PMID- 25463255
OWN - NLM
STAT- MEDLINE
DCOM- 20150619
LR  - 20181202
IS  - 1879-1298 (Electronic)
IS  - 0045-6535 (Linking)
VI  - 118
DP  - 2015 Jan
TI  - Persistent organic pollutants in matched breast milk and infant faeces samples.
PG  - 309-14
AB  - Assessing blood concentration of persistent organic pollutants (POPs) in infants 
      is difficult due to the ethical and practical difficulties in obtaining 
      sufficient quantities of blood. To determine whether measuring POPs in faeces 
      might reflect blood concentration during infancy, we measured the concentrations 
      of a range of POPs (i.e. polychlorinated biphenyls (PCBs), polybrominated 
      diphenyl ethers (PBDEs) and organochlorine pesticides (OCPs)) in a pilot study 
      using matched breast milk and infant faecal samples obtained from ten 
      mother-child pairs. All infants were breast fed, with 8 of them also receiving 
      solid food at the time of faecal sampling. In this small dataset faecal 
      concentrations (range 0.01-41 ng g(-1) lipid) are strongly associated with milk 
      concentrations (range 0.02-230 ng g(-1) lipid). Associations with other factors 
      generally could not be detected in this dataset, with the exception of a small 
      effect of age or growth. Different sources (external or internal) of exposure 
      appeared to directly influence faecal concentrations of different chemicals based 
      on different inter-individual variability in the faeces-to-milk concentration 
      ratio Rfm. Overall, the matrix of faeces as an external measure of internal 
      exposure in infants looks promising for some chemicals and is worth assessing 
      further in larger datasets.
FAU - Chen, Yiqin
AU  - Chen Y
FAU - Wang, Xianyu
AU  - Wang X
FAU - Li, Yan
AU  - Li Y
FAU - Toms, Leisa-Maree L
AU  - Toms LM
FAU - Gallen, Michael
AU  - Gallen M
FAU - Hearn, Laurence
AU  - Hearn L
FAU - Aylward, Lesa L
AU  - Aylward LL
FAU - McLachlan, Michael S
AU  - McLachlan MS
FAU - Sly, Peter D
AU  - Sly PD
FAU - Mueller, Jochen F
AU  - Mueller JF
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Chemosphere
JT  - Chemosphere
JID - 0320657
RN  - 0 (Environmental Pollutants)
RN  - 0 (Halogenated Diphenyl Ethers)
RN  - 0 (Pesticides)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Animals
MH  - Breast Feeding
MH  - Environmental Pollutants/*analysis/blood
MH  - Feces/*chemistry
MH  - Female
MH  - Halogenated Diphenyl Ethers/*analysis/blood
MH  - Humans
MH  - Infant
MH  - Linear Models
MH  - Milk, Human/*chemistry
MH  - Pesticides/*analysis/blood
MH  - Pilot Projects
MH  - Polychlorinated Biphenyls/*analysis/blood
MH  - Tissue Distribution
EDAT- 2014/12/03 06:00
MHDA- 2015/06/20 06:00
CRDT- 2014/12/03 06:00
PHST- 2014/07/05 00:00 [received]
PHST- 2014/09/19 00:00 [revised]
PHST- 2014/09/20 00:00 [accepted]
PHST- 2014/12/03 06:00 [entrez]
PHST- 2014/12/03 06:00 [pubmed]
PHST- 2015/06/20 06:00 [medline]
AID - S0045-6535(14)01152-7 [pii]
AID - 10.1016/j.chemosphere.2014.09.076 [doi]
PST - ppublish
SO  - Chemosphere. 2015 Jan;118:309-14. doi: 10.1016/j.chemosphere.2014.09.076.