PMID- 25455510
OWN - NLM
STAT- MEDLINE
DCOM- 20150804
LR  - 20220419
IS  - 1879-1379 (Electronic)
IS  - 0022-3956 (Print)
IS  - 0022-3956 (Linking)
VI  - 60
DP  - 2015 Jan
TI  - A meta-analytic review of the effects of exercise on brain-derived neurotrophic 
      factor.
PG  - 56-64
LID - S0022-3956(14)00293-3 [pii]
LID - 10.1016/j.jpsychires.2014.10.003 [doi]
AB  - Consistent evidence indicates that exercise improves cognition and mood, with 
      preliminary evidence suggesting that brain-derived neurotrophic factor (BDNF) may 
      mediate these effects. The aim of the current meta-analysis was to provide an 
      estimate of the strength of the association between exercise and increased BDNF 
      levels in humans across multiple exercise paradigms. We conducted a meta-analysis 
      of 29 studies (N = 1111 participants) examining the effect of exercise on BDNF 
      levels in three exercise paradigms: (1) a single session of exercise, (2) a 
      session of exercise following a program of regular exercise, and (3) resting BDNF 
      levels following a program of regular exercise. Moderators of this effect were 
      also examined. Results demonstrated a moderate effect size for increases in BDNF 
      following a single session of exercise (Hedges' g = 0.46, p < 0.001). Further, 
      regular exercise intensified the effect of a session of exercise on BDNF levels 
      (Hedges' g = 0.59, p = 0.02). Finally, results indicated a small effect of 
      regular exercise on resting BDNF levels (Hedges' g = 0.27, p = 0.005). When 
      analyzing results across paradigms, sex significantly moderated the effect of 
      exercise on BDNF levels, such that studies with more women showed less BDNF 
      change resulting from exercise. Effect size analysis supports the role of 
      exercise as a strategy for enhancing BDNF activity in humans, but indicates that 
      the magnitude of these effects may be lower in females relative to males.
CI  - Copyright (c) 2014 Elsevier Ltd. All rights reserved.
FAU - Szuhany, Kristin L
AU  - Szuhany KL
AD  - Department of Psychological and Brain Sciences, Boston University, 648 Beacon 
      St., 5th Floor, Boston, MA 02215, USA. Electronic address: kszuhany@bu.edu.
FAU - Bugatti, Matteo
AU  - Bugatti M
AD  - Department of Psychological and Brain Sciences, Boston University, 648 Beacon 
      St., 5th Floor, Boston, MA 02215, USA.
FAU - Otto, Michael W
AU  - Otto MW
AD  - Department of Psychological and Brain Sciences, Boston University, 648 Beacon 
      St., 5th Floor, Boston, MA 02215, USA.
LA  - eng
GR  - F31 MH100773/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, N.I.H., Extramural
PT  - Review
DEP - 20141012
PL  - England
TA  - J Psychiatr Res
JT  - Journal of psychiatric research
JID - 0376331
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Exercise/*physiology/*psychology
MH  - Female
MH  - Humans
MH  - Male
MH  - Motor Activity/*physiology
MH  - Sex Factors
MH  - Time Factors
PMC - PMC4314337
MID - NIHMS644150
OTO - NOTNLM
OT  - BDNF
OT  - Brain-derived neurotrophic factor
OT  - Exercise
OT  - Meta-analysis
OT  - Physical activity
COIS- Conflict of Interest In the past 3 years Dr. Otto has served as a paid consultant 
      for MicroTransponder Inc., Concert Pharmaceuticals, and ProPhase; provided expert 
      consensus opinion for Otsuka Pharmaceuticals; received royalty support for use of 
      the SIGH-A from ProPhase; and received book royalties from Oxford University 
      Press, Routledge, and Springer. The other authors have no conflicts to report.
EDAT- 2014/12/03 06:00
MHDA- 2015/08/05 06:00
PMCR- 2016/01/01
CRDT- 2014/12/03 06:00
PHST- 2014/05/12 00:00 [received]
PHST- 2014/09/29 00:00 [revised]
PHST- 2014/10/04 00:00 [accepted]
PHST- 2014/12/03 06:00 [entrez]
PHST- 2014/12/03 06:00 [pubmed]
PHST- 2015/08/05 06:00 [medline]
PHST- 2016/01/01 00:00 [pmc-release]
AID - S0022-3956(14)00293-3 [pii]
AID - 10.1016/j.jpsychires.2014.10.003 [doi]
PST - ppublish
SO  - J Psychiatr Res. 2015 Jan;60:56-64. doi: 10.1016/j.jpsychires.2014.10.003. Epub 
      2014 Oct 12.