PMID- 25460673
OWN - NLM
STAT- MEDLINE
DCOM- 20150202
LR  - 20220409
IS  - 1096-0953 (Electronic)
IS  - 0013-9351 (Print)
IS  - 0013-9351 (Linking)
VI  - 136
DP  - 2015 Jan
TI  - Regional PM2.5 and asthma morbidity in an agricultural community: a panel study.
PG  - 505-12
LID - S0013-9351(14)00394-6 [pii]
LID - 10.1016/j.envres.2014.10.030 [doi]
AB  - BACKGROUND: Elevated pediatric asthma morbidity has been observed in rural US 
      communities, but the role of the ambient environment in exacerbating rural asthma 
      is poorly understood. OBJECTIVES: To investigate associations between particulate 
      matter less than 2.5 mum in diameter (PM2.5) and pediatric asthma exacerbations in 
      an agricultural community of Washington State. METHODS: School-aged children with 
      asthma (n=58) were followed for up to 25 months with repeated measures of 
      respiratory health. Asthma symptoms and quick-relief medication use were assessed 
      biweekly through phone administered surveys (n=2023 interviews). In addition, 
      subjects used home peak flow meters on a daily basis to measure forced expiratory 
      volume in one second (FEV1) (n=7830 measurements). Regional PM2.5 was measured at 
      a single air monitor located centrally in the study region. To assess 
      relationships between PM2.5 and these outcomes we used linear regression with 
      generalized estimating equations, adjusting for meteorological and temporal 
      confounders. Effect modification by atopy was explored as well. RESULTS: An 
      interquartile increase (IQR) in weekly PM2.5 of 6.7 mug/m(3) was associated with 
      an increase in reported asthma symptoms Specific symptoms including wheezing, 
      limitation of activities, and nighttime waking displayed the strongest 
      associations. FEV1 as a percent of predicted decreased by 0.9% (95%CI: -1.8, 0.0) 
      for an IQR increase in PM2.5 one day prior, and by 1.4% (95%CI: -2.7, -0.2) when 
      restricted to children with atopic asthma. CONCLUSIONS: This study provides 
      evidence that PM2.5 in an agricultural setting contributes to elevated asthma 
      morbidity. Further work on identifying and mitigating sources of PM2.5 in the 
      area is warranted.
CI  - Copyright (c) 2014 Elsevier Inc. All rights reserved.
FAU - Loftus, Christine
AU  - Loftus C
AD  - Department of Epidemiology, School of Public Health, University of Washington, 
      Box 357236, Seattle, WA 98195, United States. Electronic address: cloftus@uw.edu.
FAU - Yost, Michael
AU  - Yost M
AD  - Department of Environmental and Occupational Health Sciences, School of Public 
      Health, University of Washington, Box 357234, Seattle, WA 98195, United States.
FAU - Sampson, Paul
AU  - Sampson P
AD  - Department of Statistics, College of Arts and Sciences, University of Washington, 
      Box 354322, Seattle, WA 98195, United States.
FAU - Arias, Griselda
AU  - Arias G
AD  - Yakima Valley Farm Workers Clinic, Yakima, WA, United States.
FAU - Torres, Elizabeth
AU  - Torres E
AD  - Northwest Education Center, Radio KDNA, 121 Sunnyside Avenue, Granger, WA 98932, 
      United States.
FAU - Vasquez, Victoria Breckwich
AU  - Vasquez VB
AD  - Pacific Northwest Agricultural Safety and Health Center, School of Public Health, 
      University of Washington, Box 357234, Seattle, WA, United States.
FAU - Bhatti, Parveen
AU  - Bhatti P
AD  - Department of Epidemiology, School of Public Health, University of Washington, 
      Box 357236, Seattle, WA 98195, United States.
FAU - Karr, Catherine
AU  - Karr C
AD  - Department of Epidemiology, School of Public Health, University of Washington, 
      Box 357236, Seattle, WA 98195, United States; Department of Environmental and 
      Occupational Health Sciences, School of Public Health, University of Washington, 
      Box 357234, Seattle, WA 98195, United States; Department of Pediatrics, School of 
      Medicine, University of Washington, Box 356320, Seattle, WA 98195, United States.
LA  - eng
GR  - R21 ES017906/ES/NIEHS NIH HHS/United States
GR  - T32 HD052462/HD/NICHD NIH HHS/United States
GR  - 5R21ES17906-2/ES/NIEHS NIH HHS/United States
GR  - HD052462-01/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20141127
PL  - Netherlands
TA  - Environ Res
JT  - Environmental research
JID - 0147621
RN  - 0 (Particulate Matter)
SB  - IM
MH  - *Agriculture
MH  - Asthma/chemically induced/*epidemiology/physiopathology
MH  - Cohort Studies
MH  - Female
MH  - Humans
MH  - Longitudinal Studies
MH  - Male
MH  - Particulate Matter/*toxicity
MH  - Respiratory Function Tests
MH  - Washington/epidemiology
PMC - PMC4425279
MID - NIHMS645729
OTO - NOTNLM
OT  - Agricultural air quality
OT  - Asthma exacerbations
OT  - PM2.5
OT  - Pediatric asthma
OT  - Rural asthma
COIS- Competing financial interests The authors declare that they have no competing 
      financial interests.
EDAT- 2014/12/03 06:00
MHDA- 2015/02/03 06:00
PMCR- 2016/01/01
CRDT- 2014/12/03 06:00
PHST- 2014/05/18 00:00 [received]
PHST- 2014/09/21 00:00 [revised]
PHST- 2014/10/15 00:00 [accepted]
PHST- 2014/12/03 06:00 [entrez]
PHST- 2014/12/03 06:00 [pubmed]
PHST- 2015/02/03 06:00 [medline]
PHST- 2016/01/01 00:00 [pmc-release]
AID - S0013-9351(14)00394-6 [pii]
AID - 10.1016/j.envres.2014.10.030 [doi]
PST - ppublish
SO  - Environ Res. 2015 Jan;136:505-12. doi: 10.1016/j.envres.2014.10.030. Epub 2014 
      Nov 27.