PMID- 2545485
OWN - NLM
STAT- MEDLINE
DCOM- 19890818
LR  - 20190813
IS  - 0303-7207 (Print)
IS  - 0303-7207 (Linking)
VI  - 62
IP  - 1
DP  - 1989 Mar
TI  - Prolactin regulation of mouse mammary tumor virus (MMTV) expression in normal 
      mouse mammary epithelium.
PG  - 23-9
AB  - The hormonal regulation of mouse mammary tumor virus (MMTV) RNA in normal mouse 
      mammary epithelium was studied in an explant system. In tissue from parous mice, 
      physiological concentrations of prolactin stimulated MMTV expression, while only 
      pharmacological concentrations of cortisol were effective. Regulation in explants 
      from virgin mice was similar to that in parous animals except that the former 
      were less sensitive to prolactin; this relative unresponsiveness may explain why 
      uninduced tissue from virgin mice does not express MMTV RNA, while that from 
      parous mice does exhibit some basal production. These results suggest that 
      prolactin plays a major role in MMTV expression in normal mammary epithelium and 
      that glucocorticoids may only have a permissive effect or may act through an 
      indirect mechanism requiring high concentrations. These data also suggest that 
      the greater susceptibility of parous mice to MMTV-induced tumorigenesis may 
      reflect the greater prolactin sensitivity in the glands from these animals.
FAU - Munoz, B
AU  - Munoz B
AD  - Department of Biology, University of South Carolina, Columbia 29208.
FAU - Bolander, F F Jr
AU  - Bolander FF Jr
LA  - eng
GR  - CA 42009/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Ireland
TA  - Mol Cell Endocrinol
JT  - Molecular and cellular endocrinology
JID - 7500844
RN  - 0 (RNA, Viral)
RN  - 9002-62-4 (Prolactin)
SB  - IM
MH  - Animals
MH  - Dose-Response Relationship, Drug
MH  - Epithelium/analysis/metabolism/microbiology
MH  - Female
MH  - Gene Expression Regulation
MH  - Mammary Glands, Animal/analysis/metabolism/*microbiology
MH  - Mammary Tumor Virus, Mouse/genetics/*physiology
MH  - Mice
MH  - Prolactin/*pharmacology
MH  - RNA, Viral/analysis
MH  - Time Factors
EDAT- 1989/03/01 00:00
MHDA- 2001/03/28 10:01
CRDT- 1989/03/01 00:00
PHST- 1989/03/01 00:00 [pubmed]
PHST- 2001/03/28 10:01 [medline]
PHST- 1989/03/01 00:00 [entrez]
AID - 0303-7207(89)90109-3 [pii]
AID - 10.1016/0303-7207(89)90109-3 [doi]
PST - ppublish
SO  - Mol Cell Endocrinol. 1989 Mar;62(1):23-9. doi: 10.1016/0303-7207(89)90109-3.