PMID- 25456006
OWN - NLM
STAT- MEDLINE
DCOM- 20150827
LR  - 20220309
IS  - 1879-0593 (Electronic)
IS  - 1368-8375 (Print)
IS  - 1368-8375 (Linking)
VI  - 51
IP  - 1
DP  - 2015 Jan
TI  - Perineural growth in head and neck squamous cell carcinoma: a review.
PG  - 16-23
LID - S1368-8375(14)00299-1 [pii]
LID - 10.1016/j.oraloncology.2014.10.004 [doi]
AB  - Perineural growth is a unique route of tumor metastasis that is associated with 
      poor prognosis in several solid malignancies. It is diagnosed by the presence of 
      tumor cells inside the neural space seen on histological or imaging evaluations. 
      Little is known about molecular mechanisms involved in the growth and spread of 
      tumor cells in neural spaces. The poor prognosis associated with perineural 
      growth and lack of targeted approaches necessitates the study of molecular 
      factors involved in communication between tumor and neural cells. Perineural 
      growth rates, shown to be as high as 63% in head and neck squamous cell carcinoma 
      (HNSCC), correlate with increased local recurrence and decreased disease-free 
      survival. Here we describe the literature on perineural growth in HNSCC. In 
      addition, we discuss factors implicated in perineural growth of cancer. These 
      factors include brain-derived neurotrophic factor (BDNF), nerve growth factor 
      (NGF), neurotrophin-3 and -4, glial cell-line derived neurotrophic factor (GDNF), 
      the neural cell adhesion molecule (NCAM), substance P (SP), and chemokines. We 
      also explore the literature on membrane receptors, including the Trk family and 
      the low-affinity nerve growth factor receptor. This review highlights areas for 
      further study of the mechanisms of perineural invasion which may facilitate the 
      identification of therapeutic targets in HNSCC.
CI  - Copyright (c) 2014 Elsevier Ltd. All rights reserved.
FAU - Roh, Joseph
AU  - Roh J
AD  - Departments of Otolaryngology, University of Kansas Medical Center and University 
      of Kansas Cancer Center, KS, United States.
FAU - Muelleman, Thomas
AU  - Muelleman T
AD  - Departments of Otolaryngology, University of Kansas Medical Center and University 
      of Kansas Cancer Center, KS, United States.
FAU - Tawfik, Ossama
AU  - Tawfik O
AD  - Pathology and Laboratory Medicine, University of Kansas Medical Center and 
      University of Kansas Cancer Center, KS, United States.
FAU - Thomas, Sufi M
AU  - Thomas SM
AD  - Departments of Otolaryngology, University of Kansas Medical Center and University 
      of Kansas Cancer Center, KS, United States; Cancer Biology, University of Kansas 
      Medical Center and University of Kansas Cancer Center, KS, United States; Anatomy 
      and Cell Biology, University of Kansas Medical Center and University of Kansas 
      Cancer Center, KS, United States. Electronic address: sthomas7@kumc.edu.
LA  - eng
GR  - P30 HD002528/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
DEP - 20141025
PL  - England
TA  - Oral Oncol
JT  - Oral oncology
JID - 9709118
SB  - IM
MH  - Carcinoma, Squamous Cell/*pathology
MH  - Head and Neck Neoplasms/*pathology
MH  - Humans
MH  - Neoplasm Metastasis
PMC - PMC4268058
MID - NIHMS637792
OTO - NOTNLM
OT  - Chemokines
OT  - Neurotrophic factors
OT  - Neurotrophin
OT  - Perineural growth
OT  - Perineural invasion
OT  - Squamous cell carcinoma
EDAT- 2014/12/03 06:00
MHDA- 2015/08/28 06:00
PMCR- 2016/01/01
CRDT- 2014/12/03 06:00
PHST- 2014/06/18 00:00 [received]
PHST- 2014/09/30 00:00 [revised]
PHST- 2014/10/06 00:00 [accepted]
PHST- 2014/12/03 06:00 [entrez]
PHST- 2014/12/03 06:00 [pubmed]
PHST- 2015/08/28 06:00 [medline]
PHST- 2016/01/01 00:00 [pmc-release]
AID - S1368-8375(14)00299-1 [pii]
AID - 10.1016/j.oraloncology.2014.10.004 [doi]
PST - ppublish
SO  - Oral Oncol. 2015 Jan;51(1):16-23. doi: 10.1016/j.oraloncology.2014.10.004. Epub 
      2014 Oct 25.