PMID- 2546282
OWN - NLM
STAT- MEDLINE
DCOM- 19890825
LR  - 20061115
IS  - 0340-6245 (Print)
IS  - 0340-6245 (Linking)
VI  - 61
IP  - 2
DP  - 1989 Apr 25
TI  - The relative antithrombotic effectiveness of heparin, a low molecular weight 
      heparin, and a pentasaccharide fragment in an animal model.
PG  - 204-7
AB  - The antithrombotic efficacy of unfractionated heparin (UFH), a low molecular 
      weight heparin (LMWH) and a synthetic pentasaccharide (PENTA) has been compared 
      in an animal model for stasis thrombosis. We have also compared the relative 
      ability of these three agents to impair thrombin generation in vitro and in vivo, 
      and measured their effects on anti-Xa activity and thrombin clotting times. UFH, 
      LMWH and PENTA all had the capacity to impair thrombogenesis, although there were 
      marked differences in their relative effectiveness. Reduction of thrombin 
      generation to 20% of control values was closely correlated with the prevention of 
      thrombosis after 20 minutes' stasis, but this was only achieved with UFH. The 
      same dry weight dose of LMWH or PENTA reduced thrombin generation to about half 
      control values, and neither significantly impaired thrombus formation after 20 
      minutes' stasis. Impaired thrombin generation correlated better than anti-Xa 
      activity with prevention of stasis thrombosis. In this model, UFH was clearly 
      superior to LMWH and PENTA as an antithrombotic agent.
FAU - Thomas, D P
AU  - Thomas DP
AD  - Division of Haematology, National Institute for Biological Standards and Control, 
      Potters Bar, Herts., UK.
FAU - Merton, R E
AU  - Merton RE
FAU - Gray, E
AU  - Gray E
FAU - Barrowcliffe, T W
AU  - Barrowcliffe TW
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Germany
TA  - Thromb Haemost
JT  - Thrombosis and haemostasis
JID - 7608063
RN  - 0 (Heparin, Low-Molecular-Weight)
RN  - 0 (Oligosaccharides)
RN  - 9005-49-6 (Heparin)
SB  - IM
MH  - Animals
MH  - Disease Models, Animal
MH  - Heparin/*therapeutic use
MH  - Heparin, Low-Molecular-Weight/*therapeutic use
MH  - Humans
MH  - Oligosaccharides/*therapeutic use
MH  - Rabbits
MH  - Thrombosis/*drug therapy
EDAT- 1989/04/25 00:00
MHDA- 1989/04/25 00:01
CRDT- 1989/04/25 00:00
PHST- 1989/04/25 00:00 [pubmed]
PHST- 1989/04/25 00:01 [medline]
PHST- 1989/04/25 00:00 [entrez]
PST - ppublish
SO  - Thromb Haemost. 1989 Apr 25;61(2):204-7.