PMID- 25460830
OWN - NLM
STAT- MEDLINE
DCOM- 20150821
LR  - 20191210
IS  - 1531-4332 (Electronic)
IS  - 1095-6433 (Linking)
VI  - 180
DP  - 2015 Feb
TI  - Effect of the liquorice root derivatives on salt and water balance in a teleost 
      fish, rainbow trout (Oncorhynchus mykiss).
PG  - 86-97
LID - S1095-6433(14)00224-4 [pii]
LID - 10.1016/j.cbpa.2014.09.041 [doi]
AB  - The effect of liquorice root derivatives (LRDs) glycyrrhizic acid (GL) and 
      glycyrrhetinic acid (18betaGA) on salt and water balance and end points of gill ion 
      transport in a freshwater teleost, (rainbow trout) was examined after feeding 
      fish diets containing GL or 18betaGA (0, 5, 50 or 500 microg/g diet) for a two week 
      period. Serum cortisol levels and gill 11beta-hydroxysteroid dehydrogenase type 2 
      mRNA abundance decreased in fish fed GL but increased (at select doses) in fish 
      fed 18betaGA. At higher doses of GL, gill Na(+)-K(+)-ATPase and H(+)-ATPase activity 
      increased, while cystic fibrosis transmembrane conductance regulator type II mRNA 
      abundance significantly decreased at the lowest dose of GL. End points of gill 
      transcellular ion transport were not significantly altered in fish fed 18betaGA, 
      except for a reduction in Na(+)-K(+)-ATPase activity at a 50 microg/g dose. In 
      contrast, high doses of GL and 18betaGA increased gill transcript abundance of the 
      tight junction protein claudin-31 (cldn-31). Other end points of gill 
      paracellular transport differed in fishes fed LRDs. Tricellulin mRNA abundance 
      was increased by high dose GL and decreased by high dose 18betaGA, and cldn-23a and 
      cldn-27b mRNA abundance significantly decreased in response to GL irrespective of 
      dose. Despite the above observations, systemic end points of salt and water 
      balance (i.e. serum [Na(+)] and [Cl(-)] as well as muscle moisture) were 
      unaffected by LRDs. Therefore data suggest that LRDs can alter end points of ion 
      transport in fishes but that overall salt and water balance need not be 
      perturbed.
CI  - Copyright (c) 2014 Elsevier Inc. All rights reserved.
FAU - Chen, Chun Chih
AU  - Chen CC
AD  - Department of Biology, York University, Toronto, Ontario, Canada M3J 1P3. 
      Electronic address: kupo@yorku.ca.
FAU - Kolosov, Dennis
AU  - Kolosov D
AD  - Department of Biology, York University, Toronto, Ontario, Canada M3J 1P3.
FAU - Kelly, Scott P
AU  - Kelly SP
AD  - Department of Biology, York University, Toronto, Ontario, Canada M3J 1P3.
LA  - eng
PT  - Journal Article
DEP - 20141112
PL  - United States
TA  - Comp Biochem Physiol A Mol Integr Physiol
JT  - Comparative biochemistry and physiology. Part A, Molecular & integrative 
      physiology
JID - 9806096
RN  - 0 (RNA, Messenger)
RN  - 6FO62043WK (Glycyrrhizic Acid)
RN  - EC 7.2.2.13 (Sodium-Potassium-Exchanging ATPase)
RN  - P540XA09DR (Glycyrrhetinic Acid)
SB  - IM
MH  - Animals
MH  - Gene Expression/drug effects
MH  - Gills/drug effects/metabolism
MH  - Glycyrrhetinic Acid/*administration & dosage/chemistry
MH  - Glycyrrhiza/chemistry
MH  - Glycyrrhizic Acid/*administration & dosage/chemistry
MH  - Ion Transport/drug effects
MH  - Oncorhynchus mykiss
MH  - RNA, Messenger/biosynthesis
MH  - Sodium-Potassium-Exchanging ATPase/biosynthesis
MH  - Water-Electrolyte Balance/*drug effects
OTO - NOTNLM
OT  - 11beta-Hydroxysteroid dehydrogenase type 2
OT  - Cortisol
OT  - Gill
OT  - Glycyrrhetinic acid
OT  - Glycyrrhizic acid
OT  - Ion transport
OT  - Tight junction
EDAT- 2014/12/03 06:00
MHDA- 2015/08/22 06:00
CRDT- 2014/12/03 06:00
PHST- 2014/06/19 00:00 [received]
PHST- 2014/08/27 00:00 [revised]
PHST- 2014/09/03 00:00 [accepted]
PHST- 2014/12/03 06:00 [entrez]
PHST- 2014/12/03 06:00 [pubmed]
PHST- 2015/08/22 06:00 [medline]
AID - S1095-6433(14)00224-4 [pii]
AID - 10.1016/j.cbpa.2014.09.041 [doi]
PST - ppublish
SO  - Comp Biochem Physiol A Mol Integr Physiol. 2015 Feb;180:86-97. doi: 
      10.1016/j.cbpa.2014.09.041. Epub 2014 Nov 12.