PMID- 25464804
OWN - NLM
STAT- MEDLINE
DCOM- 20150518
LR  - 20211203
IS  - 1001-5515 (Print)
IS  - 1001-5515 (Linking)
VI  - 31
IP  - 4
DP  - 2014 Aug
TI  - [Vasculogenic mimicry in laryngeal squamous cell carcinoma and its 
      clinicopathological significance].
PG  - 865-9
AB  - The present paper aims to investigate whether or not vasculogenic mimicry (VM) 
      exists in laryngeal squamous cell carcinoma (LSCC), and to elucidate its 
      relationship to microvessel density (MVD), galectin-3 (Gal-3) expression, and 
      clinicopathological factors of patients with LSCC. VM, score of MVD and 
      expression of Gal-3 protein were detected by immunohistochemistry and 
      histochemistry in 83 specimens of LSCC tissue and 20 specimens of normal 
      laryngeal tissue. The positive rate of VM in normal laryngeal tissues was 0%, and 
      was 33.7% in LSCC tissues. There was a significant difference between the two 
      groups (P<0. 01). VM or MVD was significantly related to differentiation, pTNM 
      stages and lymph node metastasis of LSCC (P<0.05), but not to age, gender and 
      tumor site (P>0. 05). And there was a positive correlation between every two of 
      VM, score of MVD, and Gal-3 protein (P< 0. 05). The results suggest that 
      expression of Gal-3 protein may be related to the initiation, angiogenesis and VM 
      formation in LSCC; And VM, angiogenesis and Gal-3 protein may be involved in the 
      development, invasion and metastasis of LSCC.
FAU - Wu, Shiwu
AU  - Wu S
FAU - Yu, Lan
AU  - Yu L
FAU - Zhou, Lei
AU  - Zhou L
FAU - Cheng, Zenong
AU  - Cheng Z
FAU - Wang, Danna
AU  - Wang D
LA  - chi
PT  - Journal Article
PL  - China
TA  - Sheng Wu Yi Xue Gong Cheng Xue Za Zhi
JT  - Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = 
      Shengwu yixue gongchengxue zazhi
JID - 9426398
RN  - 0 (Blood Proteins)
RN  - 0 (Galectin 3)
RN  - 0 (Galectins)
RN  - 0 (LGALS3 protein, human)
SB  - IM
MH  - Blood Proteins
MH  - Carcinoma, Squamous Cell/*blood supply
MH  - Galectin 3/metabolism
MH  - Galectins
MH  - Head and Neck Neoplasms/*blood supply
MH  - Humans
MH  - Immunohistochemistry
MH  - Laryngeal Neoplasms/*blood supply
MH  - Lymphatic Metastasis
MH  - *Neovascularization, Pathologic
MH  - Prognosis
MH  - Squamous Cell Carcinoma of Head and Neck
EDAT- 2014/12/04 06:00
MHDA- 2015/05/20 06:00
CRDT- 2014/12/04 06:00
PHST- 2014/12/04 06:00 [entrez]
PHST- 2014/12/04 06:00 [pubmed]
PHST- 2015/05/20 06:00 [medline]
PST - ppublish
SO  - Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2014 Aug;31(4):865-9.