PMID- 25454223
OWN - NLM
STAT- MEDLINE
DCOM- 20150708
LR  - 20190110
IS  - 1873-6750 (Electronic)
IS  - 0160-4120 (Linking)
VI  - 74
DP  - 2015 Jan
TI  - Historical intake and elimination of polychlorinated biphenyls and organochlorine 
      pesticides by the Australian population reconstructed from biomonitoring data.
PG  - 82-8
LID - S0160-4120(14)00290-6 [pii]
LID - 10.1016/j.envint.2014.09.014 [doi]
AB  - Quantifying the competing rates of intake and elimination of persistent organic 
      pollutants (POPs) in the human body is necessary to understand the levels and 
      trends of POPs at a population level. In this paper we reconstruct the historical 
      intake and elimination of ten polychlorinated biphenyls (PCBs) and five 
      organochlorine pesticides (OCPs) from Australian biomonitoring data by fitting a 
      population-level pharmacokinetic (PK) model. Our analysis exploits two sets of 
      cross-sectional biomonitoring data for PCBs and OCPs in pooled blood serum 
      samples from the Australian population that were collected in 2003 and 2009. The 
      modeled adult reference intakes in 1975 for PCB congeners ranged from 0.89 to 
      24.5ng/kgbw/day, lower than the daily intakes of OCPs ranging from 73 to 
      970ng/kgbw/day. Modeled intake rates are declining with half-times from 1.1 to 
      1.3years for PCB congeners and 0.83 to 0.97years for OCPs. The shortest modeled 
      intrinsic human elimination half-life among the compounds studied here is 
      6.4years for hexachlorobenzene, and the longest is 30years for PCB-74. Our 
      results indicate that it is feasible to reconstruct intakes and to estimate 
      intrinsic human elimination half-lives using the population-level PK model and 
      biomonitoring data only. Our modeled intrinsic human elimination half-lives are 
      in good agreement with values from a similar study carried out for the population 
      of the United Kingdom, and are generally longer than reported values from other 
      industrialized countries in the Northern Hemisphere.
CI  - Copyright (c) 2014. Published by Elsevier Ltd.
FAU - Bu, Qingwei
AU  - Bu Q
AD  - School of Environment, Tsinghua University, Beijing 10085, China; School of 
      Chemical & Environmental Engineering, China University of Mining and Technology 
      (Beijing), Beijing 100083, China.
FAU - MacLeod, Matthew
AU  - MacLeod M
AD  - Department of Applied Environmental Science (ITM), Stockholm University, SE-106 
      91 Stockholm, Sweden. Electronic address: matthew.macleod@itm.su.se.
FAU - Wong, Fiona
AU  - Wong F
AD  - Department of Applied Environmental Science (ITM), Stockholm University, SE-106 
      91 Stockholm, Sweden.
FAU - Toms, Leisa-Maree L
AU  - Toms LM
AD  - School of Clinical Sciences and Institute of Health and Biomedical Innovation, 
      Faculty of Health, Queensland University of Technology, Brisbane, Australia.
FAU - Mueller, Jochen F
AU  - Mueller JF
AD  - The University of Queensland, Entox, 39 Kessels Road, Coopers Plains, Australia.
FAU - Yu, Gang
AU  - Yu G
AD  - School of Environment, Tsinghua University, Beijing 10085, China. Electronic 
      address: yg-den@tsinghua.edu.cn.
LA  - eng
PT  - Historical Article
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141021
PL  - Netherlands
TA  - Environ Int
JT  - Environment international
JID - 7807270
RN  - 0 (Environmental Pollutants)
RN  - 0 (Hydrocarbons, Chlorinated)
RN  - 0 (Pesticides)
RN  - 4Z87H0LKUY (Hexachlorobenzene)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
RN  - W0250484DW (2,4,4',5-tetrachlorobiphenyl)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Australia
MH  - Child
MH  - Child, Preschool
MH  - Cross-Sectional Studies
MH  - Environmental Monitoring
MH  - Environmental Pollutants/*analysis/history/pharmacokinetics
MH  - Female
MH  - Half-Life
MH  - Hexachlorobenzene/analysis/pharmacokinetics
MH  - History, 20th Century
MH  - Humans
MH  - Hydrocarbons, Chlorinated/*analysis/history/pharmacokinetics
MH  - Infant
MH  - Infant, Newborn
MH  - Male
MH  - Middle Aged
MH  - Models, Theoretical
MH  - Pesticides/*analysis/history/pharmacokinetics
MH  - Polychlorinated Biphenyls/*analysis/history/pharmacokinetics
MH  - Young Adult
OTO - NOTNLM
OT  - Elimination
OT  - Intake
OT  - Modeling
OT  - OCPs
OT  - PCBs
OT  - Pharmacokinetics
EDAT- 2014/12/03 06:00
MHDA- 2015/07/15 06:00
CRDT- 2014/12/03 06:00
PHST- 2014/04/08 00:00 [received]
PHST- 2014/07/30 00:00 [revised]
PHST- 2014/09/26 00:00 [accepted]
PHST- 2014/12/03 06:00 [entrez]
PHST- 2014/12/03 06:00 [pubmed]
PHST- 2015/07/15 06:00 [medline]
AID - S0160-4120(14)00290-6 [pii]
AID - 10.1016/j.envint.2014.09.014 [doi]
PST - ppublish
SO  - Environ Int. 2015 Jan;74:82-8. doi: 10.1016/j.envint.2014.09.014. Epub 2014 Oct 
      21.