PMID- 25456744
OWN - NLM
STAT- MEDLINE
DCOM- 20150716
LR  - 20220331
IS  - 1096-7206 (Electronic)
IS  - 1096-7192 (Linking)
VI  - 113
IP  - 4
DP  - 2014 Dec
TI  - Homocysteine and DNA methylation: a review of animal and human literature.
PG  - 243-52
LID - S1096-7192(14)00315-1 [pii]
LID - 10.1016/j.ymgme.2014.10.006 [doi]
AB  - Homocysteine (Hcy) is a sulfur-containing non-protein forming amino acid, which 
      is synthesized from methionine as an important intermediate in the one-carbon 
      pathway. High concentrations of Hcy in a condition called hyperhomocysteinemia 
      (HHcy) are an independent risk factor for several disorders including 
      cardiovascular diseases and osteoporotic fractures. Since Hcy is produced as a 
      byproduct of the methyltransferase reaction, alteration in DNA methylation is 
      studied as one of the underlying mechanisms of HHcy-associated disorders. In 
      animal models, elevated Hcy concentrations are induced either by diet (high 
      methionine, low B-vitamins, or both), gene knockouts (Mthfr, Cbs, Mtrr or Mtr) or 
      combination of both to investigate their effects on DNA methylation or its 
      markers. In humans, most of the literature involves case-control studies 
      concerning patients. The focus of this review is to study existing literature on 
      HHcy and its role in relation to DNA methylation. Apart from this, a few studies 
      investigated the effect of Hcy-lowering trials on restoring DNA methylation 
      patterns, by giving a folic acid or B-vitamin supplemented diet. These studies 
      which were conducted in animal models as well as humans were included in this 
      review.
CI  - Copyright (c) 2014 Elsevier Inc. All rights reserved.
FAU - Mandaviya, Pooja R
AU  - Mandaviya PR
AD  - Department of Clinical Chemistry, Erasmus University Medical Center, Rotterdam, 
      The Netherlands; Department of Internal Medicine, Erasmus University Medical 
      Center, Rotterdam, The Netherlands. Electronic address: p.mandaviya@erasmusmc.nl.
FAU - Stolk, Lisette
AU  - Stolk L
AD  - Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, 
      The Netherlands. Electronic address: l.stolk@erasmusmc.nl.
FAU - Heil, Sandra G
AU  - Heil SG
AD  - Department of Clinical Chemistry, Erasmus University Medical Center, Rotterdam, 
      The Netherlands. Electronic address: s.heil@erasmusmc.nl.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20141014
PL  - United States
TA  - Mol Genet Metab
JT  - Molecular genetics and metabolism
JID - 9805456
RN  - 0LVT1QZ0BA (Homocysteine)
RN  - 12001-76-2 (Vitamin B Complex)
RN  - 935E97BOY8 (Folic Acid)
RN  - AE28F7PNPL (Methionine)
RN  - Homocysteinemia
SB  - IM
MH  - Animals
MH  - Case-Control Studies
MH  - *DNA Methylation
MH  - Diet
MH  - Dietary Supplements
MH  - Female
MH  - Folic Acid/administration & dosage/blood
MH  - Gene Knockout Techniques
MH  - Homocysteine/*metabolism
MH  - Humans
MH  - Hyperhomocysteinemia/therapy
MH  - Male
MH  - Methionine/metabolism
MH  - *Models, Animal
MH  - Vitamin B Complex/metabolism/therapeutic use
MH  - Vitamin B Deficiency/diet therapy
OTO - NOTNLM
OT  - B-Vitamins
OT  - DNA methylation
OT  - Homocysteine
OT  - Hyperhomocysteinemia
OT  - S-Adenosylhomocysteine
OT  - S-Adenosylmethionine
EDAT- 2014/12/03 06:00
MHDA- 2015/07/17 06:00
CRDT- 2014/12/03 06:00
PHST- 2014/08/05 00:00 [received]
PHST- 2014/10/04 00:00 [revised]
PHST- 2014/10/04 00:00 [accepted]
PHST- 2014/12/03 06:00 [entrez]
PHST- 2014/12/03 06:00 [pubmed]
PHST- 2015/07/17 06:00 [medline]
AID - S1096-7192(14)00315-1 [pii]
AID - 10.1016/j.ymgme.2014.10.006 [doi]
PST - ppublish
SO  - Mol Genet Metab. 2014 Dec;113(4):243-52. doi: 10.1016/j.ymgme.2014.10.006. Epub 
      2014 Oct 14.