PMID- 25458120
OWN - NLM
STAT- MEDLINE
DCOM- 20150330
LR  - 20141208
IS  - 1873-2550 (Electronic)
IS  - 0304-4017 (Linking)
VI  - 206
IP  - 1-2
DP  - 2014 Nov 15
TI  - Effects of intravenous and subcutaneous heartworm homogenate from 
      doxycycline-treated and untreated donor dogs on bronchial reactivity and lung in 
      cats.
PG  - 14-23
LID - S0304-4017(14)00506-8 [pii]
LID - 10.1016/j.vetpar.2014.09.021 [doi]
AB  - A controlled, blind research study was conducted to define the innate response of 
      lungs in specific pathogen free (SPF) cats to intravenous (n=10) or subcutaneous 
      (n=4) administration of homogenate of adult Dirofilaria immitis from donor dogs 
      compared with lung response in control cats (n=6). There was no difference in 
      cats that received heartworm homogenate IV for 18 days from donor dogs treated 
      with doxycycline for 1 month compared with cats given heartworm homogenate from 
      untreated donor dogs. Cats did not develop clinical signs, and no radiographic 
      changes were noted. Cats given SC heartworm homogenate at lower concentration 
      than IV groups did not develop histologic changes. Cats that received IV 
      heartworm homogenate for 18 days developed mild interstitial and peribronchial 
      myofibrocyte proliferation and smooth muscle proliferation of the pulmonary 
      arteries. Bronchial ring contractility in vitro was blunted in the IV homogenate 
      cats to the agonists acetylcholine and 5-hydroxytryptamine. Cats in the SC group 
      had increased sensitivity to histamine at high concentrations but normal 
      contractility and relaxation responses to other agonists. No increase in mast 
      cells was noted in lung tissues of cats given homogenate. In the absence of 
      bronchial wall remodeling, cats given IV homogenate had blunted responses to 
      bronchial constriction, but normal relaxation to nitroprusside and substance P 
      and increased sensitivity to histamine. In the absence adult heartworms, the 
      homogenate of adult heartworms in the circulation of SPF cats induced a direct 
      effect on lung parenchyma and altered bronchial ring reactivity.
CI  - Copyright (c) 2014 The Authors. Published by Elsevier B.V. All rights reserved.
FAU - Dillon, A Ray
AU  - Dillon AR
AD  - Department of Clinical Sciences, College of Veterinary Medicine, Auburn 
      University, AL 36830, USA. Electronic address: dilloar@auburn.edu.
FAU - Tillson, D M
AU  - Tillson DM
AD  - Department of Clinical Sciences, College of Veterinary Medicine, Auburn 
      University, AL 36830, USA.
FAU - Wooldridge, A
AU  - Wooldridge A
AD  - Department of Clinical Sciences, College of Veterinary Medicine, Auburn 
      University, AL 36830, USA.
FAU - Cattley, R
AU  - Cattley R
AD  - Department of Clinical Sciences, College of Veterinary Medicine, Auburn 
      University, AL 36830, USA.
FAU - Brawner, B
AU  - Brawner B
AD  - Department of Clinical Sciences, College of Veterinary Medicine, Auburn 
      University, AL 36830, USA.
FAU - Cole, R
AU  - Cole R
AD  - Department of Clinical Sciences, College of Veterinary Medicine, Auburn 
      University, AL 36830, USA.
FAU - Welles, B
AU  - Welles B
AD  - Department of Clinical Sciences, College of Veterinary Medicine, Auburn 
      University, AL 36830, USA.
FAU - Christopherson, P W
AU  - Christopherson PW
AD  - Department of Clinical Sciences, College of Veterinary Medicine, Auburn 
      University, AL 36830, USA.
FAU - Lee-Fowler, T
AU  - Lee-Fowler T
AD  - Department of Clinical Sciences, College of Veterinary Medicine, Auburn 
      University, AL 36830, USA.
FAU - Borderlon, S
AU  - Borderlon S
AD  - Department of Clinical Sciences, College of Veterinary Medicine, Auburn 
      University, AL 36830, USA.
FAU - Barney, S
AU  - Barney S
AD  - Department of Clinical Sciences, College of Veterinary Medicine, Auburn 
      University, AL 36830, USA.
FAU - Wells, S Z
AU  - Wells SZ
AD  - Department of Clinical Sciences, College of Veterinary Medicine, Auburn 
      University, AL 36830, USA.
FAU - Diffie, E B
AU  - Diffie EB
AD  - Department of Clinical Sciences, College of Veterinary Medicine, Auburn 
      University, AL 36830, USA.
FAU - Schachner, E R
AU  - Schachner ER
AD  - College of Veterinary Medicine, Louisiana State University, Baton Rouge, LA, USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141007
PL  - Netherlands
TA  - Vet Parasitol
JT  - Veterinary parasitology
JID - 7602745
RN  - N12000U13O (Doxycycline)
SB  - IM
MH  - Animals
MH  - Cats
MH  - Dirofilaria immitis/*immunology
MH  - Dirofilariasis/drug therapy
MH  - Dogs
MH  - Doxycycline/therapeutic use
MH  - Immunity, Innate/*immunology
MH  - Lung/*immunology
MH  - Pulmonary Artery/*immunology/physiopathology
MH  - Specific Pathogen-Free Organisms
OTO - NOTNLM
OT  - Dirofilaria immitis
OT  - Feline
OT  - HARD
OT  - Heartworm
OT  - Respiratory disease
EDAT- 2014/12/03 06:00
MHDA- 2015/03/31 06:00
CRDT- 2014/12/03 06:00
PHST- 2014/01/18 00:00 [received]
PHST- 2014/09/15 00:00 [revised]
PHST- 2014/09/29 00:00 [accepted]
PHST- 2014/12/03 06:00 [entrez]
PHST- 2014/12/03 06:00 [pubmed]
PHST- 2015/03/31 06:00 [medline]
AID - S0304-4017(14)00506-8 [pii]
AID - 10.1016/j.vetpar.2014.09.021 [doi]
PST - ppublish
SO  - Vet Parasitol. 2014 Nov 15;206(1-2):14-23. doi: 10.1016/j.vetpar.2014.09.021. 
      Epub 2014 Oct 7.