PMID- 25453366
OWN - NLM
STAT- MEDLINE
DCOM- 20150212
LR  - 20220331
IS  - 0006-3002 (Print)
IS  - 0006-3002 (Linking)
VI  - 1846
IP  - 2
DP  - 2014 Dec
TI  - Human leukocyte antigen (HLA)-G and cervical cancer immunoediting: a candidate 
      molecule for therapeutic intervention and prognostic biomarker?
PG  - 576-89
LID - S0304-419X(14)00093-6 [pii]
LID - 10.1016/j.bbcan.2014.10.004 [doi]
AB  - While persistent infection with oncogenic types of human Papillomavirus (HPV) is 
      required for cervical epithelial cell transformation and cervical carcinogenesis, 
      HPV infection alone is not sufficient to induce tumorigenesis. Only a minor 
      fraction of HPV infections produce high-grade lesions and cervical cancer, 
      suggesting complex host-virus interactions. Based on its pronounced 
      immunoinhibitory properties, human leukocyte antigen (HLA)-G has been proposed as 
      a possible prognostic biomarker and therapeutic target relevant in a wide variety 
      of cancers and viral infections, but to date remains underexplored in cervical 
      cancer. Given the possible influence of HLA-G on the clinical course of HPV 
      infection, cervical lesions and cancer progression, a better understanding of 
      HLA-G involvement in cervical carcinogenesis might contribute to two aspects of 
      fundamental importance: 1. Characterization of a novel diagnostic/prognostic 
      biomarker to identify cervical cancer and to monitor disease stage, critical for 
      patient screening; 2. Identification of HLA-G-driven immune mechanisms involved 
      in lesion development and cancer progression, leading to the development of 
      strategies for modulating HLA-G expression for treatment purposes. Thus, this 
      systematic review explores the potential involvement of HLA-G protein expression 
      and polymorphisms in cervical carcinogenesis.
CI  - Copyright (c) 2014 Elsevier B.V. All rights reserved.
FAU - Gimenes, Fabricia
AU  - Gimenes F
AD  - Laboratory of Clinical Cytology, Department of Clinical Analysis and Biomedicine, 
      State University of Maringa, 87020900 Parana, Brazil.
FAU - Teixeira, Jorge Juarez Vieira
AU  - Teixeira JJ
AD  - Laboratory of Clinical Cytology, Department of Clinical Analysis and Biomedicine, 
      State University of Maringa, 87020900 Parana, Brazil.
FAU - de Abreu, Andre Luelsdorf Pimenta
AU  - de Abreu AL
AD  - Laboratory of Clinical Cytology, Department of Clinical Analysis and Biomedicine, 
      State University of Maringa, 87020900 Parana, Brazil.
FAU - Souza, Raquel Pantarotto
AU  - Souza RP
AD  - Laboratory of Clinical Cytology, Department of Clinical Analysis and Biomedicine, 
      State University of Maringa, 87020900 Parana, Brazil.
FAU - Pereira, Monalisa Wolski
AU  - Pereira MW
AD  - Laboratory of Clinical Cytology, Department of Clinical Analysis and Biomedicine, 
      State University of Maringa, 87020900 Parana, Brazil.
FAU - da Silva, Vania Ramos Sela
AU  - da Silva VR
AD  - Laboratory of Clinical Cytology, Department of Clinical Analysis and Biomedicine, 
      State University of Maringa, 87020900 Parana, Brazil.
FAU - Boer, Cinthia Gandolfi
AU  - Boer CG
AD  - Laboratory of Clinical Cytology, Department of Clinical Analysis and Biomedicine, 
      State University of Maringa, 87020900 Parana, Brazil.
FAU - Maria-Engler, Silvya Stuchi
AU  - Maria-Engler SS
AD  - Clinical Chemistry and Toxicology Department, School of Pharmaceutical Sciences, 
      University of Sao Paulo, 05508000 Sao Paulo, Brazil.
FAU - Bonini, Marcelo Gialluisi
AU  - Bonini MG
AD  - College of Medicine, Departments of Medicine, Pharmacology and Pathology, 
      University of Illinois at Chicago, 60612 Chicago, IL, USA.
FAU - Borelli, Sueli Donizete
AU  - Borelli SD
AD  - Laboratory of Immunogenetics, Department of Basic Health Sciences, State 
      University of Maringa, 87020900 Parana, Brazil.
FAU - Consolaro, Marcia Edilaine Lopes
AU  - Consolaro ME
AD  - Laboratory of Clinical Cytology, Department of Clinical Analysis and Biomedicine, 
      State University of Maringa, 87020900 Parana, Brazil. Electronic address: 
      melconsolaro@gmail.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PT  - Systematic Review
DEP - 20141023
PL  - Netherlands
TA  - Biochim Biophys Acta
JT  - Biochimica et biophysica acta
JID - 0217513
RN  - 0 (HLA-G Antigens)
SB  - IM
MH  - Female
MH  - HLA-G Antigens/genetics/*physiology
MH  - Humans
MH  - Polymorphism, Genetic
MH  - Prognosis
MH  - Uterine Cervical Neoplasms/etiology/*immunology/therapy
OTO - NOTNLM
OT  - Cancer immunoediting
OT  - Cervical cancer
OT  - HLA-G
OT  - HPV
OT  - Prognostic biomarker
OT  - Therapeutic intervention
EDAT- 2014/12/03 06:00
MHDA- 2015/02/13 06:00
CRDT- 2014/12/03 06:00
PHST- 2014/06/17 00:00 [received]
PHST- 2014/10/14 00:00 [revised]
PHST- 2014/10/14 00:00 [accepted]
PHST- 2014/12/03 06:00 [entrez]
PHST- 2014/12/03 06:00 [pubmed]
PHST- 2015/02/13 06:00 [medline]
AID - S0304-419X(14)00093-6 [pii]
AID - 10.1016/j.bbcan.2014.10.004 [doi]
PST - ppublish
SO  - Biochim Biophys Acta. 2014 Dec;1846(2):576-89. doi: 10.1016/j.bbcan.2014.10.004. 
      Epub 2014 Oct 23.