial extra corporeal membrane oxygenation (VA-ECMO) to ventricular 
      assist devices (VADs), which are either para-corporeal or intra-corporeal, with 
      pulsatile or continuous flow. Indication, timing and the choice of the type of 
      mechanical support are crucial so in order to avoid potential lethal 
      complications such as hemorrhage, thrombo-embolism and infections. In the 
      pediatric population, MCS is used mainly as bridge to transplantation but can be 
      used as bridge to recovery in patients with acute myocarditis or following 
      open-heart surgery. Active research is currently underway to develop newer and 
      more durable devices that will assist the pediatric population across all age 
      groups. This research will support different pathologies that have lower 
      incidences of major morbidities, particularly as greater durations of MCS are 
      expected due to a paucity of donors for OHTx. The combined experience developed 
      through the usage of different devices in pediatric and adult populations has led 
      to the to the application of MCS in some subgroups of grown-up congenital heart 
      diseases (CHDs) patients, particularly those with systemic right ventricular 
      failure.
FAU - Gandolfo, Fabrizio
AU  - Gandolfo F
AD  - Freeman Hospital, Newcastle Upon Tyne, NE7 7DN, UK.
FAU - De Rita, Fabrizio
AU  - De Rita F
AD  - Freeman Hospital, Newcastle Upon Tyne, NE7 7DN, UK.
FAU - Hasan, Asif
AU  - Hasan A
AD  - Freeman Hospital, Newcastle Upon Tyne, NE7 7DN, UK.
FAU - Griselli, Massimo
AU  - Griselli M
AD  - Freeman Hospital, Newcastle Upon Tyne, NE7 7DN, UK.
LA  - eng
PT  - Journal Article
PL  - China
TA  - Ann Cardiothorac Surg
JT  - Annals of cardiothoracic surgery
JID - 101605877
PMC - PMC4229474
OTO - NOTNLM
OT  - Pediatric heart failure
OT  - congenital
OT  - extra corporeal membrane oxygenator (ECMO)
OT  - heart transplantation
OT  - mechanical circulatory support (MCS)
OT  - ventricular assist devices (VADs)
EDAT- 2014/12/03 06:00
MHDA- 2014/12/03 06:01
PMCR- 2014/09/01
CRDT- 2014/12/03 06:00
PHST- 2014/05/24 00:00 [received]
PHST- 2014/08/25 00:00 [accepted]
PHST- 2014/12/03 06:00 [entrez]
PHST- 2014/12/03 06:00 [pubmed]
PHST- 2014/12/03 06:01 [medline]
PHST- 2014/09/01 00:00 [pmc-release]
AID - acs-03-05-507 [pii]
AID - 10.3978/j.issn.2225-319X.2014.08.25 [doi]
PST - ppublish
SO  - Ann Cardiothorac Surg. 2014 Sep;3(5):507-12. doi: 
      10.3978/j.issn.2225-319X.2014.08.25.