PMID- 25461299
OWN - NLM
STAT- MEDLINE
DCOM- 20150417
LR  - 20150214
IS  - 1879-1891 (Electronic)
IS  - 0002-9394 (Linking)
VI  - 159
IP  - 3
DP  - 2015 Mar
TI  - Nonglaucomatous localized retinal nerve fiber layer defects in Behcet uveitis.
PG  - 475-81.e1
LID - S0002-9394(14)00770-3 [pii]
LID - 10.1016/j.ajo.2014.11.029 [doi]
AB  - PURPOSE: To describe nonglaucomatous retinal nerve fiber layer (RNFL) defects in 
      patients with Behcet uveitis. DESIGN: Cross-sectional study and observational 
      case series. METHODS: We reviewed the clinical photographs of patients with 
      Behcet uveitis (n = 259), ocular toxoplasmosis (n = 120), and multiple sclerosis 
      (MS)-associated uveitis (n = 40) for the presence of localized RNFL defects. 
      Behcet patients with localized RNFL defects were invited to participate in a 
      prospective evaluation including standard automated perimetry, spectral-domain 
      optical coherence tomography (SD OCT), and RNFL thickness analysis. Main outcome 
      measures were the prevalence of localized RNFL defects, perimetric and SD OCT 
      findings, and RNFL thickness analysis. RESULTS: Sixty-two patients with Behcet 
      uveitis (24%) had localized RNFL defect(s) without any visible scar. Twenty 
      patients (17%) with ocular toxoplasmosis had a localized RNFL defect associated 
      with a retinochoroidal scar in all. None of the MS patients had a localized RNFL 
      defect. Of the 19 patients (24 eyes) with RNFL defect associated with Behcet 
      uveitis who returned for follow-up, there was a corollary thinning on SD OCT 
      B-scan in all and a corresponding visual field defect in 83%. RNFL thickness 
      analysis was within normal limits in 54%, but revealed thinning in the thickness 
      profile scale in 46% and in the pie chart in 21%. CONCLUSION: In Behcet uveitis, 
      localized RNFL defects may be caused by microvascular ischemia at the optic nerve 
      head and/or at the posterior pole and may serve as a helpful ocular diagnostic 
      clue and an indicator of posterior pole involvement, a risk factor for poor 
      visual prognosis.
CI  - Copyright (c) 2015 Elsevier Inc. All rights reserved.
FAU - Oray, Merih
AU  - Oray M
AD  - Department of Ophthalmology, Istanbul University, Istanbul Faculty of Medicine, 
      Istanbul, Turkey.
FAU - Onal, Sumru
AU  - Onal S
AD  - Department of Ophthalmology, Koc University, School of Medicine, Istanbul, 
      Turkey; Department of Ophthalmology, Vehbi Koc Foundation, American Hospital, 
      Istanbul, Turkey.
FAU - Bayraktar, Serife
AU  - Bayraktar S
AD  - Department of Ophthalmology, Istanbul University, Istanbul Faculty of Medicine, 
      Istanbul, Turkey.
FAU - Izgi, Belgin
AU  - Izgi B
AD  - Department of Ophthalmology, Istanbul University, Istanbul Faculty of Medicine, 
      Istanbul, Turkey.
FAU - Tugal-Tutkun, Ilknur
AU  - Tugal-Tutkun I
AD  - Department of Ophthalmology, Istanbul University, Istanbul Faculty of Medicine, 
      Istanbul, Turkey. Electronic address: tutkun@turk.net.
LA  - eng
PT  - Journal Article
PT  - Observational Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20141126
PL  - United States
TA  - Am J Ophthalmol
JT  - American journal of ophthalmology
JID - 0370500
SB  - IM
MH  - Adult
MH  - Behcet Syndrome/*diagnosis
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Multiple Sclerosis/diagnosis
MH  - Nerve Fibers/*pathology
MH  - Prevalence
MH  - Prospective Studies
MH  - Retinal Ganglion Cells/*pathology
MH  - Tomography, Optical Coherence
MH  - Toxoplasmosis, Ocular/diagnosis
MH  - Uveitis, Anterior/*diagnosis
MH  - Visual Field Tests
MH  - Visual Fields
MH  - Young Adult
EDAT- 2014/12/03 06:00
MHDA- 2015/04/18 06:00
CRDT- 2014/12/03 06:00
PHST- 2014/08/04 00:00 [received]
PHST- 2014/11/16 00:00 [revised]
PHST- 2014/11/19 00:00 [accepted]
PHST- 2014/12/03 06:00 [entrez]
PHST- 2014/12/03 06:00 [pubmed]
PHST- 2015/04/18 06:00 [medline]
AID - S0002-9394(14)00770-3 [pii]
AID - 10.1016/j.ajo.2014.11.029 [doi]
PST - ppublish
SO  - Am J Ophthalmol. 2015 Mar;159(3):475-81.e1. doi: 10.1016/j.ajo.2014.11.029. Epub 
      2014 Nov 26.