PMID- 25454591
OWN - NLM
STAT- MEDLINE
DCOM- 20150727
LR  - 20220309
IS  - 1879-0445 (Electronic)
IS  - 0960-9822 (Print)
IS  - 0960-9822 (Linking)
VI  - 24
IP  - 23
DP  - 2014 Dec 1
TI  - CREB regulates memory allocation in the insular cortex.
PG  - 2833-7
LID - S0960-9822(14)01294-9 [pii]
LID - 10.1016/j.cub.2014.10.018 [doi]
AB  - The molecular and cellular mechanisms of memory storage have attracted a great 
      deal of attention. By comparison, little is known about memory allocation, the 
      process that determines which specific neurons in a neural network will store a 
      given memory. Previous studies demonstrated that memory allocation is not random 
      in the amygdala; these studies showed that amygdala neurons with higher levels of 
      the cyclic-AMP-response-element-binding protein (CREB) are more likely to be 
      recruited into encoding and storing fear memory. To determine whether specific 
      mechanisms also regulate memory allocation in other brain regions and whether 
      CREB also has a role in this process, we studied insular cortical memory 
      representations for conditioned taste aversion (CTA). In this task, an animal 
      learns to associate a taste (conditioned stimulus [CS]) with the experience of 
      malaise (such as that induced by LiCl; unconditioned stimulus [US]). The insular 
      cortex is required for CTA memory formation and retrieval. CTA learning activates 
      a subpopulation of neurons in this structure, and the insular cortex and the 
      basolateral amygdala (BLA) interact during CTA formation. Here, we used a 
      combination of approaches, including viral vector transfections of insular 
      cortex, arc fluorescence in situ hybridization (FISH), and designer receptors 
      exclusively activated by designer drugs (DREADD) system, to show that CREB levels 
      determine which insular cortical neurons go on to encode a given conditioned 
      taste memory.
CI  - Copyright (c) 2014 Elsevier Ltd. All rights reserved.
FAU - Sano, Yoshitake
AU  - Sano Y
AD  - Departments of Neurobiology, Psychiatry and Biobehavioral Sciences, Psychology, 
      Integrative Center for Learning and Memory and Brain Research Institute, 
      University of California, Los Angeles, Los Angeles, CA 90095, USA.
FAU - Shobe, Justin L
AU  - Shobe JL
AD  - Departments of Neurobiology, Psychiatry and Biobehavioral Sciences, Psychology, 
      Integrative Center for Learning and Memory and Brain Research Institute, 
      University of California, Los Angeles, Los Angeles, CA 90095, USA.
FAU - Zhou, Miou
AU  - Zhou M
AD  - Departments of Neurobiology, Psychiatry and Biobehavioral Sciences, Psychology, 
      Integrative Center for Learning and Memory and Brain Research Institute, 
      University of California, Los Angeles, Los Angeles, CA 90095, USA.
FAU - Huang, Shan
AU  - Huang S
AD  - Departments of Neurobiology, Psychiatry and Biobehavioral Sciences, Psychology, 
      Integrative Center for Learning and Memory and Brain Research Institute, 
      University of California, Los Angeles, Los Angeles, CA 90095, USA.
FAU - Shuman, Tristan
AU  - Shuman T
AD  - Department of Neurology at David Geffen School of Medicine, University of 
      California, Los Angeles, Los Angeles, CA 90095, USA.
FAU - Cai, Denise J
AU  - Cai DJ
AD  - Departments of Neurobiology, Psychiatry and Biobehavioral Sciences, Psychology, 
      Integrative Center for Learning and Memory and Brain Research Institute, 
      University of California, Los Angeles, Los Angeles, CA 90095, USA.
FAU - Golshani, Peyman
AU  - Golshani P
AD  - Department of Neurology at David Geffen School of Medicine, University of 
      California, Los Angeles, Los Angeles, CA 90095, USA.
FAU - Kamata, Masakazu
AU  - Kamata M
AD  - Department of Hematology and Oncology, University of California, Los Angeles, Los 
      Angeles, CA 90095, USA.
FAU - Silva, Alcino J
AU  - Silva AJ
AD  - Departments of Neurobiology, Psychiatry and Biobehavioral Sciences, Psychology, 
      Integrative Center for Learning and Memory and Brain Research Institute, 
      University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic 
      address: silvaa@mednet.ucla.edu.
LA  - eng
GR  - R01 AG013622/AG/NIA NIH HHS/United States
GR  - R37 AG013622/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20141113
PL  - England
TA  - Curr Biol
JT  - Current biology : CB
JID - 9107782
RN  - 0 (Creb1 protein, mouse)
RN  - 0 (Cyclic AMP Response Element-Binding Protein)
RN  - G4962QA067 (Lithium Chloride)
SB  - IM
MH  - Animals
MH  - Avoidance Learning/physiology
MH  - Cerebral Cortex/*physiology
MH  - Conditioning, Classical/physiology
MH  - Cyclic AMP Response Element-Binding Protein/*physiology
MH  - Gene Silencing
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Lithium Chloride/pharmacology
MH  - Memory/*physiology
MH  - Mice, Inbred C57BL
MH  - Neurons/physiology
MH  - Taste
PMC - PMC4743759
MID - NIHMS635066
EDAT- 2014/12/03 06:00
MHDA- 2015/07/28 06:00
PMCR- 2016/02/05
CRDT- 2014/12/03 06:00
PHST- 2014/03/23 00:00 [received]
PHST- 2014/09/04 00:00 [revised]
PHST- 2014/10/08 00:00 [accepted]
PHST- 2014/12/03 06:00 [entrez]
PHST- 2014/12/03 06:00 [pubmed]
PHST- 2015/07/28 06:00 [medline]
PHST- 2016/02/05 00:00 [pmc-release]
AID - S0960-9822(14)01294-9 [pii]
AID - 10.1016/j.cub.2014.10.018 [doi]
PST - ppublish
SO  - Curr Biol. 2014 Dec 1;24(23):2833-7. doi: 10.1016/j.cub.2014.10.018. Epub 2014 
      Nov 13.