PMID- 25458101
OWN - NLM
STAT- MEDLINE
DCOM- 20150831
LR  - 20191210
IS  - 1532-2688 (Electronic)
IS  - 1059-1311 (Linking)
VI  - 24
DP  - 2015 Jan
TI  - Adult nonconvulsive status epilepticus in a clinical setting: Semiology, 
      aetiology, treatment and outcome.
PG  - 102-6
LID - S1059-1311(14)00258-1 [pii]
LID - 10.1016/j.seizure.2014.09.007 [doi]
AB  - PURPOSE: Our objective was to study the semiology, aetiology, treatment and 
      outcome of nonconvulsive status epilepticus (NCSE) in adults. METHODS: All NCSE 
      episodes in an unselected hospital cohort in the period 2004-2009 were 
      identified, and the files reviewed. STESS (Status Epilepticus Severity Scale) was 
      conducted retrospectively and correlated to outcome. Follow-up was undertaken 
      after >2 years. RESULTS: 48 NCSEs in 39 patients, 22 men and 17 women, were 
      found. Mean age was 63 years. 23/39 (59%) patients had established epilepsy. The 
      underlying cause of NCSE was cerebrovascular disease in 17/39 (44%). 37/48 (77%) 
      NCSEs were complex focal status epilepticus. 3/48 NCSEs (6.3%) lead to death, 
      whereas 8.5% lead to severe sequelae. Cognitive sequelae were found after 14.9% 
      of NCSEs. The outcome was worst in the group with no prior epilepsy (p=0.013). 
      STESS had a negative predictive value of 96% (cut-off value of 3) for severe 
      sequelae and death combined (p<0.002). CONCLUSIONS: NCSE has a potential for 
      severe sequelae and represents an emergency in need of intensive treatment. The 
      major determinant of outcome is the underlying cause. The outcome was worse in 
      patients without epilepsy than in patients with epilepsy. STESS is of value in 
      predicting outcome. Cognitive sequelae following NCSE can occur, but need further 
      investigation with prospective, systematic studies.
CI  - Copyright (c) 2014 British Epilepsy Association. Published by Elsevier Ltd. All 
      rights reserved.
FAU - Power, Kjersti Nesheim
AU  - Power KN
AD  - Department of Neurology, Haukeland University Hospital, Bergen, Norway; 
      Department of Clinical Medicine, Section for Neurology, University of Bergen, 
      Norway. Electronic address: kjersti.nesheim.power@helse-bergen.no.
FAU - Gramstad, Arne
AU  - Gramstad A
AD  - Department of Neurology, Haukeland University Hospital, Bergen, Norway; 
      Department of Biological and Medical Psychology, University of Bergen, Norway.
FAU - Gilhus, Nils Erik
AU  - Gilhus NE
AD  - Department of Neurology, Haukeland University Hospital, Bergen, Norway; 
      Department of Clinical Medicine, Section for Neurology, University of Bergen, 
      Norway.
FAU - Engelsen, Bernt A
AU  - Engelsen BA
AD  - Department of Neurology, Haukeland University Hospital, Bergen, Norway; 
      Department of Clinical Medicine, Section for Neurology, University of Bergen, 
      Norway.
LA  - eng
PT  - Journal Article
DEP - 20141002
PL  - England
TA  - Seizure
JT  - Seizure
JID - 9306979
RN  - 0 (Anticonvulsants)
SB  - IM
EIN - Seizure. 2015 Dec;33:103
CIN - Seizure. 2015 Dec;33:99. PMID: 26341145
CIN - Seizure. 2015 Dec;33:100. PMID: 26385398
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Anticonvulsants/therapeutic use
MH  - Cohort Studies
MH  - Electroencephalography
MH  - Epilepsy, Generalized/complications/*etiology/*therapy
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Outcome Assessment, Health Care
MH  - Severity of Illness Index
MH  - Status Epilepticus/complications/*etiology/*therapy
MH  - *Treatment Outcome
MH  - Young Adult
OTO - NOTNLM
OT  - Aetiology
OT  - Epilepsy
OT  - Nonconvulsive status epilepticus
OT  - Outcome
OT  - Status epilepticus
EDAT- 2014/12/03 06:00
MHDA- 2015/09/01 06:00
CRDT- 2014/12/03 06:00
PHST- 2014/06/19 00:00 [received]
PHST- 2014/09/08 00:00 [revised]
PHST- 2014/09/24 00:00 [accepted]
PHST- 2014/12/03 06:00 [entrez]
PHST- 2014/12/03 06:00 [pubmed]
PHST- 2015/09/01 06:00 [medline]
AID - S1059-1311(14)00258-1 [pii]
AID - 10.1016/j.seizure.2014.09.007 [doi]
PST - ppublish
SO  - Seizure. 2015 Jan;24:102-6. doi: 10.1016/j.seizure.2014.09.007. Epub 2014 Oct 2.