PMID- 25454277
OWN - NLM
STAT- MEDLINE
DCOM- 20150901
LR  - 20181202
IS  - 1872-8952 (Electronic)
IS  - 1388-2457 (Linking)
VI  - 126
IP  - 7
DP  - 2015 Jul
TI  - Different responses to facilitatory rTMS according to BDNF genotype.
PG  - 1348-53
LID - S1388-2457(14)00533-1 [pii]
LID - 10.1016/j.clinph.2014.09.028 [doi]
AB  - OBJECTIVE: To investigate whether there is a relation between the plasticity 
      induced by different intensities of facilitatory rTMS with different intensities 
      and brain-derived neurotrophic factor (BDNF) genotype. METHODS: Forty healthy 
      volunteers (14 men, mean age 27.3years) were enrolled. All participants received 
      three high-frequency rTMS applications in random order over the non-dominant 
      primary motor cortex with more than a 24-h washout period: 1st condition, rTMS 
      with sub-threshold intensity; 2nd condition, rTMS with supra-threshold intensity; 
      and 3rd condition, sham rTMS. Cortical excitability was assessed before and after 
      rTMS using motor-evoked potentials (MEPs). Data were analyzed using the BDNF 
      genotype. RESULTS: Twelve, 19, and 9 participants were classified into Val/Val, 
      Val/Met, and Met/Met groups, respectively. In each group, there were significant 
      increases in the amplitude of MEPs after 1st and 2nd conditions (P<0.05), but not 
      after 3rd condition. In Val/Val group, the increase ratio of MEPs' amplitude 
      after 2nd condition was significantly higher than 1st condition (P<0.05). 
      However, no significant amplitude differences in Val/Met and Met/Met groups were 
      observed after 1st and 2nd conditions. CONCLUSIONS: High-frequency rTMS induces 
      the facilitation of cortical excitability regardless of BDNF genotype. BDNF 
      genotype might influence on different responses of plasticity based on the rTMS 
      intensity. SIGNIFICANCE: BDNF genotype is one of influence factors on the 
      plasticity after the facilitatory rTMS.
CI  - Copyright (c) 2014 International Federation of Clinical Neurophysiology. Published 
      by Elsevier Ireland Ltd. All rights reserved.
FAU - Hwang, Jung Min
AU  - Hwang JM
AD  - Department of Physical and Rehabilitation Medicine, Center for Prevention and 
      Rehabilitation, Heart Vascular and Stroke Institute, Samsung Medical Center, 
      Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
FAU - Kim, Yun-Hee
AU  - Kim YH
AD  - Department of Physical and Rehabilitation Medicine, Center for Prevention and 
      Rehabilitation, Heart Vascular and Stroke Institute, Samsung Medical Center, 
      Sungkyunkwan University School of Medicine, Seoul, Republic of Korea; Samsung 
      Advanced Institute for Health Science and Technology, Sungkyunkwan University, 
      Seoul, Republic of Korea.
FAU - Yoon, Kyung Jae
AU  - Yoon KJ
AD  - Department of Physical and Rehabilitation Medicine, Kangbuk Samsung Hospital, 
      Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
FAU - Uhm, Kyeong Eun
AU  - Uhm KE
AD  - Department of Physical and Rehabilitation Medicine, Center for Prevention and 
      Rehabilitation, Heart Vascular and Stroke Institute, Samsung Medical Center, 
      Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
FAU - Chang, Won Hyuk
AU  - Chang WH
AD  - Department of Physical and Rehabilitation Medicine, Center for Prevention and 
      Rehabilitation, Heart Vascular and Stroke Institute, Samsung Medical Center, 
      Sungkyunkwan University School of Medicine, Seoul, Republic of Korea. Electronic 
      address: wh.chang@samsung.com.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141012
PL  - Netherlands
TA  - Clin Neurophysiol
JT  - Clinical neurophysiology : official journal of the International Federation of 
      Clinical Neurophysiology
JID - 100883319
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
CIN - Clin Neurophysiol. 2015 Jul;126(7):1281-3. PMID: 25454276
MH  - Adult
MH  - Anxiety/epidemiology/etiology
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Evoked Potentials, Motor/*physiology
MH  - Female
MH  - Genotype
MH  - Headache/epidemiology/etiology
MH  - Humans
MH  - Incidence
MH  - Male
MH  - Motor Cortex/*physiology
MH  - Neuronal Plasticity/physiology
MH  - Polymorphism, Genetic/genetics
MH  - Transcranial Magnetic Stimulation/adverse effects/*methods
OTO - NOTNLM
OT  - BDNF
OT  - Cortical excitability
OT  - Motor-evoked potentials
OT  - Polymorphism
OT  - rTMS
EDAT- 2014/12/03 06:00
MHDA- 2015/09/02 06:00
CRDT- 2014/12/03 06:00
PHST- 2014/04/06 00:00 [received]
PHST- 2014/09/04 00:00 [revised]
PHST- 2014/09/06 00:00 [accepted]
PHST- 2014/12/03 06:00 [entrez]
PHST- 2014/12/03 06:00 [pubmed]
PHST- 2015/09/02 06:00 [medline]
AID - S1388-2457(14)00533-1 [pii]
AID - 10.1016/j.clinph.2014.09.028 [doi]
PST - ppublish
SO  - Clin Neurophysiol. 2015 Jul;126(7):1348-53. doi: 10.1016/j.clinph.2014.09.028. 
      Epub 2014 Oct 12.