PMID- 25465853
OWN - NLM
STAT- MEDLINE
DCOM- 20150602
LR  - 20211203
IS  - 1861-0293 (Electronic)
IS  - 1340-3443 (Linking)
VI  - 69
IP  - 2
DP  - 2015 Apr
TI  - Antidepressant-like effect of essential oil isolated from Toona ciliata Roem. 
      var. yunnanensis.
PG  - 191-7
LID - 10.1007/s11418-014-0878-0 [doi]
AB  - Depressive order is one of the most common psychiatric diseases, and Toona 
      ciliata Roem. var. yunnanensis has shown many bioactivities in folk medicine. 
      This study was designed to investigate the antidepressant-like effect of 
      essential oil isolated from T. ciliata Roem. var. yunnanensis. Gas chromatography 
      and mass spectrometry (GC-MS) was used to analyze the compositions of essential 
      oil. The immobility time in the forced swimming test (FST), tail suspending test 
      (TST), and open field test (OFT) were used to evaluate the antidepressive effects 
      of essential oil. Furthermore, chronic mild stress (CMS) rats were established, 
      and contents of dopamine (DA), norepinephrine (NE), and 5-hydroxytryptamine 
      (5-HT) in the brain were determined by high-performance liquid 
      chromatography-electron capture detector (HPLC-ECD). Western blotting was 
      performed to investigate the effects of essential oil on the expressions of 
      brain-derived neurotrophic factor (BDNF) protein in rats' brain. The GC-MS 
      analysis showed that the main components of essential oil were estragole 
      (6.16 %), beta-elemene (24.91 %), beta-cubebene (14.29 %), and gamma-elemene (8.05 %). The 
      results from the FST and TST demonstrated that the immobility time could be 
      significantly reduced by essential oil (10, 20, 40, and 80 mg/kg), without 
      accompanying changes in ambulation when assessed in the OFT. Additionally, the 
      contents of DA, NE, 5-HT, and BDNF in the hippocampus of CMS rats could be 
      increased by treatment with essential oil at doses of 20, 40, and 80 mg/kg. All 
      these results suggested that essential oil could be considered as a new candidate 
      for curing depressive disorders.
FAU - Duan, Dongmei
AU  - Duan D
AD  - Department of Health Care, General Hospital of People's Liberation Army, Beijing, 
      100853, China, dmduan2014@163.com.
FAU - Chen, Liping
AU  - Chen L
FAU - Yang, Xiuyan
AU  - Yang X
FAU - Tu, Ya
AU  - Tu Y
FAU - Jiao, Shuang
AU  - Jiao S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141203
PL  - Japan
TA  - J Nat Med
JT  - Journal of natural medicines
JID - 101518405
RN  - 0 (Allylbenzene Derivatives)
RN  - 0 (Anisoles)
RN  - 0 (Antidepressive Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Oils, Volatile)
RN  - 0 (Plant Extracts)
RN  - 0 (Sesquiterpenes)
RN  - 0 (beta-elemene)
RN  - 11029-06-4 (elemene)
RN  - 333DO1RDJY (Serotonin)
RN  - 9NIW07V3ET (estragole)
RN  - VTD58H1Z2X (Dopamine)
RN  - X4W3ENH1CV (Norepinephrine)
SB  - IM
MH  - Allylbenzene Derivatives
MH  - Animals
MH  - Anisoles/analysis/pharmacology/therapeutic use
MH  - Antidepressive Agents/analysis/pharmacology/*therapeutic use
MH  - Brain/*drug effects/metabolism
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Depression/*drug therapy/metabolism
MH  - Depressive Disorder/drug therapy/metabolism
MH  - Dopamine/metabolism
MH  - Hindlimb Suspension
MH  - Hippocampus/drug effects/metabolism
MH  - Male
MH  - Meliaceae/*chemistry
MH  - Mice
MH  - Mice, Inbred ICR
MH  - Norepinephrine/metabolism
MH  - Oils, Volatile/chemistry/pharmacology/*therapeutic use
MH  - *Phytotherapy
MH  - Plant Extracts/chemistry/pharmacology/*therapeutic use
MH  - Rats
MH  - Serotonin/metabolism
MH  - Sesquiterpenes/analysis/pharmacology/therapeutic use
MH  - Swimming
EDAT- 2014/12/04 06:00
MHDA- 2015/06/03 06:00
CRDT- 2014/12/04 06:00
PHST- 2014/08/09 00:00 [received]
PHST- 2014/11/11 00:00 [accepted]
PHST- 2014/12/04 06:00 [entrez]
PHST- 2014/12/04 06:00 [pubmed]
PHST- 2015/06/03 06:00 [medline]
AID - 10.1007/s11418-014-0878-0 [doi]
PST - ppublish
SO  - J Nat Med. 2015 Apr;69(2):191-7. doi: 10.1007/s11418-014-0878-0. Epub 2014 Dec 3.